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Tag: "severity" at biology news

Antioxidant protects against lung damage in silicosis

...lso represent a novel biomarker for evaluating the severity of silicosis. In their mouse studies, hemin, a potent inducer of HO-1, suppressed acute inflammation after silica exposure, whereas zinc protoporphyrin, an inhibitor of HO-1, accelerated the development of silicosis lesions. ...

New engineered drug may offer prolonged arthritis relief

...IL-1 activity, might have value in diminishing the severity of osteoarthritis, said Mohammed Shamji, a neurosurgery resident pursuing his Ph.D. in Setton's laboratory. However, trials of IL1RA for osteoarthritis have had limited success, primarily because the drug tends to break down quickly, according to t...

Novel vaccine shows promise against early-stage breast cancer

...2/neu, all of which have been known to predict the severity of disease, recurrence and overall survival. Deve...e investigators also noted an improvement in their severity of their disease. "The results demonstrate for the first time that this DC vaccination may have s...

Power emerges from consensus in monkey social networks

...s powerful will be able to terminate or reduce the severity of these conflicts. Power structure is critical to conflict management, which is in turn critical to social cohesion." ...

MRSA toxin acquitted: Study clears suspected key to severe bacterial illness

... that contain PVL and the increased occurrence and severity of CA-MRSA disease, though no one had directly tested the role of PVL in CA-MRSA virulence. In striving to learn more about CA-MRSA, the RML scientists, with their colleagues at the International Center for Public Health (ICPH) in Newark, NJ, and the...

End-of-life care can be improved

...ortant setting for end-of-life care because of the severity of illness in these patients and because many families and patients with chronic, life-limiting diseases will opt for a trial of intensive care. Critical care researchers are taking the lessons learned from previous observational studies and using...

Osteoarthritis may be sign of faster 'biological ageing'

... length was also significantly associated with the severity of osteoarthritis. The more severe the disease, the shorter was the telomere length. The authors suggest that both the ageing process and osteoarthritis share biological factors in common, including oxidative stress and low level chronic inflammati...

A first glimpse of the influenza replication machine

..., thereby reducing the spread of the virus and the severity of the infection. "For many years scientists have tried to understand the flu polymerase and to look for weak points that could be targeted by drugs," says Darren Hart, whose team participated in the research at EMBL Grenoble. "But no one could g...

Hay fever can send work productivity down the drain

...lergic rhinitis. Participants were asked about the severity and type of allergy symptoms they had, and whether... the care of a family physician reported a greater severity of symptoms than did patients treated by an allergist as well as those who self-managed their allerg...

Moonlighting enzyme linked to neurodegenerative disease

...y for Friedreich's ataxia," says Dr. Isaya. The severity of Friedreich's ataxia is proportional to the decrease in the levels of frataxin: the lower the frataxin, the more severe the disease. "Yet, this correlation does not completely explain the clinical variability because even within the same family we ...

How to manage forests in hurricane impact zones

...to reduce the risk of a hurricane occurring or the severity of a hurricane when it hits," says Stanturf. "The long-term focus of managers should be on reducing the vulnerability of coastal ecosystems, particularly in those areas with higher event risk." The researchers developed an approach that considers ...

Health Canada approves cold and flu medicine

...ates that the product “helps reduce the frequency, severity and duration of cold and flu symptoms by boosting the immune system.? Comprehensive therapeutic claims require support by the highest level of scientific evidence: randomized, double-blind, placebo-controlled clinical trials. “This is our stronges...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

...ic cancer, which is very severe. The method grades severity on a 1 to 4 scale, with 4 being the worst case. The "T" designates cancer size; the "N" designates the presence of lymph nodes, which are associated with tumors; and the "M" designates metastasis of the cancer to other organs. The autopsy and other a...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

...acterial component to CF now helps explain why the severity of CF symptoms did not match the pathological effect of the CF mutation alone. The study was published this month in the Proceedings of the National Academy of Sciences. The research, conducted by Zhe Lu, MD, PhD; Yajamana Ramu, PhD; and Yanping X...

White blood cells in lung produce histamine seen in allergies

...tamines, the level of histamine, and therefore the severity of the pneumonia, dropped in proportion to the amount of antihistamine given. "This is a study in mice, so we cannot freely extrapolate the results to human beings," cautions Caughey. "Nonetheless, antihistamines may deserve more of a look as thera...

Researchers urge monitoring of bone health during chemotherapy

...ncrease in tumor burden, a measure of the size and severity of tumors, compared to those that did not receive G-CSF. Interestingly, mice treated with a bisphosphonate, an anti-osteoporosis agent that inhibits osteoclasts, were resistant to the effects of G-CSF on bone tumor growth. Weilbaecher is currently i...

Study to explore using magnets to correct 'sunken chest'

...the brace for three to 12 months, depending on the severity of the deformity. It can be adjusted to increase or decrease the pull on the breastbone in the same way that orthodontic braces are loosened or tightened. If successful, the 3MP could revolutionize treatment of pectus excavatum, according to Harri...

UW launches study testing adult stem cells for heart damage repair

... chest pain related to their heart disease and the severity of the pain. Next, all subjects receive a series of needle shots, typically delivered under the skin in the arm, thigh or abdomen of a commercially produced protein (granulocyte colony stimulating factor). The protein helps to release blood-forming ...

'Night owls' report more insomnia-related symptoms

...ties and waking distress, even after adjusting for severity of sleep disturbance. “Our findings indicate th...ircadian rhythms and insomnia, especially with the severity of the ‘night owl?group,?said Ong. “These factors may serve to perpetuate the insomnia disorder, an...

Chemo combination improves survival in asbestos-related cancer

...nd diarrhea, which decreased in both incidence and severity after the vitamins were added to the treatment. People who work trades such as shipbuilding, railway engineering, construction work and asbestos manufacture have higher rates of mesothelioma than the general public. The cancer may take 10 to 60 years...

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