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Tag: "scaffold" at biology news

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

...ures,known as 'tissue scaffolds'. The shape of the scaffold determines theshape of the tissue as it grows. The structures are created by printingvery thin layers of a material repeatedly on top of each other untilthe structure is built. Each layer is just 10 microns thick (1,000layers equals 1cm in thickness)...

U-M scientist to talk about tissue engineering at AAAS

...amaged too badly to simply heal on its own. A tiny scaffold helps direct the engineered cells to the right place, then dissolves once the cells begin to generate to fill in the wound. "In certain kinds of defects, the body cannot heal itself and the body needs a jumpstart," Krebsbach said. To heal a large wo...

Promising new West Nile therapy cures disease in mice

...ntibody that cripples the West Nile virus into the scaffold of a human antibody. The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection. ...

Protein helps regulate the genes of embryonic stem cells

...roteins that group together to provide a molecular scaffold supporting the roughly 35,000 genes in the nucleus of every human cell. Histone modifications affect gene activity and include methylation, in which a methyl component is attached to the histone protein. The prevailing model is that methylation on h...

Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs

... in slow synaptic transmission here by acting as a scaffold for signaling molecules in response to dopamine receptor activation," Caron said. "The observations also provide an alternative pathway by which dopamine receptor activation leads to the expression of dopamine-associated behaviors." The findings re...

Modified collagen could yield important medical applications

...omotes blood clotting and provides the sponge-like scaffold upon which cells build nerves, bones and skin. Because it is non-toxic, dissolves naturally over time and rarely triggers rejection, collagen is commonly used in cosmetics, drug delivery systems and biocompatible coatings. Yu's goal is to change so...

Unusual antibiotics show promise against deadly 'superbugs'

...omotes blood clotting and provides the sponge-like scaffold upon which cells build nerves, bones and skin. Because it is non-toxic, dissolves naturally over time and rarely triggers rejection, collagen is commonly used in cosmetics, drug delivery systems and biocompatible coatings. Yu's goal is to change so...

Anthrax inhibitors identified by Burnham team

...laboratory, the scientists were able to identify a scaffold that served as a template for designing a preferred structure for small-molecule inhibitors of LF. Lead compounds were synthesized and validated as highly potent and selective against LF in vitro. In in vitro assays, the compounds did not affect prot...

New complete muscle grown in the lab

...y seeding a sponge-like, three-dimensional plastic scaffold with myoblasts and endothelial cells, which are the precursors to mature skeletal muscle and blood vessel cells. The researchers also added connective tissue cells called fibroblasts to the mix as a crucial third ingredient. "The idea is that this h...

Scientists discover stem cell origin of neck and shoulders

...bellished and filled by other cells: just like the scaffold of a house which is later filled in by bricks, mortar and windows. If cells are from the same stem cell origin they 'stick together' throughout their life ?normally without us noticing it." As the joining points between muscles and bones have surviv...

New research could help us deliver genes for new bone formation

...g around the nanoscopic gene delivery systems. The scaffold controls the release of the gene delivery systems ... of bone tissue. The research teams are using the scaffold technology to develop therapeutic applications. They are investigating the most efficient and effect...

Nanotubes inspire new technique for healing broken bones

...the first time that carbon nanotubes make an ideal scaffold for the growth of bone tissue. The new technique c...cess of a bone graft depends on the ability of the scaffold to assist the natural healing process. Artificial bone scaffolds have been made from a wide variety ...

Scientists use stem cells to grow cartilage

...e cells were then implanted in mice on a bioactive scaffold for 35 days. When they removed the scaffold, the c...e. The team had previously developed the bioactive scaffold which was used as a scaffold to grow the stem cells on. Dr Anne Bishop, from Imperial College Londo...

Bioengineers create stable networks of blood vessels

...ts or drugs, and waste," said Lavik. "The hydrogel scaffold materials are generally highly biocompatible and safe to implant due to the presence of large volumes of water." ...

Novel molecular 'signature' marks DNA of embryonic stem cells

...rmal biology and disease." Chromatin–the protein scaffold that surrounds DNA ?acts not only as a support for...n as "epigenetic" information. Thus, the chromatin scaffold (including its bivalent domains) forms a sort of molecular memory that, along with DNA, can be trans...

Formation of cellulose fibers tracked for the first time

...said. "The microtubules act as more than a general scaffold for organizing the cell wall; individual elements of the microtubule array appear to actively direct the pattern of the cellulose fibers. This work should set a long-standing discussion to rest." ...

Bioactive cement scaffold may improve bone grafts

...a method for making scaffolds for bone tissue. The scaffold is seeded with a patient's own cells and is formed...olve when exposed to the body's fluids, creating a scaffold that is filled by the now released bone cells. The cement, a calcium phosphate material, is strengt...

Scientists make first step towards 'holy grail' of crystallography

... developed by Imperial's material scientists, as a scaffold to trap and encourage the growth of protein crystals. BioGlass is a porous material, with a variety of different size pores able to trap different size proteins. They found BioGlass induced the crystallisation of the largest number of proteins ever...

Manchester scientists create new bio-gel for 3D cell culture

... damaged tissue. Like the ECM, the gel acts like a scaffold in which cells can grow. In their paper, 'Nanostructured Hydrogels for Three-Dimensional Cell Culture Through Self-Assembly of Fluorenylmethoxycarbonyl-Dipeptides', Dr Rein Ulijn and collaborators describe how the gel is created through a process of...

Microscopic scaffolding offers a 'simple' solution to treating skin injuries

A revolutionary dissolvable scaffold for growing new areas of skin could provide a safe...ally grow over it. When placed over the wound, the scaffold dissolves harmlessly over 6 to 8 weeks, leaving the patient's skin cells behind. This new approac...

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