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Tag: "search" at biology news

Gene screen for breast cancer better than pathologist's 'eye'

...ve tested their screening tool on breast fluid, in search of cells shed from growing tumors. "This screening method can see what the eye cannot see," says Sukumar, who is the Barbara B. Rubenstein Professor of Oncology at the Johns Hopkins Kimmel Cancer Center. "It can be a valuable tool, in combination...

MatBase -- A new transcription factor knowledge base released by Genomatix

...ontained in MatBase for performing TF binding site search in regulatory DNA sequences. Each single matrix is optimized for a minimum number of false positive results in non regulatory DNA. ...

Cells use mix-and-match approach to tailor regulation of genes

...iption factors a powerful new tool to narrow their search to the most promising candidates." ...

Study identifies new role for breast cancer susceptibility gene

...ornia, Irvine, designed a series of experiments to search for genes that are regulated by BRCA1. The researchers used microarray analyses to identify genes repressed by BRCA1 or a related tumor suppressor, CtIP, in mammary epithelial cells (MECs). Among the 12 genes inhibited by BRCA1 or CtIP was the gene...

Schepens scientists are first to discover angiogenesis switch inside blood vessel cells

...Two of those enzymes are PI3K and PLCg, which then search for their favorite lipid to use in their respective missions. Until the present study, scientists did not know exactly what those missions were and how they were accomplished. Kazlauskas and his team were determined to answer those questions. To d...

Researchers link two more genes to sudden infant death syndrome

...e, SCN5A, linked to SIDS. In 2005, a comprehensive search of the five channel genes that cause a potentially...percent to 15 percent of SIDS provide one place to search for a possible explanation. For families that have lost an infant to SIDS, it would be reasonable fo...

When the going gets tough, slime molds start synthesizing

... recalled, "One night I performed a bioinformatics search to look for genetic evidence that would suggest the existence of a type III PKS in Dictyostelium." Using various computer programs to find, assemble, and translate in silico the relevant raw DNA sequencing fragments first into genes then into the pro...

CHAVI announces international search for genes affecting HIV response

...ce. Typically, scientists use genetic analysis to search for minor changes in the sequence of 3 billion DNA letters that make up the human genome. The changes, called single nucleotide polymorphisms (SNPs), are like single-letter variations in the spellings of a word. The SNPs cluster in local neighborhood...

'Signature' of chromosome instability predicts cancer outcomes

...ven tumor sample." The technique may help in the search for cancer drugs that reduce chromosomal instability -- an approach of increasing interest to researchers -- by making it possible to screen a large number of drugs for efficacy, Szallasi notes. With further development, the team's work could also fo...

Deep-water discovery

...rbor Branch's Johnson-Se-Link II submersible, will search for and collect marine organism samples from these new reefs in 2,000-2,900 feet of water to determine which produce chemicals with the potential to treat human diseases such as cancer or Alzheimer's disease. The State of Florida's "Florida Oceans I...

Buckyballs boost antibody's chemotherapy payload

In the ongoing search for better ways to target anticancer drugs to kill tumors without making people sick, researchers find that nanoparticles called buckyballs might be used to significantly boost the payload of drugs carried by tumor-targeting antibodies. In research ...

Drug discovery team to explore newly discovered deep-sea reefs

... Florida's "Florida Oceans Initiative," will be to search for marine organisms that produce chemical compounds with the potential to treat human diseases such as cancer and Alzheimer's. "We've found incredible and surprising diversity at other deepwater reefs near Miami and Bimini, and some promising poten...

Protein clue to tailor-made antibiotics

...rsity of York have made a huge leap forward in the search for 'smarter' antibiotics. A research group in the Department of Biology has made a significant advance in understanding how bacteria use proteins to conduct a type of biological warfare. Bacteria like E. coli frequently try to kill each other w...

UCLA scientists strengthen case for life more than 3.8 billion years ago

...enland? "Akilia Island was not the best place to search for evidence of early life; it's simply the place where it turned up," Harrison said. "There's nothing special about Akilia Island," Manning said. "If life was there, it should have been abundant on Earth 3.83 billion years ago. The only place wher...

DOE JGI finishes 100th microbial genome

...and metabolism of the green sulfur bacteria." The search for microorganisms that can inform solutions to energy and environmental challenges can go to the extremes--the boiling hot pools in Yellowstone National Park, for instance--and lead to new biotechnology products. "DOE JGI has played an invaluable a...

Parkinson's disease mechanism discovered

...r colleagues believe their findings will guide the search for new drugs that suppress alpha-synuclein toxicity by enhancing the machinery of ER-to-Golgi transport. Thus, she said, they have already conducted a screen of 150,000 compounds for those with therapeutic potential. "We have found compounds that r...

Viral genetic differences are possible key to HIV dementia

..." The researchers also analyzed the sequences in search of a "genetic signature" common to the CNS-specific viruses in all 18 individuals, recounts Pillai. They found such a pattern, consisting of four amino acids, within a subregion of the viral envelope gene known as the V3 loop. "The identification o...

Study reveals how ADHD drugs work in brain

...nality. The finding could prove invaluable in the search for new ADHD treatments, and comes amidst deep public concern over the widespread abuse of existing ADHD medicines. "There's been a lot of concern over giving a potentially addictive drug to a child [with ADHD]," says lead author Craig Berridge, a ...

New genes implicated in rheumatoid arthritis

Researchers continue to search for genetic clues into rheumatoid arthritis (RA), a chronic inflammatory joint disease. While its specific cause is not yet known, RA has been linked to an inherited susceptibility. Interestingly, despite its strong genetic component, RA's occurren...

UAB researchers confirm HIV-1 originated in wild chimpanzees

...UAB), has discovered a crucial missing link in the search for the origin of HIV-1, the virus responsible for human AIDS. That missing link is the natural reservoir of the virus, which the team has found in wild-living chimpanzees in southern Cameroon. The findings provide important clues to how the disease ...

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