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Tag: "screening" at biology news

NIH creates nationwide network of molecular libraries screening centers

...aborative research network that will use high-tech screening methods to identify small molecules that can be us...inst human disease." For example, the broad-based screening effort will eventually enable researchers to explore the hundreds of thousands of proteins believed ...

New tool reveals secrets of migrating cells

...er. "To pass into the medulla they have to pass a screening test called positive selection," Witt said. "Once they do, the cells move very directly at a very fast speed inward toward the medulla, adopting a polarized shape characteristic of migrating cells." While Witt and Robey continue their two-photon ima...

Researchers identify new genes that regulate aging

...earchers have identified 23 new longevity genes by screening the genome of Caenorhabditis elegans, a small worm that is used as a model organism in genetics studies. The findings are reported in the inaugural issue of PLoS Genetics. Each of the 23 genes somehow normally acts to reduce longevity, whereas inhib...

Scientists take aim at virulent bacteria by decoding machinery of key control enzyme

...tinue their research using structure-based virtual screening techniques and high throughput equipment to screen for potential inhibitor compounds against the Dam enzyme. ...

By creating molecular bridge, scientists change function of a protein

...tural evolution in a test tube but may require the screening of an astronomical number of mutants for the creation of new protein functions. "We now provide one possible solution to a long-lasting barrier that is important in the protein engineering area -- that is the creation of the new protein functions," ...

Research on antibiotics receives historical recognition

...chatz, a graduate student of Waksman's, using soil screening methods developed by Waksman. This deliberate search for chemotherapeutic agents contrasts with the discovery of penicillin, which came through a chance observation by Alexander Fleming, who noted that a mold contaminant on a Petri dish culture had i...

Survey reveals women and doctors aren't talking about HPV

...and cervical cancer despite the fact that advanced screening is available, which can detect the virus early and...100 percent preventable through the use of regular screening with the available technologies appropriate to each age group," said Wayne Shields, president & ...

Alien woodwasp, threat to US pine trees, found in N.Y.

...hrough thousands of bark beetles caught in routine screening traps set by the New York State Cooperative Agricultural Pest Survey (CAPS) program, in search of any of 10 exotic species of bark beetles, when he stumbled across the specimen of S. noctilio . "I recognized it immediately," says Hoebeke, a taxonomi...

'Smart drug' targets deadly brain cancer

... tried it. The same research team also developed a screening technique to help predict which patients will resp...s that determines drug activity could be useful in screening patients to help determine the best candidates for the drug. Says Dr. Galanis, "This could allow us ...

Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells

...provide a strong argument for mandatory, universal screening of all newborns for the genetic lysosomal storage diseases. The major barrier to universal newborn screening is building an infrastructure to support widespread testing, she said. The cost of testing itself wo...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...spital and colleagues used a comprehensive genetic screening technique to search for genes that are differentially expressed in ALL cells that demonstrated cross-resistance to two or more commonly used chemotherapeutic agents. The researchers identified several genes that were differentially expressed in ALL ...

Study reveals dramatic difference between breast cancers in US and Africa

...er 50 have less risk than Caucasians. Most of the screening guidelines in this country are based on studies that primarily looked at Caucasians, said Olopade. "We need to reconsider how to screen for a disease that is less common but starts sooner and moves faster. Obviously an annual mammogram beginning at 5...

Biomarkers isolated from saliva successfully predict oral and breast cancer

...g been a goal of scientists seeking quick and easy screening tools that could be done in a doctor's office. The search for such tests, however, has been stalled until recently with the advance of several emerging technologies including improved methods to identify, collect, preserve and amplify genetic materia...

New understanding of DNA repair may pave way to cancer treatments

...th in mouse models. Ongoing studies are devoted to screening for compounds that mimic the peptide's actions and to allow for further development of the peptide toward clinical assessment. "Until our recent studies, we were certain that the mechanism by which ATF2 affects melanoma growth was primarily through ...

Bioelectronic ‘signatures?hold key to DNA mutations

... small, portable, electronic devices for the rapid screening and identification of genes that harbor disease. Joseph Wang, director of the Center for Bioelectronics and Biosensors at the Biodesign Institute at ASU, led a team effort that successfully merged work in the fields of biosensors, electronics, and n...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

...provide a strong argument for mandatory, universal screening of all newborns for the genetic lysosomal storage diseases. The major barrier to universal newborn screening is building an infrastructure to support widespread testing, she said. The cost of testing itself wo...

To control germs, scientists deploy tiny agents provocateurs

...l chemistry techniques, Blackwell and her team are screening through hundreds of molecules at a time. The researchers have so far unveiled three promising organic compounds that seemingly quell bacterial signaling. ...

Scientists identify molecule that regulates well-known tumor suppressor

...niversity of Toronto and colleagues used a genetic screening method in fruit flies and identified the molecule DJ-1 as a PTEN suppressor. In studies with mammalian cells, low levels of DJ-1 correlated with decreased PKB/Akt activity, while increased DJ-1 led to activation of PKB/Akt and enhanced cell survival...

Promising new West Nile therapy cures disease in mice

...s effective ones through a tedious molecular-level screening process. They then turned to Rockville, MD-based MacroGenics Inc., to create a human-like version of the most effective antibody. MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody. T...

New insight into regulation of blood stem cells

...oblem. The researchers used random mutagenesis and screening to find animals with hematopoiesis defects, and they used genetics to identify the causative gene. One line mapped to a mutation in the gene c-Myb, which has a known role in regulation of blood formation. Interestingly, they found that c-Myb is not ...

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