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Tag: "roles" at biology news

St. Jude projects 90 percent cure rate for ALL

...gs. Such studies often include the analysis of the roles of hundreds or even thousands of genes. Another significant contribution made by St. Jude researchers is the measurement of minimal residual disease (MRD)--the small populations of leukemic cells that survive initial treatment (induction therapy). T...

Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

...ecific kinds of cells or tissues. It may also play roles in maintaining cells, rearranging genomes and laying down the architecture of the brain, for example. In the lab, Dicer is used in mice to switch off any combination of genes -- either in targeted or in random fashion -- to infer a gene's function, ...

Molecule does more than slice and dice RNA

...ecific kinds of cells or tissues. It may also play roles in maintaining cells, rearranging genomes and laying down the architecture of the brain, for example. In the lab, Dicer is used in mice to switch off any combination of genes -- either in targeted or in random fashion -- to infer a gene's function, ...

Forsyth scientists gain greater understanding of how embryos differentiate left from right

...n humans. This fascinating ion pump has additional roles during development that are a goldmine of novel ce...ons of the normal LR pattern, suggesting important roles for both physiological parameters. V-ATPase inhibition also abolished the normal localization of ser...

Cholesterol gets 'thumbs up' for role in digit development

...red in the early 1990s and shown to have important roles in patterning the developing embryo, including proper digit patterning. Chiang led the early studies showing that mice without Sonic hedgehog developed only a single digit â? a thumb on the front paw (or a "big toe"on the back paw). The Sonic hed...

Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin

...ynthesis. Pectic polymers appear to have multiple roles in growth, development and disease resistance, and the new tools will open new areas of inquiry for researchers. "We could, for instance, modify a pectic structure to get a specific biological effect," said Mohnen. "The ability to modify pectin syn...

Warming trend may contribute to malaria's rise

...e constructive one about interactions and relative roles of all the factors that may be contributing to the resurgence of malaria." ...

Driver of anthrax toxicity could lead to late-stage therapy

... effort to identify host genes that have important roles in infection, with the hope of finding possible ne..." for LRP6, a gene earlier found to play important roles in pathways underlying early development and cell proliferation, the researchers said. The discovery...

Marijuana-like compounds suppress the immune response

... an early stage. Among the possible immunological roles for CB2 is an involvement in the initiation of white blood cell migration to sites of infection and inflammation. In the Journal of Biological Chemistry study, which was featured as a "Paper of the Week", Yumi Tohyama and colleagues used an in vit...

Hyena mothers give their cubs a helpful dose of hormones

...in both sexes. In hyena packs, male-female social roles are reversed from what is normally found in nature--that is, female hyenas are larger, more aggressive and dominate the group. They even have deceptively male-like genitalia, leading to the misconception that they are hermaphrodites. According to Je...

Powerful new tool for studying brain development

... the expression of hundreds of genes that play key roles directing brain development, controlling the expression of other genes, guiding protein production and transporting molecules within the cell. A key part of the BGEM's success was the development at St. Jude of bioinformatics software that routinel...

Largest study of human 'interactome' reveals a novel way

...y that could mislead researchers investigating the roles of specific proteins in the cell." Pandey is the chief scientific advisor to the IOB and senior author of the Nature Genetics article. The team's conceptual advance was made by comparing human data with 6,014 genes in yeast and 2,284 genes in mice ...

Common molecular 'signature' identified in solid tumors

...ants to mice to humans ?confirming their important roles in growth and survival. Carlo Croce, professor and chair of molecular virology, immunology and medical genetics at The Ohio State University and the first researcher to discover miRNA involvement in human cancer, had a hunch that there might be sha...

Infant transplant patients resist infections that kill adult AIDS patients

...tes of Health to support further research into the roles of T cells, B cells and antibody production in the outcomes of pediatric heart transplants. "We're very excited about this opportunity to expand the current understanding of the human immune system -- and hopefully, in the process, discover new treat...

Open Source Biotechnology alliance for international agriculture

...ing powerhouses of innovation, poised to play lead roles in the next generation of biological problem solving. The Patent Lens will also develop analyses and foster the capacity in the developing world to create patent maps of the key emerging technologies that could be constrained by complex intellectual...

Understanding the oceans microbes is key to the Earth's future

...planet, the biogeography of these organisms, their roles in symbiotic relationships and pathogenesis, their...ture research in marine microbiology including the roles of both climate change and human activities on the populations and processes of marine microbes. Th...

Scientists show how thinking can harm brain cells

...compound that promotes inflammation and plays many roles in the brain. It can be produced by neurons and takes part in the working of synapses, including activity associated with learning and remembering. It also is produced by immune cells during inflammation. The amount of PAF in the brain increases dram...

Technique offers new view of dynamic biological landscape

...ssign new functions to known genes, to uncover the roles of previously uncharacterized proteins, and to def...tion to offering important basic insights into the roles of proteins and genes, E-MAPs will also contribute to understanding evolutionary processes. "In evol...

Scientist uses form to explain function of key building blocks of life

...t an undergraduate and graduate student played key roles in the study. Lin, who plans to complete her Ph.D. this spring, spent years tackling what Markley described as a "complex and difficult project." Erika Gebel, the undergraduate on the study, is now pursuing a graduate degree of her own, a pursuit t...

Algal protein in worm neurons allows remote control of behavior by light

...ther. Such so-called channel proteins play central roles in the activities of neurons and muscle cells, and while some channel proteins are sensitive to chemicals or electrical signals, ChR2 and its relatives are controlled directly by certain wavelengths of light, making them ideal for remote control in t...

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