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Tag: "search" at biology news

Discovery of an HIV inhibitor in human blood points to new drug class

...ts with chronic kidney failure during dialysis, in search of those with anti-HIV activity. After sorting the more than one million blood peptides into 300 fractions, they focused on one that blocked HIV without toxic effects on cells. Further examination revealed VIRIP as the active ingredient. A synthet...

Scientists perform 'tricky' operation

...chers have access to a complete genome dataset the search for alternative drug targets can really take-off." Amazingly, the pesky parasite was found to have an exceptionally large collection of DNA, with the possibility of having more genes than humans. But Ms Dunne said while the sequencing of the g...

Primitive yeast yields secrets of human cholesterol and drug metabolism

...he same protein, but it works the same way.? The search for Dap1 began with the hunt for factors that infl...holesterol, narrowing down the territory for their search and giving them a telltale marker (the cholesterol) to track. Reasoning that whatever controls th...

Can engineered immune cells stop AIDS?

...utralizing antibodies that are roaming the body in search of foreign invaders. Faced with such a clever adversary, Wang wants to synthetically alter the HIV invaders and use their hollow shells as delivery vehicles to insert DNA that will counteract the infection. The "Cadillac" of this gene deli...

Speeding 'fingertip' discovery -- 20 years of protein info in 1 place

...n reported. The team then constructed an online search tool, PhosphoMotif Finder, which was incorporated into their previously established Human Protein Reference Database. Human Protein Reference Database now contains about 16,000 phosphorylation sites described in the literature and the PhosphoMotif Fi...

Gene hunters close in on Lou Gehrig’s disease

In the first genome-wide search for the genetic roots of the most common form of a...for sporadic ALS, our results seriously narrow the search and bring us that much closer to finding what we need to start developing treatments for the disease...

New evidence of 'human' culture among primates

...monkeys. As he approached, the monkeys would first search for a suitable loose stone, then hit it on a rock surface several times. The act was apparently an aggressive one, directed at Dr Moura as a potential predator, but as the group became used to his presence in the area the stone-banging decreased. ...

Anti-fungal drug stops blood vessel growth

...ntifungal drug would have such a role.? In their search for antiangiogenesis drugs, the researchers worked with cells from human umbilical cords, a rich source of blood vessels, and exposed them to 2,400 existing drugs - including FDA- and foreign-approved drugs, as well as nonapproved drugs that had pass...

Fruit fly gene research may shed light on human disease processes

...e more than pests—they may be allies in a fruitful search for clues to human diseases caused when genes malfunction. "One common misconception is that individual humans may carry 'disease-causing' genes, such as a gene for cancer," explains James Erickson, a biology professor at Texas A&M University. ...

Cancer cells forming blood vessels send their copper to the edge

...f angiogenesis to copper has been an enigma. In search of an answer, researchers from the Biosciences and X-ray Science divisions at Argonne and the Department of Medicine, Section of Hematology/Oncology, at the University of Chicago, have used X-ray fluorescence microprobe imaging at the Advanced Photon...

Virginia Tech's System X supercomputer provides super tool for simulation of cell division

...sively parallel versions of a deterministic global search algorithm, DIRECT, and a deterministic local search algorithm, MADS, to do the twiddling, and then combined the results. "A deterministic global search ...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

... to regenerate itself. It therefore stimulates the search for other strategies and more therapeutic targets in this expanding field of regenerative therapy," he added. LVADs are currently mainly used in those patients awaiting heart transplant, whose heart failure is very severe. The researchers are hope...

One-of-a-kind imaging probe reveals secrets useful for drug discovery

...e U.S. Department of Agriculture, could aid in the search for natural substances to make medicines. It also shows that scientists can obtain volumes of information from very tiny samples, which could be useful in efforts to understand Alzheimer's disease and other disorders. "There are many potent, useful ...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

...olecules that differ by only one oxygen atom. In search of an explanation in the current study, the researchers screened hundreds of crystals to achieve higher data quality and resolution than ever before. “In the course of the work, we saw something that had never been noticed before?additional protein...

Protein structure initiative launches new resources for the scientific community

...ll create an information hub where researchers can search for and submit structural information. Meanwhile, PSI scientists will continue to develop new methods and tools for protein structure studies that are being commercialized by industry for mainstream use. Information about protein structures can ...

Scientists crack genetic secrets of human egg

... human body. The computer work of this preliminary search will give way to further experiments. ...

Fruit fly study identifies gene mutation that regulates sensitivity to alcohol

...nse may translate into useful tools to advance the search for human genes involved in sensitivity to alcohol. Insights about sensitivity, or acute tolerance, are especially important because we know that people who are less sensitive to alcohol's impact are at greater risk for becoming alcohol dependent," h...

Selecting life: Scientists find new way to search for origin of life

...and geology," reflected Hazen. "It marries them to search for an answer to a question that has intrigued humanity since the birth of consciousness: How did we get here?"...

RNA map provides first comprehensive understanding of alternative splicing

...X-ray crystallographic studies. Unexpectedly, this search revealed four discrete peaks where the binding clu... co-authors Terry Gaasterland and Bahar Taneri, to search for new genes that had clusters of Nova binding sites. Of the 50 or so transcripts with such cluster...

One signal elicits thousands of answers

...forms of cancer. The new technology will allow the search for new data - which might not be necessary too soon. "Our study revealed more phosphorylation sites than all previous studies combined," says Mann. ...

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