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Tag: "sensitivity" at biology news

One-of-a-kind imaging probe reveals secrets useful for drug discovery

... 600 megahertz is fairly standard, but the extreme sensitivity of the probe - the component that is inserted into... enormous progress - it has thousands of times the sensitivity it used to have. The findings in Florida represent the great improvement that has taken place in the...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...AMPK), a metabolic regulator that promotes insulin sensitivity and fatty acid oxidation. It's been shown in previous work that the lifespan of worms has been extended by the addition of copies the AMPK gene, and chronic activation of AMPK is seen on calorie-restricted diets. The researchers examined the livers o...

A potential biological cause for sudden infant death syndrome

...ught to help coordinate breathing, blood pressure, sensitivity to carbon dioxide, and temperature during waking and sleep. When babies sleep face-down or have their faces covered by bedding, they are thought to re-breathe exhaled carbon dioxide, therefore breathing in less oxygen. Normally, the rise in carbon di...

Cancer cells forming blood vessels send their copper to the edge

...cancer therapy. Yet, the biological basis for this sensitivity of angiogenesis to copper has been an enigma. In search of an answer, researchers from the Biosciences and X-ray Science divisions at Argonne and the Department of Medicine, Section of Hematology/Oncology, at the University of Chicago, have used X...

UCLA: How does your brain respond when you think about gambling or taking risks?

... psychology. "The people who show much more neural sensitivity to losses relative to gains are the same people who are very reluctant to gamble unless they are offered extremely favorable gambles. The people who are about as sensitive to losses as gains neurologically are the ones who are more willing to gamble....

MIT's ocean model precisely mimics microbes' life cycles

...which differ primarily in their size, and in their sensitivity to light, temperature and nutrient availability, then allows the ocean to self-select those most fit for survival in any particular area. What emerged after the model completed its 10-year virtual evolution -which took four to five days on a clust...

New nanotechnology able to examine single molecules, aiding in determining gene expression

...ate and identify individual transcript molecules—a sensitivity not achieved with earlier methods. "Gene expression profiling is used widely in basic biological research and drug discovery," said Jason Reed of UCLA's Department of Chemistry and Biochemistry and the study's lead author. "Scientists have been ha...

Fish growth changes enhanced by climate change

...d climate change. Heavy exploitation increases the sensitivity of species to environmental effects and could be magnifying the effects of long-term climate change and short-term climate variability on the viability of some species. He said correlations for long-lived shallow and deep-water species suggest tha...

New sensor detects gaseous chemical weapon surrogates in 45 seconds

...ence, we have potential for extraordinary chemical sensitivity and selectivity," Wojcik said. QPAS's small components represent a major advance over previous LPAS measurement methods. Historically, LPAS instruments were physically large, often measuring a meter or more in length. The entire arrangement was cu...

Molecular signature may identify cisplatin-sensitive breast tumors

...common sporadic triple-negative tumors shared that sensitivity was unknown. The current study was designed to an...ole of p63/p73 expression in determining cisplatin sensitivity will be led by MGH researchers through the Dana-Farber/Harvard Cancer Center. Starting in Boston in...

Gene expression test reveals ER and HER-2 status of breast tumors

...he ER and HER2 receptor status, and also gauge the sensitivity of the tumor to hormone therapy and chemotherapy," says Lajos Pusztai, M.D., Ph.D., associate professor in the M. D. Anderson Department of Breast Medical Oncology, and team leader with Symmans. ER-positive tumors are treated with estrogen-suppre...

Common blood test can help distinguish between mononucleosis and tonsillitis

...termined that a ratio higher than .35 would have a sensitivity of 90 percent and a specificity of 100 percent for...sis 100 percent of the time. "The specificity and sensitivity of this test seem to be better than the mononucleosis spot test itself," the authors write. "In c...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...ound 164 genes that are involved in regulating the sensitivity of squamous cell head and neck cancer cells to lap...ates that may be useful in determining a patient’s sensitivity or resistance to Tykerb, and the results have revealed several sensitizing drug targets that reveal ...

Bioluminescence at the service of a novel cerebral imaging technique

...psoid body have thus demonstrated the considerable sensitivity of this novel approach, while validating access to all structures, even those located deep in the brain. It will therefore be possible to study all neurons or cerebral structures using this approach. This novel technique opens numerous perspecti...

Penn study on olfactory nerve cells shows why we smell better when we sniff

...hing. "The mechanosensitivity may increase the sensitivity of our nose, especially when stimulated by weak odors," says Ma. "It helps the brain make better sense out of odor responses when it integrates airflow information. We still don't know how it happens, but sniffing is essential for odor perception." ...

Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex

...As we get better at doing the extractions, and the sensitivity of the instruments and techniques improve, I anticipate that we’ll be able to get from comparably aged species much more extensive sequences and to get novel sequences unique to that species, which will give us ideas about the relationship between sp...

A new study of living cells could revolutionize the way we test drugs

...s*. Unfortunately, these modifications reduced the sensitivity of the technique, and the normal activity of the y...e already have some ideas about how to improve the sensitivity of the detector in water and next time we will also use a more active micro-organism such as an amoe...

Research finds music training 'tunes' human auditory system

... instrument significantly enhances the brainstem’s sensitivity to speech sounds. This finding has broad implications because it applies to sound encoding skills involved not only in music but also in language. The findings indicate that experience with music at a young age in effect can "fine-tune" the brain...

Scientists find hormone activity explains adolescent mood swings

...bunit, such as alpha4-beta2-delta, has the highest sensitivity to steroids. In order to study its role in puberty, the researchers used a mouse model that reliably predicts the human condition. In this rodent model, the alpha4-beta2-delta receptor normally has very low expression, but increases dramatically at t...

3-D ultrasound identifies women at risk for impending preterm birth

...with high diagnostic accuracy. "The high accuracy, sensitivity and specificity of the adrenal gland volume in predicting preterm birth within five days from the time of examination proves that 3-dimensional ultrasound evaluation of the fetal adrenal gland has the desired test characteristics to define a populati...

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