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Common treatment for methamphetamine overdose may damage brain cells

...tions would affect methamphetamine toxicity in the same model." The rats in the experiment were injected with either methamphetamine or a saline solution over a period of eight hours. When the rats were given haloperidol before and nearly halfway through the eight-hour period, Yamamoto and his colleagu...

For many insects, winter survival is in the genes

... run a high fever. "But insects make these very same stress proteins during times of low temperature as well as during exposure to high levels of toxic chemicals, dehydration and even desiccation," Denlinger said. He and his colleagues first figured out how many genes were turned on only during the ...

Detecting cold, feeling pain: Study reveals why menthol feels fresh

...ensation of burning pain through activation of the same receptor on sensory neurons. Most recently, they identified the receptor of isothiocyanate compounds, which constitute the pungent ingredients in such plants as wasabi and yellow mustard. In response to high temperatures, the receptor produces pa...

Better insight into brain anatomical structures

...ighted by the antibody-coupled contrast agent. The same principle should allow other disease-related changes or physiological systems to be visualized by using the appropriate antibodies....

'Virtual Patient' to simulate real-time organ motions for radiation therapy

...ents with respiratory and cardiac diseases. At the same time, Xu will continue to work on the 3-D VIP-Man to create a "family" of virtual patients, ranging in ages and sizes, in collaboration with researchers worldwide through the Consortium of Computational Human Phantoms ( http://www.virtualphantoms.org...

Human stem cell treatment restores motor function in paralyzed rats

...ffective treatment for patients suffering from the same kind of ischemia-induced paralysis.” Marsala is currently testing the human stem cell therapy for safety and efficacy in other animal models, and hopes to move to clinical trials in humans by next year. Paraplegia from spinal cord ischemia is a s...

Hawaiian treasure, macadamia nuts good for the heart

... in cookies and muffins. "The total fat was the same in both diets," says Griel. "We substituted the macadamia nuts for other sources of fat and protein in the diet. For example, we could switch skim milk for 2 percent milk and add some macadamia nuts." Macadamia nuts are native to Australia, but we...

HIVMA opposes The Gambia's unproven AIDS remedy

...t Jammeh is giving people false hope, while at the same time making them stop treatment that has been demonstrated to save lives." "Any treatment that claims to alleviate this devastating disease must be subjected to rigorous scientific scrutiny," he added. "A growing body of evidence from Africa shows...

Arctic ice retreating more quickly than computer models project

...ate, both observations and the models point in the same direction: the Arctic is losing ice at an increasingly rapid pace and the impact of greenhouse gases is growing," says NCAR scientist Marika Holland, one of the study’s co-authors. The authors compared model simulations of past climate with observ...

Catching cancer's spread by watching hemoglobin

...bin absorbs light from both of these lasers at the same time, in a process known as "two-photon absorption," and then gives off signals that can be detected to build up an image. One "pump" laser boosts (excites) hemoglobin molecules to a higher energy state. The other "probe" laser monitors the hemoglobi...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

...enzyme. And as Montminy adds, "Application of this same pathway over and over across species further emphasizes its importance."...

A cherry on top: Tart cherries may alter heart/diabetes factors

...ose of the rats that did not receive cherries. The same was true for those on the 10-percent cherry diet, compared with rats that received a diet with an equivalently high level of carbohydrates not from cherries. The researchers also measured plasma TEAC, a measure of antioxidant capacity in the bloo...

Scripps research team sheds light on long-sought cold sensation gene

... of the analgesic effects of cold. Just how the same sensation can be interpreted as unpleasant under c...ng to find out how the brain takes essentially the same signal and, depending on context, interprets it differently,?says Dhaka. ...

Technique monitors thousands of molecules simultaneously

...ological behavior of up to 12,000 molecules at the same time. The work is motivated by a desire to map the three-dimensional requirements of biological receptors on cell surfaces. Typically, receptors bind small molecules through a lock and key mechanism where the molecule is the key and the receptor the...

'Insulator' helps silence genes in dormant herpes virus

...s revealed that the viral DNA binds to CTCF in the same manner as the host DNA binds to the protein. "By binding in this manner, we believed the CTCF protein was interacting with other viral proteins to form a type of insulator in the virus structure," Zhou says. To verify that it was an insulator...

Gene malfunctions cause schizophrenia, depression symptoms in mice

.... Both types of DISC1 mutant mice exhibited the same kind of reduced brain volume seen in people with schizophrenia and depression, the researchers found. Also, both types showed biochemical abnormalities in the function of the protein produced by the DISC1 gene. The researchers concluded that the d...

pHLIP, a novel technology to locate and treat tumors

...-helix predominates. An earlier paper from the same groups shows that at low pH, pHLIP can move cell-impermeable molecules across a cell membrane, where they are released in the cytoplasm. “pHLIP acts as a molecular nanosyringe, inserting itself into the cell membrane and injecting compounds into cell...

Why do oysters choose to live where they could be eaten?

...cted to settle on oyster reefs among adults of the same species because of the potential benefits to group...iving, (2) if adult oysters will eat larvae of the same species, and (3) how risky is gregarious settlement among cannibals. Using a series of laborator...

Anthrax paralyzes immune cells with lethal toxin, UF research shows

...at's controlling it. But Listeria seems to use the same pathways that a cell uses to crawl. So anything that blocks Listeria we predict would also block neutrophils from crawling. And that's what we found."...

New knowledge improves rice quality

...e world’s millions of poor rice farmers and at the same time provide consumers with more nutritious, better tasting food. New scientific knowledge is allowing rice researchers to develop better quality rice varieties that could fetch a higher price from consumers, especially increasingly affluent rice co...

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