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Tag: "scaffold" at biology news

When the going gets tough, slime molds start synthesizing

...hat one of them, called Steely2, made the chemical scaffold of DIF-1 in a test tube. All that was left was to prove was that slime molds themselves used the newly discovered enzyme to make DIF-1. For that Noel and Austin turned to co-senior author Robert Kay, Ph.D., a Dictyostelium cellular differentiation ...

'LEGO-Like' building blocks to halt cell growth wins Hebrew University prize

...tric-like structures called "scaffolding." Each scaffold is specifically designed to combine the peptides i...that with a particular combination of peptides and scaffold design, it is possible to create a synthetic molecule that will bind to the IGF-1 (insulin-like grow...

Ghost protein leaves fresh tracks in the cell

...vered in red blood cells, where it forms a protein scaffold under the cell's membrane. It was named for its ability to maintain the shape of cell "ghosts," which have been emptied of their contents. Ankyrin serves as the mortar that attaches spectrin to the red blood cell membrane. Dubreuil and his UIC co-w...

Finding the right mix: A biomaterial blend library

... investigation. Such materials provide a temporary scaffold for cells to grow and tissue to regenerate. In a 2006 study* presented at the national meeting of the American Chemical Society in September, the researchers analyzed how two types of model cells--immune cells known as macrophages and bone cells know...

Immune cell communication key to hunting viruses, Jefferson immunologists show

...cles called quantum dots. These served as a unique scaffold to carry presenting proteins (called Major Histocompatibility Complex (MHC) proteins) and the attached virus portion, mimicking the clustering of MHC proteins on the surface of target cells. The researchers were able to place many MHC complexes, both...

Fat stem cells being studied as option for breast reconstruction

...erived stem cells that are seeded onto microscopic scaffold structures will enable the production of a durable, replacement soft tissue. The team, led by J. Peter Rubin, M.D., assistant professor of plastic and reconstructive surgery at the University of Pittsburgh School of Medicine, recently received a thre...

MIT creates 3-D scaffold for growing stem cells

...tiated into brain cells on a new three-dimensional scaffold of tiny protein fragments designed to be more like...brizio Gelain from Milan, Zhang created a designer scaffold from a network of protein nanofibers, each 5,000 times thinner than a human hair and containing pore...

Does natural selection drive the evolution of cancer?

...to stimulate the growth of the cells that form the scaffold in which the tumor cells grow, known as fibroblasts. The fibroblasts, in turn, send signals to the tumor cells to stimulate their growth. Recent studies suggest, too, that the fibroblasts in a tumor microenvironment begin to acquire mutations of thei...

'Tribbles' protein implicated in common and aggressive form of leukemia

... several groups shows that Tribbles functions as a scaffold to bring together a complex that mediates protein degradation. Protein degradation is required for normal cellular function; however, data from the Pear lab suggests that mistakes in the expression of the Tribbles gene may lead to degradation of prot...

MIT bioengineer advances survival, promise of adult stem cells

...xposure on the cell surface. "Putting them on a scaffold is appealing because then you can control the concentration and location and so forth," Griffith said. The ceramic and polymer scaffold, which remains in the patient's body during healing but then resorbs, also provides structure for the stem cells a...

Tissue engineering for craniofacial reconstruction

...biomaterial scaffold. It is widely recognized that scaffold architecture can profoundly influence the behavior...olymerization, which affords tremendous control of scaffold morphology. HIPEs can be readily molded into the irregular shapes often required in craniofacial rec...

Natural polyester makes new sutures stronger, safer

...ely, the researchers hope to develop an artificial scaffold that could be used to grow heart valves after bein... "We've been able to show we can produce a valve scaffold that functions better and can grow with the animal," Williams said. "If the valve can grow with the ...

Woven scaffolds could improve cartilage repair

...ells. "If further experiments are successful, the scaffold could be used in clinical trials within three or f...tive cartilage. In laboratory tests, the fabric scaffold that the researchers have created had the same mechanical properties as native cartilage. In the nea...

Tissue engineered scaffolding allows reproduction of cartilage tissue

...e. Cartilage cells are extracted and seeded to the scaffold which is implanted into the body, where new cartil...tivation and post-procedure. "The cell-derived scaffold could provide a favorable environment for cartilage cells to maintain their characteristics while sy...

University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

...a biodegradable porous, tubular polyester urethane scaffold using a rotational vacuum seeding device. After culturing their vascular constructs for seven days, the investigators then implanted them in the abdominal aortas of rats eight weeks before performing tests to determine how well the grafts had per...

Now, self-healing materials can mimic human skin, healing again and again

...ing materials, the researchers begin by building a scaffold using a robotic deposition process called direct-w...-dimensional structure, layer by layer. Once the scaffold has been produced, it is surrounded with an epoxy resin. After curing, the resin is heated and the i...

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