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Tag: "sensitive" at biology news

Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

...e BRAF mutation and some with the RAS mutation are sensitive to drugs that inhibit MEK," explained Dr. Neal Rosen, Professor of Medicine and a member and laboratory head in the Molecular Pharmacology and Chemistry Program at Memorial Sloan-Kettering and the study's senior author. "Translating these findings in...

Gene expression profile helps predict chemotherapy response in ovarian cancer patients

...urgery. (Second-look surgery is currently the most sensitive investigational approach for detecting residual disease in patients with advanced ovarian cancer who have achieved a complete clinical remission following chemotherapy, explains Cannistra.) The expression of 93 genes, collectively referred to as the...

Stress substantially slows human body's ability to heal

...r minor wounds says that wound-healing is a really sensitive process." Glaser added, "This supports our long-held contention that even small changes in cytokine levels will have a marked effect on health." William Malarkey, professor of internal medicine; Stanley Lemeshow, dean of the School of Public Heal...

Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack

...nd had a relatively long follow-up period based on sensitive assessment methods of left ventricular function and infarct size. In conclusion, use of G-CSF therapy to mobilize bone marrow–derived stem cell does not improve left ventricular recovery in patients with acute myocardial infarction after successful m...

Portable cocaine sensor developed at UC Santa Barbara

...parts per million in blood. Still, this is not yet sensitive enough for use in the emergency room, since a person with .3 parts per million of cocaine in their blood would be considered "stoned on cocaine." So more work needs to be done to increase the sensitivity of the new test. Last summer was the first ti...

Swiss researchers develop all-in-one remote control gene expression tool

...he gene expression in vivo in an extraordinary and sensitive way." ...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

... paramagnetic iron oxide particles, which are very sensitive to the magnetic fields used during MRI. Wu injected the MPIO or USPIO particles into rats that had received heart transplants three days earlier. Macrophages, which typically ingest foreign materials inside the body (bacteria, for example), incorpora...

Infection 'alarm' yields clues to immune system behavior

...f Biological Chemistry. "We were surprised by how sensitive cells were to small amounts and brief exposures to...thways that pick up this signal act like extremely sensitive radio receivers. They can pick up the alarm message from exposure to even a very small amount of TNF...

New evidence questions the simple link between prion proteins and madcow disease

...ransferred into the villi. When they used a highly sensitive version of Western Blot analysis to examine the contents of this pre-digested mixture, they found only the faintest suggestion that some of the PrP had survived. This was despite the fact that the original mixture had a contained a high level of PrP....

Ultrasounds show mothers' drinking shrinks fetal brain

... ultrasound examinations that would have been more sensitive to the pre-recognition drinking," said Handmaker. The authors say that while women's own reports of their drinking habits may not be entirely accurate, the study findings are consistent with other research on fetal alcohol exposure in animals and h...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...as antibody dependent cell cytotoxicity (ADCC), is sensitive to the composition of sugars (or "glycans") in the antibody's constant region. Moreover, in the absence of these sugars, the antibodies can bind to antigens but do not elicit ADCC. "Mammalian cell cultures currently used for most therapeutic protein...

The Amazon in 2050: Implementing the law could save a million square kilometers of rainforest

... By developing the first empirically-based, policy sensitive model of Amazon deforestation to assess forest losses within major watersheds, eco-regions, vegetation types, and the geographic ranges of 382 mammal species, two extreme scenarios were developed, encompassing the likely range of future trajectories ...

Warming trend may contribute to malaria's rise

...icroorganism that causes the disease are extremely sensitive to changes in temperature, some scientists have speculated that rising average temperatures may be making conditions more favorable for mosquitoes and pathogen development, leading in turn to the surge in malaria cases. But a 2002 study found no sig...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

... strand break -- which is very small. It is a very sensitive communication pathway." Method To investigate ...gineered strain of mice lacking MDC1 was extremely sensitive to DNA damage -- and unable to repair it. The MDC1-deficient mice showed symptoms of growth retardat...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

...als. What's more, this molecule –called Rev-erb?is sensitive to lithium and may help shed light on circadian rhythm disorders, including bipolar disorder. The findings, which also provide insight into clock-controlled aspects of metabolism, are reported in this week's issue of Science. "We're interested in th...

Ancient DNA provides clues to the evolution of social behavior

...understanding of population genetic theory and how sensitive it is to real-life events,'' Hadly explains. Most of the work conducted in Hadly's lab focuses on using ancient DNA to examine how living species have responded to climate change in the past. With this information, she hopes to gain insights into th...

Behavioral studies show UV contributes to marsupial color vision

...m based on two types of cone photoreceptors--those sensitive to short (SWS) and medium-to-long (M/LWS) waveleng... presence of three spectrally distinct cone types, sensitive to short (SWS), medium (MWS), and long (LWS) wavelengths, is a common feature of Australian marsupia...

Study: Competition for sex is a 'jungle out there'

...well," Knight said. "We show that these areas are sensitive to pollen limitation just because they are diverse. Any perturbation in the tropical areas -- and there are lots right now ?is going to hurt the situation even more than we think and perhaps drive certain species to extinction." ...

Sea coral's trick helps scientists tag proteins

...four years ago. "All known Kaede-like proteins are sensitive to ultraviolet light irradiation, which results in...n from green to red fluorescence, but they are not sensitive to blue light," Konstantin Lukyanov said. So the researchers did not expect Dendra to be activated ...

Alternatives to the use of nitrate as a fertiliser

...ffect of ammoniacal nutrition on the metabolism of sensitive plants, such as spinach and on tolerant ones, like the pea. The results indicate that the processes associated with tolerance to ammonia in the pea are multiple with respect to spinach. In the pea plant there is greater regulation of the absorption o...

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