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Tag: "sequence" at biology news

Tiny clue reveals new path toward heart disease

... section of chromosome 3 for SNPs that differed in sequence between individuals with and without coronary heart disease. One SNP, in the kalirin gene, varied between individuals with heart disease and those without. The researchers repeated the same experiment in four additional patient populations, scann...

Stanford scientists make major breakthrough in regenerative medicine

...t to normal, but are unsuccessful. If the genetic sequence described in the sea squirt applies to humans, this study represents a major step for regenerative medicine. The sea squirt is more closely related to humans than many would expect. It may appear similar to a sea sponge, worm, or plant, but it is...

2,000 influenza virus genomes now completed and publicly accessible

...mples around the world have been completed and the sequence data made available in a public database. "This ...tics." "Scientists around the world can use the sequence data to compare different strains of the virus, identify the genetic factors that determine their vi...

Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting

...undred researchers tapping the massive flow of DNA sequence information will gather March 28-30 to share their recent developments at the 2nd Annual U.S. Department of Energy Joint Genome Institute (DOE JGI) User Meeting. DOE JGI is the world's only user facility dedicated to making high-throughput DNA sequen...

Killing the messenger RNA -- But which one?

...gical consequences. A single substitution in their sequence can redirect these microRNAs to target and silence entirely different sets of genes from their unedited counterparts. Further, errors in the editing can lead to serious health problems. The team’s findings appear in the February 23 issue of Science. ...

Common mechanisms for viral DNA replication

...s protein, papilloma virus E1, share no detectable sequence homology in this region, the two domains bind the DNA in similar ways. In both cases, DNA binding is thought to initiate assembly of a complex of the full-length proteins on DNA. Interestingly, SV40 T-ag DNA-binding domains do not interact with one a...

How fish conquered the ocean

...lutionary terms with their impressive, comparative sequence alignment study of the involved yolk genes and proteins as published in PLoS ONE". In the paper the authors (RN Finn & BA Kristoffersen) have used Bayesian analysis to examine the evolution of vertebrate yolk protein (vitellogenin) genes in r...

Volcanic eruptions, ancient global warming linked

...eroe Islands, where they cooled, leaving a layered sequence of lava flows as deep as six kilometers in some places. Duncan said the eruptions are similar in scale with the well-known Deccan Flood Basalts in India. "They are also about 40 times as big as the Columbia River basalts in Oregon and Washington,"...

'Hidden-hero' microbes in soil, water may help naturally clean toxic sites

...ow has been sequenced, and we will use that genome sequence and those of other 'bugs' at Oak Ridge in developing our new bioremediation strategies for DOE sites." ...

Scientists reveal structure of gateways to gene control

...ecture of gene packaging. "There is a certain DNA sequence that shapes the gene's architecture in the same wa... structure in every gene," Pugh said. The overall sequence of DNA building blocks is different in each gene, but the underlying architecture is the same." T...

Scientists identify a candidate gene for osteoporosis

... colleagues predict that changes in the amino acid sequence or alterations in regulatory regions of the DARC gene may lead to key functional changes. "There are interesting differences between African Americans and Caucasians that could be associated with this gene," explains Mohan. "African Americans e...

Novel laboratory technique nudges genes into activity

...of RNA that were tailor-made to complement the DNA sequence of a specific gene in isolated breast cancer cells. Once the RNA was introduced into the protein mix, the gene was activated, ultimately resulting in a reduced rate of growth in the cancer cells. Dr. Corey said that while it’s clear the activatin...

'The eyes have it' -- Autism research yields surprising results

...pression, or animated and expressive. By showing a sequence of different combinations, they were able to gauge which aspects of the face were used by the autistic children to ‘read?someone’s mental state ?and how successful they were. In the second experiment, the 18 autistic children involved were as succ...

Protein averts cell suicide but might contribute to cancer

...4, often makes errors when copying the genomic DNA sequence that later might cause the cell to become cancerou... For this research, Fiala developed a new way to sequence very short lengths of DNA. "This allowed us to pin down exactly what mistakes Dpo4 makes," he says. ...

Faster, low cost sequencing technologies needed to drive era of personalized medicine

... days. "If you want to develop a technology to sequence an individual genome for $1,000, you have to think...'s technological vision would enable scientists to sequence billions of base pairs of DNA in a single day. This is the size of an average mammalian genome and i...

New study aims to stop sepsis in its tracks

...nose, and treat sepsis. The protocol includes a sequence of resuscitation methods to deliver fluids, restore blood pressure, and monitor cardiovascular function and other organ activity. It was developed several years ago by Emanuel Rivers, M.D., M.P.H., a researcher and physician at Henry Ford Hospital in...

Neuron cell stickiness may hold key to evolution of the human brain

...e were able to identify a series of human-specific sequence changes that have a high likelihood of turning gen... evolution has conserved a specific non-coding DNA sequence over many millions of years, the sequence is likely to function as a switch turning genes on or off....

Novel experiment documents evolution of genome in near-real time

...s during cell division. The precise changes in the sequence of DNA subunits were determined with comparative genomic sequencing technology from NimbleGen Systems, and further analyzed with technology from Sequenom Inc., a San Diego-based biotech company. "This straightforward approach to the study of experi...

Molecular atlas provides new tool for understanding estrogen-fueled breast cancer

... estrogen-driven tumors. "For the most part, the sequence of steps between the activation of the estrogen receptor and the beginning of tumor cell division has been unclear. We've known of only a handful of the portions of genes that bind to the ER -- the so-called control regions that activate or deactivat...

Hundreds of thousands of viral species present in the world's oceans

...g (a technique that enables collection of many DNA sequence reads for less cost than conventional sequencing) to large samples, rather than individual organisms to gain insights into diversity, geography, taxonomy, and ecosystem functioning. This approach identified tremendous viral diversity with greater tha...

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