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Primitive yeast yields secrets of human cholesterol and drug metabolism

... cholesterol is essential for cell survival. To show that Dap1 directly works with P450s and not through some other biochemical steps, Espenshade’s team tested the ability of human Dap1 protein to bind to four of the 57 known human P450 enzymes, essentially challenging Dap1 to bind to P450s that perfor...

Stanford scientists make major breakthrough in regenerative medicine

...e May 2007 issue of The FASEB Journal, researchers show that a human evolutionary ancestor, the sea squirt, can correct abnormalities over a series of generations, suggesting that a similar regenerative process might be possible in people. "We hope the mechanisms underlying this phenomenon will ultimate...

Protein key to organ growth

... the role of TCTP in the cell. "She was able to show genetically and biochemically that TCTP is directly involved in regulating Rheb function so that it regulates cell size as well as cell numbers. We found that in the case of dysfunction, the eyes and wings get smaller," said Choi. "If you completely ...

Stretching DNA to the limit

...orce spectroscopy measurements on viral DNA, which show the unraveling of the DNA double helix upon exposure to UV irradiation. The researchers essentially pick up individual DNA molecules with the tip of a scanning probe microscope and stretch it while measuring the forces generated. These "stretch—relea...

Natural polyester makes new sutures stronger, safer

...animals have shown promise. "We've been able to show we can produce a valve scaffold that functions better and can grow with the animal," Williams said. "If the valve can grow with the patient, you don't need the repeated surgeries." ...

Walking molecule now carries packages

...anoscale Science and Engineering. "Our experiments show a means to transport molecules reliably. This will become as important to the molecular machinery of the future as trucks and conveyor belts are for factories of today." The last paper Bartels and his team published on this subject generated a grea...

Study of planarians offers insight into germ cell development

...anisms. Unlike fruit flies and nematodes, which show signs of germ cell initiation in the earliest stag...uying Wang and the other team members were able to show that nanos is essential for inductive specification in planarians. Blocking nanos expression by mean...

New protein implicated in autism

...cal Investigation, Teiichi Furuichi and colleagues show that mice lacking CADPS2, which is encoded by a gene in the autism susceptibility region of human chromosome 7, had impaired social interactions (when pairs of CADPS2-deficient mice that had never met were placed together they interacted substantiall...

Mitochondrial genes move to the nucleus -- but it's not for the sex

...at identified the sexual properties of plants that show evidence of mitochondrial-nuclear transfer. In all, the scientists collected data from plant species representing 170 genera. ...

Microfluidic chip helps solve cellular mating puzzle

...e partner. The researchers said their findings show the importance of unraveling the role of multiple, apparently redundant proteins that are often activated by the same message passing through a cell. They also address why cells do not get confused when they are activated by multiple signaling messen...

Bacteria from patient's dental plaque causes ventilator-associated pneumonia

...eed is a new infection. Unfortunately, statistics show that as many as 25 percent of all patients admitte...he University at Buffalo School of Dental Medicine show that the same bacteria identified in dental plaque of patients when they were admitted to the ICU an...

Anti-herpes treatment reduces HIV levels in women infected with both viruses

...results of the trial are striking', he adds. 'They show that valacyclovir significantly reduces the frequency and quantity of HIV detectable in genital secretions and, in addition, reduces the quantity of HIV in the plasma. As expected, there was also dramatic reduction in the detection of symptomatic and...

Salamanders suffer delayed effects of common herbicide

... while impacts of the herbicide, atrazine, may not show up in short-term studies, even extremely low concentrations of the chemical may be deadly to amphibians in the long run. "We are concerned that most studies used to make pesticide registration decisions and to derive safe concentrations last for a...

Microfossils unravel climate history of tropical Africa

...al and microfossils from marine algae. The results show that the land environment of tropical Africa was cooled more than the adjacent Atlantic Ocean during the last ice-age. This large temperature difference between land and ocean surface resulted in drier conditions compared to the current situation, wh...

MicroRNA helps prevent tumors

...t hundreds of genes, researchers have struggled to show the biological impact of a particular microRNA on ...s ability to regulate it. In addition, the results show that the interaction of one microRNA with one of its target genes can produce a certain trait in mam...

Scripps Research study reveals new activation mechanism for pain sensing channel

...ravatt and Peter Schultz labs at Scripps Research, show that modification of reactive cysteines within TRPA1 can cause channel activation," Macpherson said. "Our research efforts are now aimed at further understanding how binding of these compounds activate the channel, and identifying the physiological r...

Viral protein is an effective preventative against infection

...’s Vincent A. Fischetti and colleagues at St. Jude show that middle ear infections in mice can be prevented by giving the mice a lysin ?a protein derived from a virus that infects bacteria. The new technology may prevent children with the flu from developing secondary ear infections and would be an attrac...

Birds found to plan for the future

... have a concept of the present, but these findings show that jays also have some understanding of future events and can plan for future eventualities. The western scrub-jays demonstrate behaviour that shows they are concerned both about guarding against food shortages and maximising the variety of their d...

New hereditary breast cancer gene discovered

...tations in a gene called TWIST1. "Our findings show that women with this syndrome run a nearly twenty ... says Göran Stenman. The findings of the study show that women with this syndrome should be receive early mammograms in order to discover breast cancer ...

Organic is healthier: Kiwis prove that green is good

... Medical School, London, believes that the results show a significant reduction in the increase in plasma lipids caused by cholesterol feeding. "This is potentially beneficial to health with regards to heart disease", he added. Casey Gauthier reports on this story in Chemistry & Industry. ### ...

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