Navigation Links

Tag: "rna" at biology news

A new mechanism of regulating RNA degradation

.. As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

UCLA investigators reviewed pharmaceutical ads in American medical journals and found that nearly one-third contained no references for medical claims; while the majority of references to published material was available, only a minority of company data-on-file documents were provided upon request; and the majority of original research cited in the ads was funded by or had authors affiliated with...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

When the most common adult leukemia in the United States was last reviewed by the New England Journal of Medicine (NEJM) in 1995, it was seen through the eyes of theories that dated back to the 1960s. As such, the journal recently invited three of the world's foremost experts on chronic lymphocytic leukemia (CLL) to write an authoritative update covering the transformation in the scientific commu...

Study finds more than one-third of human genome regulated by RNA

For many years, DNA and proteins have been.viewed as the real movers and shakers in genomic studies, with RNA seen.as little more than a messenger that shuttles information between the.two. But researchers from Whitehead Institute for Biomedical Research.and Massachusetts Institute of Technology have discovered that small.RNA molecules called microRNAs regulate thousands of human genes--more.than...

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

Alan List, M.D., leader of the Hematologic Malignancies Program at the H. Lee Moffitt Cancer Center & Research Institute, recently conducted a phase I/II trial of the experimental drug Revlimid showing promise as an innovative way to treat patients with myelodysplastic syndrome (MDS), a form of pre-leukemia. Given in pill form, Revlimid simultaneously blocks the growth of new blood vessels th...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

Research in the laboratory of Assistant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in March issues of the journals Cell and Developmental Cell. . The oncogene Ras is out of control in about 20 percent of cancers where it is over-expressed or ac...

Scientists identify genetic pathways essential to RNA interference

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the jou...

International trial of two microbicides begins

A large, multisite trial designed to examine the safety and preliminary effectiveness of two candidate topical microbicides to prevent HIV infection has opened to volunteer enrollment. The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, represents a partnership among various research institutions in Africa and the U...

New RNA polymerase discovered in plants

Biologists at Washington University in St. Louis have discovered an entirely new cellular "machine" in plants that plays a significant role in plant flowering and DNA methylation, a key chemical process essential for an organism's development. .. .. RNA polymerase is an enzyme, or protein machine, essential for carrying out functions o...

RNA project to create language for scientists worldwide

Research into ribonucleic acids (RNA)--the building blocks of life--is exploding as scientists worldwide discover the roles of RNA in genetics, health, disease and the development of organisms. The rapidly growing body of knowledge has created the need for researchers to develop a shared vocabulary and system for describing, cataloging and comparing their findings. . .. "The consortium will devel...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

First-of-its-kind analysis published in the Feb. 8 PNAS supports the concept of a basic wiring diagram for all eukaryotes. .. Researchers in California, Israel, and Germany have compared three distantly related species ?baker's yeast, a worm, and the fruit fly ?and reported that protein "wiring" connections in one species are often conserved in all three. This first-of-its-kind analysis of three...

International HapMap consortium expands mapping effort

The International HapMap Consortium, boosted by an additional $3.3 million in public-private support, today announced plans to create an even more powerful map of human genetic variation than originally envisioned. The map will accelerate the discovery of genes related to common diseases, such as asthma, cancer, diabetes and heart disease. .. When the project was launched in October 2002, the con...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

New insights by Duke University Medical Center researchers as to how HIV evades the human immune system may offer a new approach for developing HIV vaccines. The findings suggest some HIV vaccines may have failed because they induce a class of antibodies that a patient's own immune system is programmed to destroy. .. The Duke team discovered that certain broadly protective antibodies, which recog...

Products containing specific probes for detecting alternative splice forms protected

ExonHit Therapeutics, today announced the grant of a major patent, US # 6,881,571, by the United States Patent and Trademark Office on microarray products allowing the specific detection of mRNAs produced by alternative splicing, covering microarrays optimised for the discovery of alternative RNA splicing events. The patent protects the probe configuration of a unique set of five oligonucleotides...

Researchers rein in regulatory RNAs

A team of scientists led by Dr. Kuniya Abe from the RIKEN BioResource Center in Japan has performed one of the most comprehensive genome-wide experimental analyses of sense-antisense transcripts to date. Their findings are published in the April issue of the journal Genome Research. . Sense-antisense transcripts, or SATs, are pairs of RNA molecules generated from opposite DNA strands at the same...

Buying Time Through Hibernation on Demand

Scientists at Fred Hutchinson Cancer Research Center have, for the first time, induced a state of reversible metabolic hibernation in mice. This achievement, the first demonstration of "hibernation on demand" in a mammal, ultimately could lead to new ways to treat cancer and prevent injury and death from insufficient blood supply to organs and tissues. . "We are, in essence, temporarily convertin...

miRNA profiling

To be published in the June 1 issue of G&D, Dr. Thomas Tuschl and colleagues describe the most comprehensive profile to date of microRNA (miRNA) expression during zebrafish development. The authors cloned 154 distinct miRNAs (10 of which are completely novel) in a developmental and tissue-specific manner. . They also identified ?for the first time ever in a vertebrate ?a new class of small RN...

Solutions that reduce death of marine life reeled in by International Smart Gear Competition

As the world prepared to observe Earth Day, World Wildlife Fund and its partners in the International Smart Gear Competition announced three new winning solutions to prevent the accidental maiming and killing of marine mammals, juvenile fish, and sea turtles that become ensnared by fishing nets and longlines--a problem known as bycatch--while also improving the efficiency of commercial fishing. ....

Silence the gene, save the cell: RNA interference as promising therapy for ALS

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease. Their results will be published in the April issue of Nature Medicine, and in the...

Scientists identify genetic pathways essential to RNA interference

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the jou...

Canadian youth 4th highest in international obesity study

Canadian youth rank fourth-highest on the obesity scale in a new international study of adolescents from 34 countries, says co-author Dr. Ian Janssen, a professor in Queen's University's School of Physical & Health Education and Department of Community Health & Epidemiology. . .. Along with this alarming finding is one that runs contrary to what the research team expected. Surprisingly, a...

Used in a new way, RNA interference permanently silences key breast cancer gene

In laboratory mouse experiments, researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human breast tumors, thus reducing the cancer's ability to become invasive. . The study, presented at the a...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

A group of scientists at The Scripps Research Institute is reporting a discovery that sheds light on an area of research fundamental to everything from the normal processes that govern the everyday life of human cells to the aberrant mechanisms that underlie many diseases, including cancer and septic shock. .. .. All genes expressed in the human body must be transcribed as mRNA before they can be...

NYU, Rockefeller researchers find complexity of regulation by microRNA genes

Collaborating researchers at New York University and Rockefeller University have discovered that microRNA genes, which have recently been shown to have key roles in gene regulation, can team up and regulate target genes in mammals. MicroRNAs are a recently discovered large class of regulatory, non-coding genes, which bind to partially complementary sites in target messenger RNA to regulate their...

Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs

Duke University Medical Center researchers have discovered a new mechanism by which chronically high levels of the neurotransmitter dopamine exert their effects on the brain. Normally associated with triggering feelings of pleasure, excess concentrations of dopamine underlie schizophrenia, attention deficit hyperactivity disorder and other psychiatric conditions. The findings therefore provide ne...

Open Access journals get impressive impact factors

Impressive impact factors prove that BioMed Central's Open Access journals are high quality and widely read and cited. Journals published by BioMed Central have again received impact factors that compare well with equivalent subscription titles, it was announced today, with five titles in the top five of their specialty. The high impact factors for these journals affirm that they are respected by...

MicroRNAs play a big part in gene regulation - and evolution

Regulating when and where certain proteins are made is crucial to the normal functioning of living things. To make proteins, information from DNA is transcribed into RNA molecules and then translated into the amino acids building blocks of proteins. But not all genes code for proteins--some make RNA molecules called microRNAs. These small RNA molecules interfere with--and therefore control--the p...

Molecular steps involved in the creation of gene-silencing microRNAs identified

First discovered only a few brief years ago, microRNAs are small, remarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for translating genes into proteins. . But how do miRNA...

International Team Determines Geographic Origin of Leprosy

Leprosy likely originated in East Africa and spread to Asia and Europe before being imported into West Africa by explorers, report scientists in this week's issue of Science. The findings enrich the historical understanding of leprosy's global migration and contradict a commonly held view that leprosy spread to West Africa directly from East Africa, say the researchers. . The international team o...

Scientists find microRNAs regulate plant development

The plant hormone indole-3-acetic acid (IAA), commonly referred to as auxin, plays a major role in regulating plant growth and development. Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to d...

Drug Offers Alternative to Surgical Treatment After Miscarriage

A drug first used to reduce the risk of stomach ulcers in people taking certain types of painkillers offers an alternative to surgery after miscarriage, according to a study by researchers at the National Institute of Child Health and Human Development of the National Institutes of Health and other research institutions. .. . The drug, misoprostol, has been used to reduce the risk of stomach ulce...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

University of Utah researchers-feeding microscopic pills of RNA to quarter-inch long worms called planarians-have identified many genes essential to understanding a biological mystery that has captivated scientists for hundreds of years: regeneration. .. . The study, to be published in the May issue of Developmental Cell, employed the first lar...

New study expands understanding of the role of RNA editing in gene control

For many years, scientists thought gene activity was relatively straightforward: Genes were transcribed into messenger RNA, which was processed and translated into the proteins of the body. Certainly, there were many factors governing the transcription process, but gene control happened at the level of the DNA. . In the past few years, however, evidence for a more nuanced understanding of the tot...

Rehydrate -- your RNA needs it

Water, that molecule-of-all-trades, is famous for its roles in shaping the Earth, sustaining living creatures and serving as a universal solvent. . .. .. RNA enzymes, also known as ribo...

Funding and bureaucracy, not access to journals, are chief obstacles to scientific productivity

The single most important issue obstructing the productivity of biomedical scientists today is the culture of research funding. This finding challenges the belief of some that the lack of "open access" to journal content is a major barrier to scientific productivity. . A survey of 883 biomedical scientists ?in Europe and North America - commissioned by the Publishing Research Consortium found t...

Scientists devise way to measure RNA synthesis on the fly in a live cell

A team of scientists at the University of Chicago has developed a non-invasive laboratory technique that allows them to instantly map when genes are switching off and on in a living bacterium as it becomes exposed to antibiotics and other changes in its environment. .. . "The standard assumption has been that DNA encoding for proteins was the sole...

Public collections of DNA and RNA sequence reach 100 gigabases

The world's three leading public repositories for DNA and RNA sequence information have reached 100 gigabases [100,000,000,000 bases; the 'letters' of the genetic code] of sequence. Thanks to their data exchange policy, which has paved the way for the global exchange of many types of biological information, the three members of the International Nucleotide Sequence Database Collaboration [INSDC,...

Plant pathologists evaluate eco-friendly alternatives to methyl bromide

Alternatives to a powerful pesticide that was found be an ozone depletor are now being evaluated in agricultural production areas of Florida, say plant pathologists with USDA's Agricultural Research Service. . In 1987, the Parties to the Montreal Protocol called for the phase-out of methyl bromide, a soil fumigant used to control soilborne fungi, nematodes, and weeds of more than 100 crops worldw...

MicroRNA tweaks protein that controls early heart development

Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA ?a chemical cousin of DNA ?helps fine tune the production of a key protein involved in the early development of heart muscle. .. The findings, available in the online edition of the journal Nature, may aid scientists in their understanding of how a progenitor cell, or stem cell, decides to be...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine. . Though multiple genetic alterations are associated with melanoma development, scientists have not been able to...
Other Tags
(Date:9/17/2014)... EC-FP5 four-year project, delivering its first release in 2004. ... in several EC projects, as a part of the ... BON), to increase the general awareness of the work ... dissemination of the Fauna Europaea results, the ... e-Publishing tools to prepare data papers for all 56 ...
(Date:9/17/2014)... Copenhagen Centre for Social Evolution and Yale University offers ... weight and -length can partially predict the likelihood of ... and schizophrenia later in life. The study analyzed medical ... diagnoses for up to 30 years, and adjusted for ... published today in the Proceedings of the Royal ...
(Date:9/17/2014)... EAST LANSING, Mich. Mutations in the human retinoblastoma ... Now, Michigan State University scientists have turned to fruit ... cancer gene. , In a paper featured on ... Journal of Biological Chemistry , Michigan State University researchers ... mutations similar to those present in the human cancer ...
Breaking Biology News(10 mins):Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Abnormal properties of cancer protein revealed in fly eyes 2
(Date:9/18/2014)... 2014 “Awesome” is the way Emily ... Accepting Responsibility Today) Internship Program at ARDX ( http://www.ardx.net ... describe the program as “Inspirational” and “Life-changing,” respectively. ... what they would be doing during their summer internship. ... runs and other mindless tasks,” but, instead she was ...
(Date:9/18/2014)... September 18, 2014 T-System Inc. ... electronic physician documentation system — EV™ for ... , After assessing several best-of-breed solutions, Holyoke chose ... with optimizing physician productivity and reimbursement, but also ... which will still be used to capture emergency ...
(Date:9/18/2014)... By Maureen Salamon ... (HealthDay News) -- Migraines in midlife may be associated ... movement disorders in later years, new research suggests. ... between the two brain-based conditions, also suggested that the ... by aura. An aura is a warning sign of ...
(Date:9/18/2014)... Chino Hills, CA (PRWEB) September 18, 2014 ... boot camp, is the fastest-selling fitness business in the country ... to work out, has continued to grow enormously in 2014. ... Boot Camp World Conference, is taking place in Costa Mesa, ... be one of the biggest conferences yet. Founder Bedros Keuilian, ...
(Date:9/18/2014)... How much is a serving? ... factors contributing to the obesity epidemic in the United ... and how to manage portion size during the next ... at Humility House, 755 Ohltown Road, Austintown. , Registered ... informational discussion and answer questions from 12:30 to 2 ...
Breaking Medicine News(10 mins):Health News:ARDX Internship Helps Students to START on the Right Business Path 2Health News:ARDX Internship Helps Students to START on the Right Business Path 3Health News:ARDX Internship Helps Students to START on the Right Business Path 4Health News:Holyoke Medical Center ER Improves Productivity and Reimbursement with T-System 2Health News:Are Migraines in Middle Age Tied to Raised Parkinson's Risk Later? 2Health News:Are Migraines in Middle Age Tied to Raised Parkinson's Risk Later? 3Health News:With Fit Body Boot Camp World Conference Nearing, Founder Explains the Fitness Boot Camp Franchise’s Success 2Health News:With Fit Body Boot Camp World Conference Nearing, Founder Explains the Fitness Boot Camp Franchise’s Success 3Health News:HMHP Workshop Addresses Portion Control 2
Other Contents