Tiny clue reveals new path toward heart disease
...he disease. They found just such a region: a small section of the long arm of chromosome 3 where just a handf...NA samples, the researchers scanned the same small section of chromosome 3 for SNPs that differed in sequence between individuals with and without coronary hea...Small molecule dervived from Rb2/p130 could act as cancer therapeutic
...of 212 amino acids located in the pocket or middle section of the gene--was a small portion that resembled an amino-acidic sequence contained in the protein p21, which acts as a cdk (cyclin dependent kinase) inhibitor. Cdks play a critical role in cell cycle regulation. "What we tested was the ability of...FSU researchers determine a critical factor in workings of proteins
...bo, chief of the Theoretical Biophysical Chemistry section of the National Institutes of Health, described the Structure paper as "the most comprehensive investigation yet conducted of protein-protein association rate. It provides convincing evidence that the remarkable simplification of the calculation of a...Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps
...and human genomes. Published April 13 in a special section of the journal Science, the analysis reveals that the three primate species share about 93 percent of their DNA, yet have some significant differences among their genes. In its paper, the Rhesus Macaque Genome Sequence and Analysis Consortium, suppo...'Guardian of the genome' protein found to underlie skin tanning
...s p53. When Fisher and his colleagues examined the section of the gene for POMC that promotes production of the protein, they found it meshed nicely with p53 ?suggesting that when p53 docks there, it revs up POMC production. Additional evidence came when the researchers exposed human and mouse keratinocytes ...Study shows dramatic increase in Caesarean sections
... and obstetric problems which may need a caesarean section are higher in uninsured women. "The increase in caesarean rates also has a significant impact on health costs in both the public and private sectors." Report co-author, obstetrician Craig Pennell from the School of Women's and Infants' Health a...Researchers develop way to calculate speed of bacterial sex
...May 2007 issue of Vadose Zone Journal in a special section on soil biophysics. Researchers believe that one of the major mechanisms for the transfer of genetic information in the environment occurs through a conjugation. According to study co-authors, Timothy Ginn and Arash Massoudieh, donor bacteria cell...Researchers attach genes to minichromosomes in maize
...e contains only centromeres and telomeres, the end section of a chromosome, with little else. However, minichromosomes have the ability to accept the addition of new genes in subsequent experiments. Birchler said there have been unsuccessful efforts to create artificial chromosomes in plants but this is t...Premature births may be linked to seasonal levels of pesticides and nitrates in surface water
... School of Medicine. Dr. Lemons is director of the section of neonatal-perinatal medicine at the IU School of...he Riley Hospital for Children of Clarian Health's section of neonatal-perinatal medicine. ......heel," the researchers developed a method to cross section the front and back of the chemotactic cell in order to analyze the components of its protein network. The cell fractionation equipment developed in Klemke’s lab is the first method to enable researchers to study the entire network of signaling prote...Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin
... easily available from donors undergoing Caesarian section deliveries in UTMB hospitals. "However," he added, "embryonic stem cell research was absolutely necessary to teach us how to do this." Embryonic stem cells have been engineered to produce cardiac, neural, blood, lung and liver progenitor cells ...St. Jude study shows genes play an unexpected role in their own activation
... a transcription factor—a molecule that binds to a section of DNA near a gene and triggers that gene to make the specific protein for which it codes. CREB activates genes in response to a molecule called cAMP, which acts as a messenger for a variety of stimuli including hormones and nerve-signaling molecules...New findings challenge established views on human genome
...gically selected to provide a representative cross section of the entire human genome. All told, the ENCODE consortium generated more than 200 datasets and analyzed more than 600 million data points. “Our results reveal important principles about the organization of functional elements in the human genom...Rising skin cancer rates are more likely to affect wealthy people, says 12-year review
... “Although our research highlights that some section of society face greater risks than others, the safe sun message is one that we all need to heed if we are to halt rising skin cancer rates” concludes Dr Hoey....