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Tag: "sequence" at biology news

Bacteria control how infectious they become, study finds

... It's only when RfaH finds the appropriate target sequence on a bacterium's DNA that this small portion of the protein is unmasked and can then turn on a select group of genes. These genes let disease-causing bacteria infect their host while at the same time protecting the bacteria from the host's immune def...

Wired for sound: How the brain senses visual illusions

...de is that the illusion depends on a rapidly timed sequence of interactions between the auditory and visual cortical areas." "This is part of a set of new findings by scientists in the field that show how integration of multiple sensations can happen much more rapidly than we thought before," said Mishra....

Rapid, Low-Cost DNA Testing

...ermines whether a fluorescently-tagged short probe sequence of single-stranded DNA matches a sequence in the target analyte. When it does not, the fluorescently tagged probe adsorbs on a gold nanopartic...

Researchers discover gene crucial for nerve cell insulation

...ropathy. "The researchers have deciphered a key sequence essential to the assembly of myelin," said Duane A... neuropathies, Dr. Svaren said. Ultimately, the sequence of activating genes "switches on" the Schwann cell, which wraps the nerve axon, the arm-like project...

Darwin's famous finches and Venter's marine microbes

...sidues. Using structural modeling, and patterns of sequence conservation, Kannan was able to show that loss of one key residue could be compensated by changes around other conserved regions of the protein, and that some of these changes in bacterial kinases are also seen in specific human kinases. Says Man...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

...distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems....expression. It is amazing that the same nucleotide sequence can simultaneously encode its respective protein and modulate its level of expression." says Stoynov...

UBC researchers reveal dwarf aquatic plants' hidden ancestry

...Faculty of Land and Food Systems. "And it took DNA sequence evidence coupled with a critical re-examination of anatomy to assign these plants to their proper place in the plant evolutionary family tree." Graham and his PhD students Hardeep Rai and Jeffery Saarela, who is now a research scientist at the Can...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...year survival rates of all cancers. Wild type sequence p53 as a vaccination target for squamous cell carcinoma of the head and neck: Abstract 5113 Researchers from the University of Pittsburgh and the Gunma University School of Medicine have developed a vaccine that enlists multiple parts of the immu...

Researchers create artificial enzyme that mimics the body's internal engine

...s. The imitation site, which involves an elaborate sequence of 32 chemical steps, was built from scratch and took several years to develop. The site contains the three active centers found in the naturally occurring enzyme: an organic molecule called phenol, an iron atom and a copper atom. Working together...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

... dock with the MAVS proteins, thereby triggering a sequence of signals ending with the production of interferon beta?a potent inhibitor of virus replication. Recent research has shown that hepatitis C generates a protein called NS3/4A that chops up MAVS, interfering with immune signaling and possibly providin...

Sleep enforces the temporal sequence in memory

...ot clear how the brain keeps track of the temporal sequence in such memories: did Paul spill a glass of wine before or after Mary left the party? Previous findings from a research group headed by Jan Born at the University of Lübeck have confirmed the widely held view that long-term memories are formed part...

Scientists discover a new risk factor for Alzheimer's

...s research had revealed that APP is subjected to a sequence of cellular events that either properly recycles APP or shunts it into cellular structures called endosomes, where it is chopped into amyloid-beta. Researchers had identified several genes involved in this cellular sorting process. St George Hyslop a...

Stopping plants from getting sick

...raduate student all of his or her research time to sequence and characterize one gene. Now that we have sequenced the genome of a smut fungus, I can look through thousands of genes on my desktop computer." Kronstad is now using his NSERC-funded research as a foundation to fight an outbreak of the yeast fun...

Small molecule dervived from Rb2/p130 could act as cancer therapeutic

...discovered that within Rb2/p130's spacer domain--a sequence of 212 amino acids located in the pocket or middle...was a small portion that resembled an amino-acidic sequence contained in the protein p21, which acts as a cdk (cyclin dependent kinase) inhibitor. Cdks play a ...

Scientists perform 'tricky' operation

...eam of 65 scientists that worked on the project to sequence the genome, which could offer clues to better trea... drug resistance. "The completion of the genome sequence by The Institute for Genomic Research (TIGR) and subsequent annotation of the genome database has op...

Susceptibility to Crohn's disease -- an important new clue

...00,000 single nucleotide polymorphisms (SNPs) ?DNA sequence variations occurring when a single nucleotide in the genome differs between members of a species ?Cécile Libioulle et al. identified a new susceptibility locus for Crohn’s disease. Their results are published online in the open-access journal PLoS Ge...

Triplex assay used to assay duplex genomic DNA

Direct detection of base sequence in duplex nucleic acid has long been an unfulfille...stic assay allows for the direct detection of base sequence in human genomic duplex samples, thereby obviating the use of PCR which has inherent problems and is...

Will the plague pathogen become resistant to antibiotics?

...found in the plague bacillus Yersinia pestis, gene sequence researchers report. The ability to resist many of the antibiotics used against plague has been found so far in only a single case of the disease in Madagascar. But because the same ability is present in other kinds of bacteria from a broad range o...

DNA analysis reveals rapid population shift among Pleistocene cave bears

...ne era. The findings illustrate the ability of DNA sequence analysis to reveal aspects of animal population dy...teeth ultimately provided useful mitochondrial DNA sequence (mitochondrial DNA is especially useful for tracking population changes). The findings indicated tha...

Scientists discover new virus caused deaths of transplant recipients from single donor

...d in the U.S. each year. Knowledge of the genetic sequence of this virus will enable improvements in screening that will enhance the safety of transplantation. Ian Lipkin, MD, director of the Greene Laboratory and Principal Investigator of the Northeast Biodefense Center, emphasized the importance of acad...

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