signal 2 5

Tag: "signal" at biology news

Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses

... in Hamilton, MT, NS5 blocks the body's attempt to signal for immune defenses, preventing the immune system from both stopping the spread of virus and helping the body recover from infection. Interferon is so critical for recovery from these infections that it is being tested in clinical trials to treat in...

Reversal of role for a viral protein associated with the development of lymphoma

... contains a sequence of nucleotides similar to the signal normally found at the beginning of an intron. This signal is juxtaposed with another sequence like that normally found at the end of an intron. Such a unique ...

Bitter or sweet? The same taste bud can tell the difference

...n to a nerve fiber must have some way of sending a signal to that fiber. But researchers weren't sure how th...al charge. They compared the resulting electrical signal given off by NPY to what they had found in the earlier work on CCK. "NPY activated a completely dif...

Tagging pathogens with synthetic DNA 'barcodes'

...ored filters that pass only one color at a time. A signal in which the ratio of intensity of green light is four times that of red light, for example, identifies a "4G1R" probe. The researchers say that up to 1,000 different codes can be created using only three fluorescent dyes. To amplify the signals, th...

A novel method to measure circadian cycles

...h a virus engineered to report with a fluorescent signal when a certain host circadian rhythm gene was expr...hythms; it does not, however, directly measure the signal from the central coordinator of circadian rhythms in the brain, the suprachiasmatic nucleus. In t...

Energy management in cells may hold key to cancer defense

...m dying off too quickly. The study's results could signal new advances for combating cancerous tumor growth, but also type 2 diabetes and obesity. The study, published in the August 12 issue of the Journal of Biological Chemistry (JBC), was headed by Dr. Lee Witters, Eugene W. Leonard 1921 Professor of Me...

Treatments have same target, different responses for lung cancer patients with genetic mutation

...side of the cell, as opposed to the intra-cellular signal blocking of drugs like gefitinib. The researchers treated seven different NSCLC cell lines with cetuximab or gefitinib, and compared the drugs' effects on cell growth and cell death or apoptosis. They found that both drugs similarly inhibited the ...

Discovery suggests why stem cells run through stop signs

...microRNAs is responsible for deactivating the stop signal is the next step of our research," said Ruohola-Baker. "The list of chores that microRNAs do within cells keeps growing in new and surprising ways," added Carthew. "This latest discovery with stem cell division makes us wonder if microRNAs also cont...

UCSD study clarifies insulin's role in blocking release of energy in patients with type II diabetes

...ts with type II diabetes –the normal catecholamine signal that triggers fat breakdown and energy release can be drowned out. This can lead to excessive energy storage in the adipocyte,?said Hupfeld. “This may be one reason why chronic obesity and Type II diabetes are often seen together.?/p> “By correct...

Nanoscale method for investigating living systems

...tial and communicate with other cells. This is how signal transduction is performed in your body, but it is also how chemicals react with your body. When, for example, caffeine enters a cell it stimulates the opening and closing of these ion channels. What we've found is that these quantum dots can form art...

Two designer drugs hit same lung cancer target, but only one is effective

...r ability to shut down a mutant, overactive growth signal in lung cancer cells, reports a team headed by sci... to squelch the overexpressed, or overactive, EGFR signal that spurs growth in several types of cancer. In some forms of the disease, including lung cancer of...

Genomatix, AAAS ink agreement

...s and marketing at Genomatix. "The combination of signal transduction pathways, metabolic pathways, transcription factor knowledge, promoter sequence analysis, different Gene Ontology and MESH filters -- all in one dynamically overlayable package -- makes BiblioSpherePE even more powerful and essential for...

Gene for immune deficiency syndromes found

...al lining, known as APRIL and BAFF, to trigger the signal for B cells to mature. Geha believes that additional cases of immune deficiency result from mutations in the APRIL and BAFF genes, and plans to verify this in further studies. ...

Protein amplification in melanoma is possible drug target

...al lining, known as APRIL and BAFF, to trigger the signal for B cells to mature. Geha believes that additional cases of immune deficiency result from mutations in the APRIL and BAFF genes, and plans to verify this in further studies. ...

Researchers Create DNA-Based Sensors for Nano-Tongues and Nano-Noses

...ick up on that change, turning it into an electric signal that can then be reported." According to Johnson, an array of 100 sensors with different response characteristics and an appropriate pattern recognition program would be able to identify a weak known odor in the face of a strong and variable backgro...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...s,?says Fink. “If we can block transmission of the signal at the first neural synapse, it will never reach the brain and you won't feel pain.?/p> That's where the herpes-based vector comes in. Although scientists can use many kinds of vectors to transfer genes into living cells, HSV has a natural abilit...

Variant prion protein causes infection but no symptoms

... "anchor" into the cell membrane--may be unable to signal cells to start the lethal disease process, according to scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. "This work provides novel in...

Drugs from the deep blue

...cell division," Pessah said. Calcium is also a key signal in both fertilization and programmed cell death, he said. Pharmaceuticals that affect calcium channels range from drugs given to organ transplant patients to suppress the immune system, to treatments for high blood pressure and heart disease. Pessah...

NASA satellite data provides rapid analysis of Amazon deforestation

...on, any sort of weather hiccup from the area could signal serious changes for the rest of the world like droughts and severe storms. Global climate is also affected when Amazon burning practices to clear fields for farming result in large fires that create air pollution and release tiny particles, known as...

Tropical Deforestation affects rainfall in the U.S. and around the globe

...on, any sort of weather hiccup from the area could signal serious changes for the rest of the world like droughts and severe storms. Clearly, land-cover changes in tropical regions carry potentially significant consequences on water resources, wildfire frequency, agriculture and related activities at vario...

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