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Tag: "setting" at biology news

In mice, drug protects against diabetes and atherosclerosis

...d chaperone protein aP2 acts as a signal in cells, setting off a chain of inflammatory and metabolic responses to consumption of fatty foods. Some of those effects make the body less sensitive to the sugar-lowering action of insulin, raising the risk of diabetes. For many decades, aP2 was believed to act onl...

U-M researchers discover gene switched off in cancer can be turned on

...a single drug or drug combination to 500 people is setting ourselves up for failure, much like a one-size-fits-all clothing store would never succeed,” Reisman says. “Targeted therapies are now opening the door, because they are essentially given only to those patients who have a high likelihood of respo...

Researchers develop buckyballs to fight allergy

...uckyball – the ability to block allergic response, setting the stage for the development of new therapies for allergy. Allergic disease is the sixth leading cause of chronic disease in the United States, and while various treatments have been developed to control allergy, no cure has been found. These findi...

How brain pacemakers erase diseased messages

... "In the case of tremor, physicians can alter the setting until they see the symptoms stop," Grill said. "You don't have to know how it's really working. "In a condition like epilepsy, however, it's extremely unlikely that a person would have a seizure in the doctor's office," he said. "Therefore, it mig...

Detecting cold, feeling pain: Study reveals why menthol feels fresh

...in insight into how these thresholds change in the setting of injury, such as inflammatory and nerve injury, and how these changes may contribute to chronic pain," says senior author David Julius, PhD, chairman and professor of physiology at UCSF. The methanol receptor, and other temperature receptors di...

Novel system developed to turn data into real-time, interactive 3-D images

...we have developed can move rapidly into a clinical setting and significantly improve the ability of physicians to make diagnoses from a variety of imaging techniques," Blank says. "Our approach allows the physician to rapidly and efficiently study hundreds of images at once by turning the data into a three-d...

Slowing the racing heart

...cell in the upper right chamber is responsible for setting the pace of the beating heart, triggering its neighbor cells to beat. In the human heart, one cell -- the pacemaker cell -- beats faster or slower to induce a rhythmic heartbeat that varies to increase or decrease the blood flow to the body as we eat...

Parasites' impact goes beyond host to affect ecosystem

... by UNH and Cornell University, provided the ideal setting for such an experiment. While C. lingua infects approximately 10 percent of L. littorea living on the mainland, approximately half the snails on Appledore Island are infected. That’s because L. littorea is just one of three hosts in the life cycle of...

Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants

...gning test proteins for maximal GFP detection, and setting up microscope equipment for imaging in plants. This information will be useful to a broad range of scientists interested in plant biology and imaging technologies. A second freely accessible article ( http://www.cshprotocols.org/cgi/content/full...

Paper challenges 1491 Amazonian population theories

...bers across Amazonia and created the modern forest setting that many conservationists take to be ‘natural.' This view has become fashionable among many archaeologists and anthropologists, and is challenged in a recent paper from Dr. Mark Bush of the Florida Institute of Technology. The findings of Bush’s re...

How fish species suffer as a result of warmer waters

...ion ?through respiration and blood circulation ?in setting the animals' thermal tolerance range, in that these processes are optimised to only a limited temperature window. With increasing temperature, the organism's oxygen supply is the first to deteriorate, followed by other biochemical stress responses. F...

Keeping the body in sync -- The stability of cellular clocks

...ypothalamus, and then these clock genes respond by setting up concentration gradients that change in a periodic manner. The cell “interprets?these gradients and unleashes tissue-specific circadian responses. Some examples of output from these clocks are the daily rhythmic changes in body temperature, blood p...

Massey researchers induce cell death in leukemia

...HDAC inhibitors and Bortezomib combinations in the setting of CLL," said Grant. "The findings of our study -- as well as the emerging body of preclinical and early clinical data suggesting interactions between HDAC inhibitors and bortezomib in other tumor cell types, particularly hematologic malignancies -- ...

Carnegie Mellon University research shows how sensory-deprived brain compensates

...rst to show this degree of brain adaptability in a setting with significantly limited sensory input," said Alison Barth, assistant professor of biological sciences and a member of the Center for the Neural Basis of Cognition (CNBC). "This finding tells us that brain function is plastic, or reparable, when a ...

MIT device draws cells close -- but not too close -- together

...human hand. Hui selected 80 micrometers as the gap setting because at shorter distances, cells sometimes migrate across the gap and end up touching. And at wider distances, some soluble signals drop off. Bhatia and Hui have used the new device to study liver cells. The two found that to get liver cells to...

End-of-life care can be improved

...ve care. The ICU is likely to remain an important setting for end-of-life care because of the severity of il... improving the quality of end-of-life care in this setting is seen as an important endeavor. In an article on measuring quality improvement, Dr. Curtis and co...

SARS: No evidence that any of the treatments worked

...tion, studied 117 patients and showed that in this setting the average cost to the health system was US$3,355, and US$837 to the patients. The authors calculated that the mean cost per disability-adjusted life year (DALY) gained by the DOTS-Plus project was US$242 (range US$85 to US$426). In a related perspe...

Electric jolt triggers release of biomolecules, nanoparticles

...n the sulfur atoms and the gold platform to break, setting free the tethered molecule. In theory, the researchers said, this technique could be incorporated into a biocompatible implant chip that would release medicine inside a patient on command. Scientists elsewhere are working on other new drug delive...

Researchers discover mechanism that determines when detailed memories are retained

...g the system involving acetylcholine in the brain, setting the stage for the latest findings. ...

Nanotech tools yield DNA transcription breakthrough

... molecular machine that carries out transcription, setting the stage for new opportunities in combating the bacterial diseases that kill 13 million persons each year worldwide. "For six decades, antibiotics have been our bulwark against bacterial infectious diseases, but this bulwark now is collapsing,"...

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