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Tag: "search" at biology news

Speeding discovery of the 'human cancer genome'

...light one way to speed through the human genome in search of those genes most important for spawning cancer. Both groups say that a critical element in the enterprise to efficiently characterize the "human cancer genome" --a comprehensive collection of the genetic alterations responsible for major cancers--...

New potential drug target in tuberculosis

...ive strategy for a drug." The scientists will now search for compounds that can do so. At the same time, they are continuing to look for other proteins as drug targets. Wilmanns and his colleagues from various other institutes are now focusing on structures of molecules that help M. tuberculosis to persist...

New human retrovirus originated in mice

...ournal, Public Library of Science Pathogens. The search for the new virus began when Silverman and his colleagues provided samples of a rare familial prostate cancer in which the viral-defense gene, RNASEL, had been mutated in a specific way. This mutation compromised the function of the enzyme produced b...

New fruit fly protein illuminates circadian response to light

...person who has prolonged jetlag," notes Sehgal. In search of answers to the mutant's defective circadian response to light, Sehgal and colleagues looked to the molecular details of the clock cells in the jetlag flies. When a fruit fly is exposed to light, a photoreceptor called cryptochrome (CRY) transduc...

First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown

...chondria and myofibrils opens a new possibility to search for drugs capable of increasing cardiac contractility," Veksler said. *Presentations: The paper, "Direct mechanical communication between mitochondria and nucleus in cardiac cells," was chosen to be part of the "Physiological Genomics of Skeletal Mu...

Mystery solved: Gold's power against autoimmune diseases defined

...thor Stephen De Wall, PhD, undertook a large-scale search for new drugs that would suppress the function of ...es, Lupus, and rheumatoid arthritis. During their search through thousands of compounds they found that the known cancer drug, Cisplatin, a drug containing t...

Inside rocks, implications for finding life on Mars

...to look at microscopic fossils inside the rocks to search for signs of life, such as organic cell walls. These techniques would not destroy the rocks. "It's astounding to see an organically preserved, microscopic fossil inside a rock and see these microscopic fossils in three dimensions," said Schopf, who ...

A step forward in the fight against bacterial infections

...istant to the pre-eminent remedy; antibiotics; the search for new remedies against bacterial infections is in high gear. Research by scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to Ghent University shows that certain mice, by nature, can withstand particular bacte...

Is the brain wired for faces?

...niques to distinguish between people as it uses to search for differences between other groups of objects, such as plants, animals and cars. The study, published in the April 6 edition of the journal Neuron, adds new evidence to the debate over how the brain understands and interprets faces, an area of ne...

Statins have neutral effect on risk of cancer

...ital, Hartford, Conn., and colleagues, conducted a search of the medical literature from 1966 through July 2005 to identify randomized controlled trials of statins. They found 27 articles (n = 86,936 participants) that met their criteria for inclusion, reporting 26 randomized controlled trials of statins ...

Scientists discover new genetic subtypes of common blood cancer

... a normal blood cell with various myeloma cells in search of differences. The goal was to identify recurrent copy number alterations ?hotspots on the chromosomes where genes were abnormally duplicated or lost across many different tumors. The CGH analysis netted a large number of areas showing such altera...

Gene variation increases SIDS risk in African Americans

...rican adults with no known health problems. Their search focused on abnormalities in a gene called SCN5A, which has been associated with abnormal heart rhythms. Overall, the team found common and rare changes in this gene in five percent of SIDS deaths in African Americans. One specific variation, known a...

Most human-chimp differences due to gene regulation ?not genes

...from each of the four species. They focused their search on expression levels of two sets of genes, those that remained largely unchanged across all four species, suggesting that there was little room -- or need -- for improvement, and those that changed most dramatically, usually in the human lineage -- a...

Scientists make first step towards 'holy grail' of crystallography

.... Although there has been considerable research in search of a universal nucleant, this is the first time we have designed one which works on a large number of materials." The researchers plan to commercialise this discovery using Imperial Innovations, the College's technology transfer company. ...

Creation of antibiotic in test tube holds promise for better antibiotics

...ngs may turn out to be golden "in the never-ending search for blockbuster antibiotics." ...

NHGRI announces new sequencing targets

...ic variation, or haplotypes, designed to speed the search for genes involved in common diseases. The HapMap identified neighborhoods of tiny changes in DNA ?known as single nucleotide polymorphisms (SNPs) ?that can be involved in human disease. The structural variation effort will seek to identify instances...

Genomics-based vaccine could prevent deadly cattle disease

...-Liggett, also of TIGR, relied on known biology to search T. parva 's genome for potential vaccine proteins. First, scientists know that immunity to the parasite, and thus East Coast fever, emerges from immune system cells known as killer T cells. Second, they know that T. parva is an intracellular patho...

U-M scientists identify major psoriasis susceptibility gene

...us study, Nair and his U-M colleagues narrowed the search for the PSORS1 gene down to a 300,000-base-pair se...s. Further analysis by U-M scientists narrowed the search down to one gene, HLA-C, and one specific disease-causing allele, HLA-Cw6. Drugs used to treat psor...

Flu not the only germ threat this time of year

...t home. While investigators like Falsey and Walsh search for a vaccine against RSV, and a better way to check people who may have the illness, for ordinary people the effects and treatment are largely the same, whether a person gets the flu, RSV, the common cold, or another respiratory ailment. Feel crummy...

The urban evolution lab

...e of Alzheimer patients is a central factor in the search for a therapy for Alzheimer's disease. A lot or n... taken into account in diagnostic tests and in the search for new medicines. ...

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