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Tag: "sequence" at biology news

One species, many genomes

...in many traits (the background shows schematically sequence variation in the DNA of these plants). To track ...s," says Weigel. He adds "The insight that the DNA sequence of a single individual is by far not sufficient to understand the genetic potential of a species als...

Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring

... in mice that smoking can cause changes in the DNA sequence of sperm cells, alterations that could potentially be inherited by offspring. The results of their study are published in the June 1 issue of Cancer Research, a journal of the American Association for Cancer Research. “Here we are looking at male...

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

...fMDR1 gene. They first obtained the PfMDR1 protein sequence from the NIH PubMed data base. They then "back translated" the protein sequence using a computer program to change the parasite gene sequence − which combines nucleotide base pai...

New collaborative research reveals chimpanzees can sustain multiple-tradition cultures

...nce, the majority of the chimpanzees followed that sequence for the remainder of the testing period. Over time, the different methods chosen by each high-ranking female were passed among members of her group, thereby becoming a local tradition. In all, the researchers observed 10 traditions spread through...

Researchers reveal structure of protein altered in autism

...ause of the similarity in structure and amino acid sequence with acetylcholinesterase....

New findings challenge established views on human genome

...treat and prevent disease. Having the human genome sequence is similar to having all the pages of an instructi..., researchers have made major strides in using DNA sequence data to identify genes, which are traditionally defined as the parts of the genome that code for pro...

454 sequencing identifies HIV drug resistance at early stage

...nter at the University of Minnesota correlated the sequence data with the patient outcomes, to which 454 Life ...ntly generate hundreds of thousands of long clonal sequence reads that accurately enable the sensitive detection of rare mutations” explained Egholm Michael, Ph...

Exploring the dark matter of the genome

... that are 10 kilobases long. Contiguous lengths of sequence are assembled by matching overlaps of these fragme... Thus the first "substantially complete" genome sequence of Drosophila, published in Science in March, 2000 by the Berkeley Drosophila Genome Project and Cel...

Potent possibilities for parasite attack

...ucocutaneous leishmaniasis, respectively, with the sequence they produced in 2005 for L. major, which causes a...y pressure over time to maintain the structure and sequence of the Leishmania genomes - the degree of similarity between these species was unexpected," explaine...

Gene responsible for common hearing loss identified for first time

...cleotide polymorphism) analysis, or looking at DNA sequence variations occurring in a single nucleotide, A, T, C or G, to study a large patient and control population from Belgium and The Netherlands. They found significant results for an amino acid changing SNP inTGBF1, and that this remained significant aft...

Mutating the entire genome

...gineer a mouse with a particular gene or other DNA sequence knocked out. So using existing technology to knock out the estimated 20,000 mouse genes would cost $200 million, and knocking out the roughly 300,000 non-gene DNA sequences in mice would cost $3 billion, he adds. The new method is a faster, cheap...

Weizmann Institute scientists develop a general 'control switch' for protein activity

...a short segment of amino acids into the amino acid sequence making up the protein. This segment is capable of binding strongly and selectively to a particular chemical drug, which affects the activity level of the engineered protein by increasing or reducing it. When the drug is no longer applied, or when it ...

Human genetic 'deserts' are teeming with significant life

...ysing it in its entirety. Although the finished sequence of the human genome announced in 2003 was a great ...nswered. Before the information contained in the sequence can be used to its best effect, the identity and precise location of all the protein-encoding and no...

Genome of Clostridium botulinum reveals the background to world's deadliest toxin

...ents, one of which is known as Botox®. The genome sequence shows that C. botulinum doesn’t have subtle tools ...ow until the next host comes along." The genome sequence is peppered with genes that produce enzymes to digest proteins and other animal material in the soil...

The sound of proteins

...ome.html ]. The browser allows anyone to send in a sequence coding for a protein that is then converted into music and returned to the inquirer as a midi file....

Corals -- More complex than you?

...plored, Prof. Miller says. "There is no project to sequence the coral genome, in spite of the tremendous benefits to medicine and other branches of science such a project would offer. "There has never been a "home grown" genome project. The genomes of several iconic Australian species have been sequenced o...

New technique will produce a better chromosome map

...s will help them tease out the relationship of the sequence to the physical structure. The new approach will allow scientists to answer fundamental questions about chromosome structure, Novikov said. Such questions have relevance across species. ...

Gene mutation linked to cognition is found only in humans

...s note. They identified a region of the chimpanzee sequence that has a weakening effect on the splicing site that also probably applies to humans. "It is likely that both the creation of novel splice form and the weakening of the constitutive splicing contribute to the splicing pattern changes during primate ...

WHO data confirms low level of resistance to Tamiflu

...tested by neuraminidase inhibition assay (IC50 or sequence analysis) to detect mutations associated with drug-resistance. Results were as follows: Influenza Season in Japan No of Influenza A isolates tested Resistance No of Influenza B isolates tested Resistance 2003/2004 1180 3 (0.3%) 171 0 2...

UCLA AIDS Institute researchers find a peptide that encourages HIV infection

... RC-111 is also cyclic and has the same amino acid sequence as retrocyclin-1. In both peptides, the amino acids are strung like 18 beads along the molecule's backbone. The amino acids in RC-111, however, are in reverse order. The researchers had initially wanted to quantify previous research by Dr. Robert...

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