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Tag: "severity" at biology news

Free-radical busting antioxidants might not promote healthy hearts

...s of oxidized cholesterol in blood vessels and the severity of heart disease. This might help explain the disappointing results of clinical trials with other free radical-scavenging antioxidants, such as Vitamin E, which have shown no protective effect against heart disease in humans. The protective effect o...

Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

...hat in later-myelinating regions of the brain, the severity and rate of myelin breakdown in healthy older individuals is associated with ApoE status. Thus both age, the most important risk factor for Alzheimer disease, and ApoE status, the second-most important risk factor, seem to act through the process of ...

Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging

...f Aβ peptide are toxic and causally related to the severity of AD. The Aβ-peptide is one of the most promising targets for the development of AD therapies. "This scientific paper highlights the potential benefits of Alzhemed?" said Dr. Andreas Orfanos, Neurochem's Executive Vice President, Strategic Plannin...

New MRI technique shows emphysema in asymptomatic smokers

..., we have shown that it is possible to measure the severity of emphysema and its progression through time with... airspace size, the ADC map shows the location and severity of the disease. "The ADC maps are very sensitive to changes in the lung structure," Dr. Fain said. ...

UGA study explains peaks and troughs of dengue epidemics

...onventional wisdom is that an amplification of the severity of disease caused by repeat infections with different strains, a phenomenon known as antibody-dependent enhancement, drives the boom and bust cycles of dengue epidemics. "Temporary cross-immunity has been ignored by the epidemiological community," ...

How can identical twins be genetically different?

...s packaged. "There's a lot of variability in the severity of the disease, symptoms, and the response a patient will have to treatment. Differences in the expression of genes caused by environmental factors that modify DNA have a lot to do with this variability," says Holoshitz. The most significantly over...

Virus has 'catastrophic' affect on red squirrels, research shows

...ase surveillance programme clearly demonstrate the severity and debilitating nature of the squirrel poxvirus disease on red squirrels. "Given that the grey squirrel is an introduced species, and therefore the disease has occurred as a consequence of human action, the onus is very much on us to look for pr...

Case Western Reserve University researchers find protein associated with brain cell death

... process, it holds the potential to "push back the severity of the disease" by developing new drugs that specifically target the component causing the most destruction and decreasing the possibility of injuring or interrupting other biological processes. ...

Neural stem cell gene plays crucial role in eye development

...egree to which SOX2 gene is disrupted dictates the severity of this condition. "We found that even a reduction in normal SOX2 levels causes problems in these mice and this mimics the problems seen in humans," said Pevny. The scientist pointed out that the problem in eye development in these mice results fr...

New bird flu drug promises to beat the problem of resistance

...rom spreading to new cells and helps to reduce the severity and duration of flu so that the body's own defence mechanisms, together with other medical interventions, can help aid recovery. However, the influenza virus can develop resistance to the drugs by mutating, or changing, parts of its surface that Ta...

How bad is malaria anemia? It may depend on your genes

...s in the MIF promoter also have been linked to the severity of other inflammatory diseases. The researchers continue to collaborate in an effort to develop drugs that might block MIF and treat severe anemia in malaria patients. ...

'Smart' genetic therapy helps the body to heal itself

...otein; insufficient to prevent the diseases. The severity of the SMA is influenced by the number of SMN2 genes, which normally vary between one and four ?the more copies there are the better the patient does. Professor Wirth's team identified a drug ?valproate, used successfully in epilepsy treatment for d...

Melatonin improves mood in winter depression

...gnment but in the phase-advance direction. Symptom severity in SAD patients correlated with the misalignment in either direction. The treatment of choice for most SAD patients is bright light exposure, which causes phase advances when scheduled in the morning. Because patients know when they are exposed to b...

High dopamine transporter levels not correlated with ADHD

...ne transporter levels alone cannot account for the severity of symptoms of inattention in ADHD," said Nora Vol... transporters would be required to account for the severity of the symptoms of inattention in ADHD," Volkow said. "We speculate that this other variable may be ...

Resistant bacteria increasing source of muscle infection

...ion between bacteria carrying the pvl gene and the severity of disease," she said. However, she said, they have not yet determined whether the problem is this specific gene or another that is close to it. Others who participated in this research include: Drs. Kristina G. Hulten, Blanca E. Gonzalez, Edward ...

Incidence of stroke decreases over last 50 years

... over the past 50 years has declined, although the severity of stroke has not, according to a study in the Dec...estimates of long-term trends in the incidence and severity of stroke have varied. Determining trends could help guide health programs, public policy, and the a...

New biologic treatment for tennis elbow may replace surgery for chronic sufferers

...log scale (a continuum on which a person rates the severity of his/her pain: 0 = no pain; 100 = maximum pain). They all had completed a course of physical therapy and had tried some combination of anti-inflammatory medicines, bracing or cortisone shots, all without relief of symptoms. Twenty of the origina...

A new understanding of how cells defend themselves against bacterial pore-forming toxins

...n protein toxins that increase the infectivity and severity of bacterial diseases. Once the toxin perforates the host membrane, ions begin to leak out of the cell. Sensing a drop in its potassium concentration, the cell reacts by forming a multi-protein complex known as an inflammasome. Scientists know tha...

Gene chip technology shows potential for identifying life-threatening blood infection

...groups of mice: each of three groups had a varying severity of sepsis and a fourth had systemic non-infectious inflammation. Using gene chips, they created molecular profiles based on the abundance of messenger RNA expressed in immune cells taken from the blood of the sick mice. These profiles were compared w...

Pilot study successful in taming allergic reactions to food

...ncrease in tolerance to eggs and a decrease in the severity of their allergic reactions, Burks said. At the en...pproach can build their tolerance and decrease the severity of their reactions. Peanut allergy, which can be life-threatening, affects approximately 1 percent o...

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