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Tag: "signaling" at biology news

A gene's first 'kiss' sets off that affair known as puberty

..."However, it's unlikely that they act alone. Other signaling systems, some of which have probably yet to be identified in humans, help control GnRH release in primates." Besides learning that GPR54 and KiSS-1 are expressed inside the hypothalamus of primates at the time of puberty, the researchers also found ...

DNA Molecules Used To Assemble Nanoparticles

...s, were admitted into the cells and gave off their signaling light. The self-assembled dendrimer clusters were shown to be well formed and functional. "This is the proof-of-concept experiment," Choi said. But now that the assembly system has been worked out, other forms of dendrimer clusters are in the works....

A new mechanism of regulating RNA degradation

...ed, so their activities could be regulated by cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip of the iceberg" for St...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...ed, so their activities could be regulated by cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip of the iceberg" for St...

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

...ental processesinvolved, namely the network of the signaling process in plantreproduction,?said Ozkan. "A better understanding of the interactionof SCA with pollen tubes could help with successful plant breeding?...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

... human host and translates environmental cues into signaling events, which are processed by the parasite. Another unusual feature of the genome is the presence of an unprecedented number of tRNA (transfer RNA) genes, which constitute nearly 10 percent of the sequence data collected for the project. These gene...

Scientists detect probable genetic cause of some Parkinson's disease cases

...paired and can no longer produce dopamine, a brain signaling chemical(neurotransmitter). Without it, individuals can develop tremor ortrembling in hands, arms, legs, jaw, and face; rigidity or stiffness ofthe limbs and trunk; bradykinesia, or slowness of movement; andpostural instability or impaired balance an...

Bound for destruction: Ubiquitination protects against improper Notch signaling

The Notch pathway is an important molecular signaling mechanism whose existence has beenknown, or at lea...on to itseffects on wing structure in flies, Notch signaling is known to beimportant in a number of neural cell fate determination anddevelopmental processes, an...

Research on Worms Yields Clues on Aging

...puts fromthe outside regulate the level of insulin signaling inside the body,which then in turn regulates longevity in the worms," Kornfeld says.Testing the anticonvulsants on longer-lived mutant worms, theresearchers found the drugs further extended their lives, although notto the same degree they extended th...

Scientists discover the cellular roots of graying hair

.... “So the question is: what in the hair follicleis signaling the stem cells that is absent when aging occurs an... we have a much more refined way of dissectingthat signaling pathway in melanoma. Eventually we hope to tap into thisdeath pathway, thereby using drugs to mimic ...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

.... “So the question is: what in the hair follicleis signaling the stem cells that is absent when aging occurs an... we have a much more refined way of dissectingthat signaling pathway in melanoma. Eventually we hope to tap into thisdeath pathway, thereby using drugs to mimic ...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

.... “So the question is: what in the hair follicleis signaling the stem cells that is absent when aging occurs an... we have a much more refined way of dissectingthat signaling pathway in melanoma. Eventually we hope to tap into thisdeath pathway, thereby using drugs to mimic ...

U-M scientists find genes that control growth of common skin cancer

... sensitive locations,such as the face.The Hedgehog signaling pathway plays a key role in normal development,and... focused on the function of uncontrolled Hhpathway signaling in the growth of BCC.The investigators used genetically engineered mice in which they couldmanipulat...

Researchers trace evolution to relatively simple genetic changes

...already shown that the Eda gene makes a protein, a signaling molecule called ectodermal dysplasin. This molecul... Also, comparing what happens to the ectodysplasin signaling molecule when its gene is mutated in humans, and in fish, shows a major difference. The human protei...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...already shown that the Eda gene makes a protein, a signaling molecule called ectodermal dysplasin. This molecul... Also, comparing what happens to the ectodysplasin signaling molecule when its gene is mutated in humans, and in fish, shows a major difference. The human protei...

Studies reveal methods viruses use to sidestep immune system

...on. The viral protease, NS3/4A, chops up essential signaling proteins involved in carrying RIG-I's message to I... now we can spend our time completely defining the signaling pathway that goes from RIG-I all the way down to IRF-3," Dr. Gale said. "Once we've done that, we ho...

Development of portable infectious disease detector

...ology to record rapid changes in themetabolism and signaling of individual cells. To handle such smallnumbers of cells, they have adapted a method for molding micro-channelsand valves into a material similar to that used in soft contact lenses.This has given them the capability to capture, manipulate, grow and...

Alcohol's effects on gene expression in the central nervous system

...lcohol include genes involved in the intracellular signaling process (which can alter how the neuron functions), neuropeptide signaling (which modulates nerve cell activity), and myelin structure (which is needed for communication betwe...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...t to understand thequantitative behavior of a cell signaling pathway in yeast. The AlphaProject is funded by the National Institutes of Health's National HumanGenome Research Institute, which designated MSI as a Center ofExcellence in Genomic Research. The CEGS program supportsmulti-investigator, interdiscipli...

Beyond lithium for bipolar disorder

...in the treated brain slices. This gene codes for a signaling molecule called PACAP in the brain and is known to...sented here warrant further investigation of PACAP signaling in the brain and of the orphan receptor GPR88 as potential new targets in bipolar disorder." Philip...

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