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Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily

...peptide 23, or FP-23 for short. Prior studies have shown that FP-23 fuses with, and can even break apart, blood cells and other man-made, cell-like structures called liposomes. FP-23 likely plays several roles in viral fusion, according to the researchers. One role already suspected is that FP-23 attaches...

Genomic Analysis Uncovers New Targets for HIV Vaccine

...r, some of these polymorphisms could ultimately be shown to play a major role when future analyses involving more patients are performed, the researchers said. Patients involved in the study came from Switzerland, Italy, United Kingdom, Australia, Spain, and Denmark. The genetic analysis was performed at ...

Agent slows aging in mice

... first time to my knowledge when an agent has been shown to extend median life span in three laboratories,” says Miller, professor of pathology at the U-M Medical School and associate director of the U-M Geriatrics Center. Miller is also a research scientist at the Ann Arbor VA Medical Center. No signif...

Cells re-energize to come back from the brink of death

...) takes over the process. Previous research has shown that cells that become cancerous lack caspase and other proteins needed to support apoptosis after MOMP releases cytochrome c. But this victory over death is short-lived if CICD is activated. However, some cancerous cells not only dodge death from ap...

Releasing fish for the future

...I scientists Matt Broadhurst and Paul Butcher have shown that mortality rates can be significantly improved through changed practices. Key recommendations from an initial two-year project are that fishers should Cut the line on fish that swallow hooks Remove hooks caught in the fish’s mouth M...

Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes

...rubin and HCV infection. “The present study has shown that a pre-chemotherapy viral load higher than 10(5.65) copies per milliliter is associated with poorer survival in HCC patients with chronic HBV infection, and this association is independent of an individual’s hepatic reserve, tumor and clinical fa...

Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring

...said. According to Yauk, previous studies have shown that Ms6-hm and similar locations of non-coding DNA are sensitive to damage from radiation, mutagenic chemicals and intense industrial air particulate pollution. While the researchers did not specifically study the protein-coding regions of DNA where...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...is an important nerve growth promoter and has been shown in other studies to contribute to survival and regeneration of penile nerves. Neurturin also is a nerve growth factor closely related to GDNF. Control mice received only the virus without the GDNF or neurterin genes inserted. Four weeks after the...

Simulations unravel outer membrane transport mechanism

...s to pass through. Crystallographic studies had shown that TonB binds to one end of the luminal domain. Researchers had hypothesized that TonB somehow draws the luminal domain out of the barrel or changes its conformation to make way for the large molecules. Previous studies had been inconclusive, ho...

Hormone helps mice 'hibernate,' survive starvation

... FGF21, a member of a hormone family that has been shown to lower blood glucose levels in diabetic and obese mice. FGF21, in turn, stimulates the use of stored fats as energy and causes torpor. In properly fed mice, FGF21 is not normally active; however, when the researchers introduced FGF21 into these ...

Bigger horns equal better genes

... and genetic diversity. Past research studies have shown that greater genetic diversity correlates with a greater chance of survival. "The size of the horns reliably advertises the genetic quality of the ibex—and the bigger, the better," said Dr. David Coltman, an evolutionary geneticist at the Univers...

How to lose weight and not go hungry: HU researcher develops drug that mimics feeling of 'fullness'

...ural weight loss. In experiments with mice, it was shown that a single oral administration of BL-3020 led to reduced consumption over a period of 24 hours. Over a 12-day period of daily dosages, the mice weighed 40 percent less than the average for mice of their size and age who were not being given the co...

Pesticides choke pathway for nature to produce nitrogen for crops

...stdoctoral fellow at the University of Oregon, has shown that many pesticides interfere with the ability of legumes to recruit soil bacteria needed to provide a natural fertilizer to crops. Credit: University of Oregon Many farmers applying pesticides to boost crop yields may instead be contributing to gr...

Breakthrough developments in rheumatoid arthritis reported

.... Following the cellular pathway, it has been shown that PTPN22 influences the “trigger point” for act...Indeed, the HLA associations with RA have now been shown by Dr. Gregersen and others to directly regulate the immune response to proteins containing citrulli...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

Skin cancer levels have shown a significant increase in Northern Ireland since the early 1990s and are more likely to affect men, older people and those living in more affluent areas, according to a study just published in the June issue of British Journal of Dermatology. Resear...

Researchers examine carbon capture and storage to combat global warming

... carbon sequestration in coal. But studies have shown that leakage, if it happened at all, would be insignificant, Benson said. The IPCC reported that 99 percent retention of the carbon dioxide that is stored would be ''very likely'' over 100 years and ''likely'' over 1,000 years, she said. ''If you ...

Physicist cracks women's random but always lucky choice of X chromosome

...tion based on thermodynamics. Research has already shown that at the key moment in this process both X chromosomes are brought close together within the cell. The Warwick researcher paper says that what happens next is that material for a "protein plug" then begins to gather around both of the XIST suicide...

Plants recognize their siblings, biologists discover

...in animals, but this is the first time it has been shown in plants” said Susan Dudley, associate professor of biology at McMaster University in Hamilton, Canada. “When plants share their pots, they get competitive and start growing more roots, which allows them to grab water and mineral nutrients before th...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

Researchers at Purdue University have shown that common bacteria can deliver a valuable cargo of "smart nanoparticles" into a cell to precisely position sensors, drugs or DNA for the early diagnosis and treatment of various diseases. The approach represents a potential way to overcome hurdl...

Exploring the dark matter of the genome

... stuck, and get chopped up. Other researchers have shown that small interfering RNAs are made in the heterochromatin, which seek out transposons and inactivate them. That's the kind of knowledge that comes from sequencing heterochromatin." Smith uses the metaphor of dark matter to suggest the significa...

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