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Tag: "sequences" at biology news

DNA Molecules Used To Assemble Nanoparticles

...A, typically 34-66 bases long, found complementary sequences on other dendrimers and knitted together, forming barbell shaped two-dendrimer complexes with folate on one end and fluorescence on the other end. Folate receptors are over-expressed on the surface of cancer cells, so these dendrimer clusters would ...

Viral DNA sequence a possible trigger for breast cancer

...e activation and proliferation of the cells. These sequences have also been found in proteins from some other c... this study is the previously reported presence of sequences highly homologous to MMTV Env protein in the DNA of as many as 40% of human breast tumors, although ...

Man and mouse share genome structures

...chromosomal regions, even where the underlying DNA sequences are different. Bernstein and Schreiber began to d...rray technology to identify the underlying genetic sequences associated with the tagged chromatin. Next, they teamed up with Michael Kamal, the co-first author o...

Novel technology detects human DNA mutations

...target DNA SNP segment between two oligonucleotide sequences to greatly increase detection specificity and sensitivity. One segment identifies any mutations in the DNA and the probe, a highly sensitive gold nanoparticle, creates a strong signal accurately indicating the presence of a specific target SNP. Proof...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...terest in what secrets may lie undiscovered in the sequences of other supposedly 'simple' amoeba genomes." Named for its effectiveness in killing other cells, E. histolytica was long considered to be a 'primitive' organism ?originating from the time that bacterial lineages diverged from eukaryotic lineages ?b...

UW's Rosetta software to unlock secrets of many human proteins

...atments.Rosetta works by virtually folding protein sequences into thousands ofpossible shapes, based on certain protein folding "rules" known byscientists. These rules are summarized in the program and are termedthe "Rosetta score." The program tries a great many conformations andreturns those with the lowest ...

Researchers find how protein allows insects to detect and respond to pheromones

...atments.Rosetta works by virtually folding protein sequences into thousands ofpossible shapes, based on certain protein folding "rules" known byscientists. These rules are summarized in the program and are termedthe "Rosetta score." The program tries a great many conformations andreturns those with the lowest ...

New Technique for Tracking Gene Regulators

...ion around the specific locations for CREB binding sequences orgenes that might be regulated by CREB.Using this technique, the scientists have identified some 6,302genome-binding sites for CREB, including many that are located nearknown genes. Genes identified as being regulated by CREB using thismethod includ...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...cer cell to continuously divide. Telomeresare DNA sequences found at the ends of chromosomes that play a key rolein controlling the life span of cells. With every cell division,telomeres get a bit shorter until eventually they become so short thatthe enzymes that copy DNA for cell division no longer work prop...

GATA: a graphic alignment tool for comparative sequence analysis

...cer cell to continuously divide. Telomeresare DNA sequences found at the ends of chromosomes that play a key rolein controlling the life span of cells. With every cell division,telomeres get a bit shorter until eventually they become so short thatthe enzymes that copy DNA for cell division no longer work prop...

Whole genome fine map of rice completed

...s of O. sativa." The fine maps of the rice genome sequences will lay a solid foundation for studying the differences among strains of rice and shed insight into mechanisms of hybrid advantages at a new level, according to BIG researchers. The efficiency and data quality of the fine maps of two strains of ric...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...nce of the open reading frame is compared with the sequences of genes for other proteins (most of which are from different species) in sequence databases. If a close match is found, it is assumed that the function is the same or similar." Rv1347c is one of these annotated antibiotic resistance genes in M. tub...

Scientists seek answers on what activates deadly anthrax spores

...ith a non-pathogenic strain of anthrax. The genome sequences of four strains of the bacteria, known scientifically as Bacillus anthracis, have been determined. The group also will be exploring the three-dimensional structures and the functions of the proteins involved. State-of-the-art facilities at the Cente...

Found: Missing sequence of the human Y chromosome

...accomplishment, substantial sections ofchromosomal sequences were still missing.The Y chromosome, a sex chromos... this sequenceexhibited between 95-99% homology to sequences on exactly half (11 of22) of the other chromosomes in the human genome, including thepericentromeric...

Molecular machine may lead to new drugs to combat human diseases

...her. Scientists are just learning whether many DNA sequences previously believed to have no function actually may play specialized roles in cell behavior. While humans have introns, they don't have Group I introns. Many pathogens that cause human diseases, however, do have Group I introns, including the HIV o...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...as expression. DNA of plants and animals contains sequences encoding microRNAs, important regulators of development, that control processes determining cell type and cell death. "The let-7 microRNA regulates Ras by binding to the message for Ras and likely inhibits translation of the Ras protein," said Slack...

Solution to Pollution: New Bacteria Eats Toxic Waste

...te in the annotation process by which genes in the sequences will be identified. The researchers will be able to understand the genetic material that allows these bacteria to degrade the PAHs and survive in the soil. Such knowledge may help researchers better understand and utilize the organisms to destroy PAH...

Enzyme shown to help protect genomic stability

...tyl, methyl, and ubiquitin molecules in prescribed sequences and patterns. One job of Ubp10, as identified in this study, is to remove ubiquitin from certain histones where ubiquitin is associated with gene activation and to maintain low levels of the ubiquitin molecule at those sites. Interestingly, Ubp10 ap...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...large regions of the genome and identified the DNA sequences associated with chromatin that contains "on" tags. DNA is the same in all the cells in our body. What makes the cells do different jobs is that different genes are turned on. For example, the set of genes turned on in a nerve cell is different from t...

New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

...of the genome are transcribed into overlapping RNA sequences and those sequences are separated by regions in which RNA is transcribed more scarcely. All of the data is freely ava...

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