Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
...n the Journal of Clinical Investigation. The paper shows that the CpG 7909 DNA sequence is safe, and increases the immune system's ability to recognize and destroy cancer cells. The Phase I study was conducted by the Lausanne Branch of the Ludwig Institute for Cancer Research (LICR) at the Lausanne Univers...Great White shark evolution debate involves WSU Lake Campus geology professor
... analyzing fossils of several hundred shark teeth, shows that the Great White shares more similarities with...igns of shark teeth. "Our analysis of their teeth shows that Great White and mako sharks have very similar tooth growth trajectories, while those of the gre...Viral protein influences key cell-signaling pathway
New research shows that a protein produced by a cancer-causing virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the cells to divide, helping the virus spread through the body. The study, led by researchers at Ohio St...Biodiversity hotspots identify conservation priorities
...to Russia and Australia combined. The new analysis shows that an estimated 50 percent of all vascular plants and 42 percent of terrestrial vertebrates exist only in these 34 hotspots. The Madrean Pine-Oak Woodlands, a rugged, mountainous area stretching from Mexico to the Southwestern United States, is on...No relief for Pacific Northwest drought
.... Forest Service and Oregon State University, also shows that the northwestern part of the country will face forest and rangeland fires this year that could be unusually severe and generally the worst of any area in the nation. Wet weather has recently predominated in the Southwest, Central and Atlantic c...50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel
...vity at their borders," Goldstein added. "Our work shows how sumoylation controls one important process at the cell surface and hints that it may influence others." Additional authors include co-first authors Sindhu Rajan and Leigh Plant, as well as Michael Rabin and Margaret Butler, all from the Institut...Stem cells from brain transformed to produce insulin at Stanford
...e more problematic embryonic stem cells. The study shows that his intuition was correct. "When you look at islets cells you realize that they resemble neurons," Kim said. Like neurons, islet cells respond to external signals by changing their electrical properties and releasing packages of proteins. In th...McGill researchers shed light on formation of carcinogen in food
...sue of Journal of Agricultural and Food Chemistry, shows how food-based amino acids and sugars break down when heated to produce furan. It also identifies other food components, such as vitamin C and polyunsaturated fatty acids, which may produce furan as an unwanted by-product of cooking, bottling or cann...Stopping smallpox in its tracks: A new anti-viral approach
...ade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and spread. The authors show that treatment with these erbB-1 inhibitors are effective in lowering morbidity and mortality, and boosting T cell immunity, in infect...HIV-1 spread through six transmission lines in the UK
... recent transmission chain identified by the study shows a faster doubling time in 2003 than the other five. Current surveillance data shows a recent increase in infections amongst homosexual men in the UK , which may partly have come throug...Gray wolves maintain the food chain in winter
...limate change. Crucially, Wilmers and Getz's study shows that a robust food chain - including this still embattled top predator - may be even more important as ecological conditions deteriorate. ### Citation: Wilmers CC, Getz WM (2005) Gray wolves as climate change buffers in Yellowstone. PLoS Biol 3(4):...Navigating an integrated yeast network
...shed in the Open Access journal Journal of Biology shows that such maps can also reveal cryptic interactions and enable accurate predictions about interactions that haven't been observed experimentally. A living cell contains thousands of proteins, genes and macromolecules, enmeshed in complex webs of rel...Researchers uncover sequence of major rice pathogen
... that comprise the genome," Dean says. "This paper shows the work of the last two years in bringing this genome to life." Bringing the genome to life means capturing the biological meaning of the genome, Dean says. To do this, he and his colleagues used two strategies: comparative genomics and functional ...Harmful chemicals may reprogram gene response to estrogen
New research shows that exposure to harmful chemicals and drugs durin...se actually develop the disease. The new research shows that when rats with a genetic predisposition to uterine tumors also receive an early-life exposure t...Brain-mapping technique aids understanding of sleep, wakefulness
... to help keep them active. The new study, however, shows that these acetylcholine-producing neurons, or cholinergic cells, are upstream of the orexin neurons as well ?the two send positive, reinforcing signals back and forth. "By being active, animals fire up their cholinergic cells, which feed back to or...Super predators and mass extinctions
...lowing new species to develop over time. The model shows that, much of time, the system is populated with "medium efficiency" predators whose numbers fluctuate only slightly as the prey population waxes and wanes. Inevitably, their stable community is disrupted when mutations lead to a super predator that ...Small species back-up giant marsupial climate change extinction claim
...remain." Analysis of sediment and ecological data shows that it became increasingly arid during the late Pleistocene, which led to the disappearance of woodland and scrubland and expansion of grassland. To verify their results carbon dating was performed on samples. And further work, due to be published ...Potential Drug Target For Treating Cocaine Abuse Found
...ugh the results are preliminary, this breakthrough shows that it may be possible to develop drugs that bloc...ame stimulating effect on the brain. The new study shows this may not be true. "In fact, the interaction between dopamine trans-porters and the substances th...Used in a new way, RNA interference permanently silences key breast cancer gene
...m using this technique in patients, but this study shows that that it may be possible to use RNAi in more than just experiments that silence genes temporarily," says the study's principal investigator, Ralph Arlinghaus, Ph.D., a professor and chair of the Department of Molecular Pathology. Details of the s......alysis of liver cancer cells removed from patients shows that these cells contain large amounts of the natural receptor for the measles virus, CD46. Overexpression of this receptor thus makes liver cancer cells ideal targets for the measles virus. The results confirmed widespread infectivity, toxicity and ...