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Genomic Analysis Uncovers New Targets for HIV Vaccine

...The researchers expect the new findings to aid the search for an HIV vaccine that would work by boosting the protective effects of one or more of these genes, and help the body's own immune system overcome an infection. One of the genes looks particularly attractive as a vaccine target. The study, publishe...

CSIRO scientists join fight to save 'Tassie devil'

...microarrays and a range of molecular techniques to search for infectious agents, markers for disease and to determine where the tumours originate. “We will be working in a number of areas including establishing whether a virus or other infectious agents are associated with the tumours,” AAHL’s Dr Alex...

The insect vector always bites twice

...the angle of allergic responses to bites or in the search for veterinary vaccines, constitutes now an important research path for new surveillance and prevention strategies. ...

Hormone helps mice 'hibernate,' survive starvation

...ultimately prove to be a vital part of the ongoing search for new therapies for human obesity and other metabolic conditions, Dr. Kliewer said. “Given that the PPAR-alpha receptor already is the target of drugs that work to boost high-density lipoproteins, or the ‘good’ cholesterol, and reduce the amount...

Research team identifies new Alzheimer's gene

... confirm additional LOAD susceptibility genes. The search revealed GAB2. Based on the genetics of this and other neuroscientific findings, researchers suggest the healthy form of the GAB2 gene may protect brain cells from developing tangles, one of the hallmarks of Alzheimer’s disease. If the findings ar...

Ancient DNA traces the woolly mammoth's disappearance

...the scene in large numbers until even later. In search of a general pattern in the new study, Barnes and Lister’s team looked to the extinct woolly mammoth. What they found, however, was an “interesting pattern, not like those of the other species.” Their genetic data indicate that Siberian mammoths e...

Breakthrough developments in rheumatoid arthritis reported

...has since gone on to use modern genetic methods to search for single nucleotide polymorphisms, or SNPs, to identify players that have fallen under the radar of older methods. The group has discovered another signaling molecule that seems to increase a person’s risk for rheumatoid arthritis by 30 percent. (T...

Exploring the dark matter of the genome

...uter programs to analyze the raw sequence data, in search of genes. We identified patterns of codons that might indicate a gene splice-site or a promoter, for example. We mapped experimentally derived evidence of messenger RNAs back to the matching heterochromatin sequence. And we looked for sequences simil...

In nature, proteins sweep up nanoparticles

...diameter. Their discovery could also refine the search for the earliest indications of life on Earth, as well as help determine whether planets like Mars once harbored life. Scientists involved in this research hunt for biosignatures, which are the telltale calling cards left behind by microbes that may ...

University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

...require multiple grafts. Thus, there is an ongoing search for the ideal small-caliber arterial substitute for revascularization procedures. The University of Pittsburgh team, led by David A. Vorp, Ph.D., associate professor of surgery and bioengineering and a faculty member of the McGowan Institute for R...

Warning from Asian bees

...rf in Cairns, three more swarms were found and the search widened. Already operating under marginal circumstances, many of Australia’s beekeepers can only afford a momentary sigh of relief. Asian bees (Apis cerana) are capable of carrying two types of Varroa mite – destructor and jacobsoni; the latter...

Potent possibilities for parasite attack

...ology, that will provide a framework to target the search for new treatments. Leishmaniasis is a devastating...researchers and in this study we have narrowed the search to a number that can be realistically studied," commented Dr Matt Berriman, senior author on the pap...

Weizmann Institute scientists develop a general 'control switch' for protein activity

...esearch and in the pharmaceutical industry, in the search for proteins that can serve as targets for new drugs. Beyond offering a potent tool that can be applied to any protein, the method has an important advantage compared with other techniques: It allows the total and precise control over the activity of...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

...iotech company to develop the technology. It would search for new drugs that interfere with key inflammatory receptors on sensory nerve cells within the CNS. Joining Kyrkanides in the publication from the University of Rochester School of Medicine and Dentistry were co-authors J. Edward Puzas, Ph.D., Don...

'Smart' mice teach scientists about learning process, brain disorders

...n are continuing. The group is also beginning a search for drugs that might create the same effects without genetic manipulation and monitoring the animals’ health and behavior over time. The findings may have applications in treating post-traumatic stress disorder, where getting a patient to learn t...

Treating HIV in war zones -- Public health emergencies need rapid advice from WHO

...e laborious process involves convening experts who search for and appraise all the relevant research literature, and who meet several times before making treatment recommendations. Such a time frame is clearly not practical in an emergency situation. Holger J. Schünemann and colleagues, authors of the r...

New research shows sharks use their noses and bodies to locate smells

...or-oozing nozzle). Plume and target preference and search time were not significantly affected by light cond...In the light, lesioning the lateral line increased search time, but did not affect success rate or plume preference. However, lesioned animals no longer discr...

Genetic roots of bipolar disorder revealed by first genome-wide study of illness

...lecular target scientists can investigate in their search for better medications for bipolar disorder," said NIH Director Elias A. Zerhouni, MD. About 5.7 million American adults have bipolar disorder, which also is called manic-depressive illness. Symptoms include extremes in mood, from pronounced over...

DOE JGI sets 'gold standard' for metagenomic data analysis

...Alignment Search Tool) is a method used to rapidly search for similar sequences in existing public databases. Mavrommatis said that a popular approach is to take the sequence, BLAST it against the database, and find the best hit and assume that the sequence queried belongs to the same group of organism...

Dinosaur hearing, listening to muscle noise, quieter cubicles

...non-invasive imaging technique using ultrasound to search for lesions in breast tissue. Generally the rival approaches to breast imaging have their weaknesses and strengths. Mammography (using x rays) has trouble detecting lesions in dense breasts often seen in young women. Conventional ultrasound can sp...

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