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Tag: "sickle" at biology news

Jumping gene could provide non-viral alternative for gene therapy

...recting single gene disorders, such as hemophilia, sickle cell disease and muscular dystrophy. ...

UCLA paper examines how one disease may prevent another

...nes. He suggested that those carrying the gene for sickle cell anemia were better able to survive in malaria-infected areas. Leprosy patients have severe immune defects and cutaneous anergy -- an inability to respond to skin testing. They hardly ever get psoriasis, a skin disorder. Starvation was used sinc...

Scientists discover that widely available drug also helps fight kidney disease

...scular dystrophy, hemophilia, Down's syndrome, and sickle cell anemia combined. The disease is characterized by the proliferation of cysts that eventually debilitate the kidney, causing kidney failure in half of all patients by the time they reach age 50. Currently no treatment exists to prevent or slow cy...

Birth defects: 8 million annually worldwide

...s some protection against malaria -- specifically, sickle cell, thalassemia, and glucose-6-phosphate dehydro... births); the hemoglobin disorders thalassemia and sickle cell disease (307,897 births); Down syndrome (217,293 births); and G6PD deficiency (177,032 births)....

Researchers show key protein necessary for normal development of red blood cells

... which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have shown in st...archers to future gene therapies for patients with sickle cell anemia and beta-thalassemia. In the October issue of Blood, the journal of the American Associ...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...herapy and RNA interference to genetically reverse sickle cell disease (SCD) in human cells. This research i... production of the abnormal hemoglobin that causes sickle cell disease, a viral vector was introduced in cell cultures of patients who have the disease. The v...

U-M scientists discover identifying markers for primitive blood-forming stem cells

...dy, which could lead to new medical treatments for sickle cell anemia, leukemia and other types of cancer." As with most discoveries in stem cell science, U-M scientists say their work raises new questions for future research. So far they have identified three SLAM markers on hematopoietic stem cells, but ...

Researchers pioneer new gene therapy technique using natural repair process

...erapy will work in several other diseases, such as sickle cell disease." Sickle cell disease is a disorder ...ith disease. In theory, blood stem cells with the sickle cell mutation could be removed, treated with the enzyme and the correct version of the mutant gene, ...

Sickle cell and protection against malaria

...ion against malaria given by carrying the gene for sickle cell haemoglobin may involve the immune system. St...those areas most afflicted by malaria the gene for sickle cell hemoglobin (HbS) occurs very frequently. The protection against malaria occurs in people who ar...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...?A new understanding of the causes for symptoms of sickle cell disease, a condition affecting one in every 6...the National Academy of Sciences. The symptoms of sickle cell disease have generally been attributed to the physical obstruction of blood vessels by distorte...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

...rapy for a variety of diseases such as leukemia or sickle cell disease. In these cases physicians eliminate ...ymphoblastic leukemia) or red cell diseases (e.g., sickle cell disease). Because blood from the normal, healthy donors contained 1,200 to 155,000 sjTREC copi...

Molecular machine may lead to new drugs to combat human diseases

...e has been used to repair hemoglobin infected with sickle cell anemia. The new structure provides scientists with tools to expand on ways to harness this molecular machine, Golden said. The other researchers on this study were Hajeong Kim, graduate student, and Elaine Chase, research associate, both of the...

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