Tag: "selectivity" at biology news

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

... far from sufficient to account for the incredible selectivity of polymerase II, Kornberg said. And the scientists didn’t know either how the polymerase avoids substituting the NTPs that constitute DNA for the correct RNA building blocks, molecules that differ by only one oxygen atom. In search of an explanati...

Motorola researchers develop selective sensors based on carbon nanotubes

...eport the advance in a paper, "Tuning the chemical selectivity of SWNT-FETs for detection of heavy metal ions," w...various chemical species with high sensitivity and selectivity while carbon nanotubes are well known for their electronic properties." The peptides are made of 2...

Study offers innovative profile of enzyme that aids tumor growth

...against many enzymes in parallel, both potency and selectivity factors are assigned simultaneously. The development of a selective inhibitor of KIAA1363 was possible due to the availability of an activity-based proteomics probe for this enzyme. Such probes are now available for many enzyme classes that partic...

'Word-vision' brain area confirmed

...nguage abilities," reported the researchers. "Such selectivity may be difficult to observe in patients with more ...s precious support to the idea of partial regional selectivity for word perception in the ventral cortex," they wrote. Importantly, the researchers observed that ...

Mapping alcohol brain damage

...e most neurological diseases also exhibit regional selectivity of pathology." Professor Dodd said researching proteins was the next step as that would tell them why some cells have impaired function. He has also teamed up with United Kingdom colleagues to find out why people get addicted to alcohol -- with t...

Cells direct membrane traffic by channel width

...ule is out of luck. The point of entry, known as a selectivity filter, is the most narrow, but there are other tight barriers blocking the way as well, said Emad Tajkhorshid, assistant director of research in the Beckman lab. "Membrane proteins are difficult to crystallize," he said. "We don't have the known st...

Nanowires can detect molecular signs of cancer, scientists find

...at allow rapid detection of many markers with high selectivity and sensitivity. "Genomics and proteomics research has elucidated many new biomarkers that have the potential to greatly improve disease diagnosis," the scientists write. "The availability of multiple biomarkers is believed to be especially importan...

Researchers seek to discover what really happens when a virus enters the body

...ything that does damage as dangerous. Through this selectivity process, the immune system does not respond to things that don't do damage. Examples she uses to support her thesis that the body recognizes some invading substances are not dangerous include the development of a fetus during a woman's pregnancy an...

Anthrax inhibitors identified by Burnham team

...ucturally similar to LF. This is very important as selectivity is a fundamental prerequisite for a drug to be safe for use in humans. Three lead compounds where tested in mice infected with anthrax spores, in combination with the antibiotic Ciprofloxacin. The survival rate for mice treated with each of the comp...

Columbia research lifts major hurdle to gene therapy for cancer

...is really starting to make a comeback."The virus's selectivity for cancer cells is based on two moleculescalled PEA-3 and AP-1 that, the researchers found, are usually abundantinside cancer cells. Both of the molecules flip a switch (called PEG)that turns on the production of a cancer-inhibiting protein uniquely...

Chemists create 'Superbowl' molecule; May lead to better health

...These new molecules have much greater capacity and selectivity than their predecessors and show more promise for wider applications." "I wanted a name for our compounds which acknowledged this and recognized their larger size and shape," says Sherburn. "'Superbowl' was perfect since it conjures up ?for me at le...

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