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Tag: "rhythms" at biology news

Effective Cancer Treatments Follow The Clock

...fic mechanistic insight into the role of circadian rhythms in sensitivity to such drugs,?said Takahashi. “This is not some vague metabolic difference between day and night. This is a tangible difference in the immune system that influences sensitivity.?/p> The findings may well extend to the effects of o...

After a time-shift, mixed signals from the circadian clock

Circadian rhythms in mammalian behavior, physiology, and biochemistry are controlled by the central clock within a brain structure known as the suprachiasmatic nucleus (SCN). The clock is synchronized to environmental cycles of light and dark. It is well known, from e...

Discovery clarifies role of peptide in biological clock

...y the brain's biological clock to coordinate daily rhythms in behavior and physiology. Neurons in the biologi...howing that VIP couples pacemaker cells and drives rhythms in slave cells. "VIP between SCN neurons is like a rubber band between the pendulums of two grandfa...

Researchers Identify Cause of Early Bird Sleep Disorder

...some of the fundamental mysteries of how circadian rhythms are established and maintained in creatures that have evolved along very different paths. As for the affected individuals, Ptacek said most are able to live normal lives, and some are proud of being able to arise before dawn and get a lot done while...

Gene controlling circadian rhythms linked to drug addiction

...id, suggesting that the gene controlling circadian rhythms is a key regulator of the brain's reward system an...est there may be a link in disruption of circadian rhythms and the tendency to abuse drugs. "Most work on Clock has focused on the brain's master pacemaker, l...

Temperature regulates circadian clock in zebrafish

The biological clock controls the circadian rhythms of a wide range of physiological and behavioral processes, from fluctuating hormone levels to sleep-wake cycles and feeding patterns. While it's well known that circadian clock elements sense and respond to light cycles, much less is known about how ...

A novel method to measure circadian cycles

...night owls. The variation in individual circadian rhythms is an anecdotal as well as experimentally verified...onfirmed that, for both humans and mice, circadian rhythms vary substantially between individuals. This suggests that the genetics of the circadian clock likew...

What can change in the brain? Electrical synapses, research shows

...se junctions probably help regulate specific brain rhythms that occur while you are awake or sleeping. So this work helps us better understand, in a basic sense, how the brain regulates behavioral states." Carole Landisman, currently a neurobiology researcher at Harvard Medical School, is the lead author of...

Travelers can avoid jet lag by resetting their body clocks

...an clock earlier in time so that all the circadian rhythms of the body occur earlier) thereby helping people ...an clock earlier in time so that all the circadian rhythms of the body occur earlier. Dr. Eastman and colleagues at Rush's Biological Rhythms Research Lab st...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

... that may predispose some people to abnormal heart rhythms that lead to sudden cardiac death, a condition affecting more than 300 thousand Americans each year. The gene called NOS1AP, not previously flagged by or suspected from more traditional gene-hunting approaches, appears to influence significantly on...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

...s. "There is a dynamic interplay between circadian rhythms and metabolism," Lazar says. "You don't eat while you are sleeping, and the body needs to take this into account." Study co-authors are Lei Yin and Jing Wang, both from Penn. The research was funded by the National Institute of Diabetes & Digest...

Gene variation increases SIDS risk in African Americans

...e this are known to increase the risk for abnormal rhythms and sudden death. Fortunately, a drug called mexiletine, used to treat patients with arrhythmias, blocks late re-openings of sodium channels at low levels that do not interfere with normal function. Goldstein and colleagues found that the drug res...

More evidence mammals, fruit flies share make-up on function of biological clocks

... relative ease of finding mutants with non-24-hour rhythms and then identifying the genes underlying the altered behavior. These studies in fruit flies have allowed the identification of similar "clock genes" in mammals, which function in a similar manner in mammals as they do in a fly's clock. However, prio...

Possible brain hormone may unlock mystery of hibernation

...irds, they said. Even humans can maintain seasonal rhythms as exhibited by seasonal affective disorder, a recurrent depression characterized by increased sleep, overeating, and weight gain--behaviors similar to those seen in hibernators, Ohtsu noted. "Hibernation is an extreme response to a seasonal environ...

New fruit fly protein illuminates circadian response to light

...nderstanding how light affects circadian (24-hour) rhythms will likely open doors to future treatments of jetlag. The body's 24-hour clock controls a multitude of internal functions such as periods of sleep and wakefulness, body temperature, and metabolism. Although circadian function produces a stable rhyt...

Novel connection found between biological clock and cancer

...er functions that play such a sweeping role in the rhythms and activities of life. "The notion that the clock regulates DNA-damage input and that mutation can affect the clock as well as the cell cycle is novel," says Jay Dunlap, professor and chair of genetics at DMS. "It suggests a fundamental connection ...

First 'encyclopedia' of nuclear receptors reveals organisms' focus on sex, food

...9 nuclear receptors, anatomically and in circadian rhythms ?better known as the biological clock. In the an..., researchers used mice to see how daily circadian rhythms influence the activity of the nuclear receptor superfamily in key metabolic tissues. They found th...

UC Davis researchers move biotechnology closer to replacing electronic pacemakers

...n and gene delivery system to restore normal heart rhythms in pigs with electronic pacemakers, reducing their...h of cells called the pacemaker, generates cardiac rhythms for coordinated contractions and blood pumping. Malfunctions due to aging or diseases can lead to a ...

Bumble bees can estimate time intervals

...rvals. Although many insects show daily and annual rhythms of behavior, the more sophisticated ability to estimate the duration of shorter time intervals had previously been known only in humans and other vertebrates. The findings are reported by Michael Boisvert and David Sherry of the University of West...

Melatonin improves mood in winter depression

...o test the hypothesis that circadian physiological rhythms become misaligned with the sleep/wake cycle during...ing some people to become depressed. Usually these rhythms track to the later dawn in winter, resulting in a circadian phase delay with respect to sleep simila...

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