screen 2 4

Tag: "screen" at biology news

Genetically altered mice no longer like cocaine

... high in normal mice. Gu said the next step is to screen for compounds that could produce the same effect that the genetic modifications did in this study. "We hope to find certain drugs that prevent cocaine from binding to transporters, but that still allow the transporter protein to carry the dopamine b...

Study fishes out new role for prostaglandins

... "If you could use the zebrafish intelligently to screen for these drugs, it might really speed up the drug discovery process and give us some early clues about the effects we may see in humans," DuBois said. ...

New method for identifying microbes

...ow and error prone as the culture conditions often screen out important members of the community. Sequencing entire genomes, while highly specific and informative, would be too labor intensive and costly. So scientists have been searching for ways to identify key segments of genetic code that are short enou...

Study finds 60 new genes controlled by DNA snippet

...such studies use high-powered computer programs to screen data. In this case, researchers used a high-speed ... that the segment has a valuable function. Miano's screen required that CArG boxes shared by humans and mice be included in his expanded version of the CarGom...

One fish, two fish: New MIT sensor improves fish counts

...fference between seeing everything on a television screen and seeing only one pixel. The new sensor system, described in the Feb. 3 issue of Science, could allow government agencies to figure out what's really happening to fish populations, which many environmentalists and scientists believe are in rapid ...

Gene variation increases SIDS risk in African Americans

... this may one day allow us to intervene. We might screen to identify children at high risk and teach parents how to lessen the likelihood of secondary challenges. We have already begun to evaluate drugs that may mitigate the risk." SIDS -- the sudden and unanticipated death of an infant with no detectabl...

Report lists top 20 most-vulnerable African carnivores

...d. "Instead of an active site inhibitor, you could screen for a TEN domain inhibitor." ...

Groovy protein essential for promoting cancer development

...d. "Instead of an active site inhibitor, you could screen for a TEN domain inhibitor." ...

Dogs keep dying: Many owners unaware of toxic dog food

...e dogs food containing a lethal toxin. To better screen affected dogs so they can be treated as soon as possible, Cornell veterinarians report that they now have a new test, adapted from one used in humans, to accurately assess aflatoxin poisoning in dogs ( see companion story ). Currently, about two-thir...

A clue from macaques yields evidence for impaired retroviral defense genes in humans

...ion. This prompted the Malik and Emerman groups to screen human populations for slightly altered versions of TRIM5 that might be able to resist HIV infection. Unexpectedly, the researchers found a single mutation in TRIM5 that impairs its ability to defend against retroviruses. This mutation occurs at a v...

Novel method reveals how menthol discovery could point towards new or improved pain therapies

...ethods." Because the methodology can be used to screen for activation or inhibition, Bandell added, it could prove to be useful as a general method to analyze the mechanism by which drugs can activate or inhibit ion channels or other receptors. Specifically, the new methodology could be used to identify ...

New test to detect rare proteins in blood

...hnology will soon be robotized so as to be able to screen for many rare disease-causing proteins using tiny ...unts of blood. "It is even possible that one could screen for multiple diseases at the same time and produce a precise accounting of whether disease-causing m...

Losing sleep undoes the rejuvenating effects new learning has on the brain

...ed certain types of brain lesions may be unable to screen out irrelevant stimuli such as random noises in a ...p restriction causes people to lose the ability to screen out extraneous stimuli and preferentially apply attention switching, she said. ...

Removing DNA repair gene causes metabolic syndrome

...rome with the goal of someday developing a genetic screen for the disease. He also wants to examine ways to delay the onset of symptoms, such as increasing the expression of the NEIL1 gene or dampening oxidative stress to the cells that damages their DNA. Such techniques could one day become therapies. "On...

Georgia Tech accelerates drug discovery with new IBM supercomputing cluster

...lopers to reduce the number of compounds they must screen by a factor of 10." The 1000-node Cluster 1350 system built on IBM BladeCenter® systems and powered by dual-core AMD Opteron TM processors is capable of performing more than 8.5 trillion calculations per second, which would place it as the world's ...

Genomics-based vaccine could prevent deadly cattle disease

...lection strategy, ILRI also incorporated a random screen of T. parva DNA for vaccine candidates. In total, the team found five candidate vaccine antigens. In lab tests, these antigens triggered a response from cattle immune killer T cells. Going a further step further, the scientists inoculated cattle w...

Hantavirus found in African wood mouse

...laboratory. "Other researchers will probably now screen their rodent biopsy collections for similar African hantaviruses based on the sequence information of the Sangassou virus," said ter Meulen. In addition to ter Meulen, authors of the article detailing the discovery include Boris Klempa, Detlev Kruge...

Forsyth scientists gain greater understanding of how embryos differentiate left from right

...flow of hydrogen ion or H+ flux. A pharmacological screen implicated the H+-pump H+-V-ATPase in Xenopus (frog) embryo asymmetry, where it directs left- and right-sided gene expression. The cell cytoskeleton is responsible for the LR-asymmetric localization of this pump during the first few cell cleavages in...

Study in Science holds promise for a new approach to drug therapy

...of the hotspot before they could apply software to screen through databases of "drug-like molecules" to identify those that fit into, and bound tightly to, specific parts of the hotspot. These "drug-like" molecules could then be used to make precision changes in the hotspot's behavior. Any new drug would ne...

Waking a sleeping virus

... would have to look like. The next step will be to screen likely molecules in hopes of finding an inhibitor. "We have been trying to develop an effective way to treat EBV infections for over 20 years, without major successes," Morand says. "Thanks to this partnership between medical research and structural ...

1 2 3 4 5 6 7