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Tag: "rheumatoid" at biology news

Breakthrough developments in rheumatoid arthritis reported

... joints and wrists from his research subjects with rheumatoid arthritis. With these clinical features at his sid... Manhasset, NY and more than a 1,000 patients with rheumatoid arthritis. The genes will help tell the story of how the immune system works to create specific anti...

Molecule that destroys bone also protects it, new research shows

...on and inflammation in autoimmune diseases such as rheumatoid arthritis actually protects bone in the oral cavit... has discovered that, in contrast to its action in rheumatoid arthritis(RA), IL-17 actually protects bone in the oral cavity from infectious pathogens such as Por...

Link found between immune system and high plasma lipid levels

... "Those with inflammatory problems such as lupus, rheumatoid arthritis and inflammatory bowel syndrome have a higher incidence of cardiovascular disease, often associated with elevated lipid levels," added co-author Godfrey Getz, MD, PhD, professor of pathology, biochemistry and molecular biology at the Univer...

Microbes start immune response by sneaking inside cells

...ecisely target the body’s inflammatory response in rheumatoid arthritis and some other autoimmune diseases. “In our study, the presence of bacterial microbes inside the cell is what triggers the immune response. That creates a new perspective for developing new drugs,?says senior author Gabriel Nunez, M.D., ...

Cheaper, better disease treatments expected from faster approach to developing antibodies

...nsive processes to develop antibodies for treating rheumatoid arthritis, cancer and other diseases. The new approach developed in collaboration with Dr. Brent Iverson overcomes those obstacles, and has other advantages. "Our approach can provide a significant time savings," said Georgiou, "and it enable...

Antibody signal may redirect inflammation to fuel cancer

...mmune diseases made worse by inflammation, such as rheumatoid arthritis. "We already know that inflammation accelerates skin, cervical and colon cancer, and most likely also lung and breast cancer," she said. "If we confirm that what we've discovered in the mice studies also occurs in human cancers, we may ...

Cracking open the black box of autoimmune disease

...immune diseases such as type 1 diabetes, lupus and rheumatoid arthritis occur when the immune system fails to re...tpn22 is strongly associated with type 1 diabetes, rheumatoid arthritis, lupus and Graves' disease, but the gene had not been previously linked to regulatory T-ce...

Cellulose nanocrystal research could lead to new vaccines, computer inks

...inflammation of blood vessels, including diabetes, rheumatoid arthritis, and certain cancers. Ink jet printing was another research project for Roman. She experimented with using ink jet printers to deposit the crystals because the printers?main focus is precision. Nanocrystals are tiny and pose many difficu...

Monoclonal antibody reduces exacerbations in asthmatics

...py has been shown to be effective in patients with rheumatoid arthritis, ankylosing spondylitis, Crohn's disease...ts of efficacy in asthma patients with concomitant rheumatoid arthritis have been encouraging. Small prospective studies of a soluble receptor directed against TN...

Tiny Tampa Bay fish key to evolution of immune system

...osting drugs to fight cancer and disorders such as rheumatoid arthritis, say scientists at the University of Florida and the University of South Florida, who reported their findings recently in Nature Immunology. "At a basic level, this sea worm tells us about the evolution of the immune response; specifically...

SARS: No evidence that any of the treatments worked

...oydk@who.int A novel strategy for treatment of rheumatoid arthritis A research paper published this week ... describes a possible new experimental therapy for rheumatoid arthritis and other autoimmune inflammatory diseases. The researchers, led by Rikard Holmdahl from L...

UCSD researchers discover internal compass of immune cell

...i-inflammatory drugs could be developed to prevent rheumatoid arthritis, inflammatory bowel diseases, asthma, and many other chronic inflammatory diseases," said Junger. Conversely, drugs that boost these amplification systems and the internal compass could be used to coax neutrophils to migrate to infected ...

UCSD researchers create roadmap to integrin activation

...ells required for inflammation in diseases such as rheumatoid arthritis and inflammatory bowel disease. ...

Proteins anchor memories in our brain

...s in the case of type 1 diabetes, or the joints in rheumatoid arthritis. The discovery, from a mouse model of a human autoimmune condition, suggests that effective strategies to treat autoimmune disease should target not only the "peripheral" sites where autoimmune disease is active, but also the thymus -- t...

Autoimmune disease triggered if T cells miss a single protein early on

...s in the case of type 1 diabetes, or the joints in rheumatoid arthritis. The discovery, from a mouse model of a human autoimmune condition, suggests that effective strategies to treat autoimmune disease should target not only the "peripheral" sites where autoimmune disease is active, but also the thymus -- t...

Key molecular signaling switch involved in allergic disease identified

...n disease, including allergic response, cancer and rheumatoid arthritis," said Carl P. Blobel, M.D., Ph.D, chair...f CD23, ADAMs are also key molecules in cancer and rheumatoid arthritis. For example, he said, ADAMs are essential for activating the epidermal growth factor rece...

How bad is malaria anemia? It may depend on your genes

...normal response to such inflammatory conditions as rheumatoid arthritis or some cancers. Using immature blood cell precursors grown in a dish, the research team showed that adding MIF to the cells decreases both the final number and maturity of red blood cells. The researchers believe this effect can lead to a...

Prevention is the best option: fighting autoimmune diseases

...eases such as multiple sclerosis, Type 1 diabetes, rheumatoid arthritis, asthma and eczema, to determine the risk of disease in patients and their families. ...

Wild vs. lab rodent comparison supports hygiene hypothesis

...sorders include lupus, insulin-dependant diabetes, rheumatoid arthritis and scleroderma. "The most commonly accepted explanation for this high incidence of allergy and perhaps autoimmune disease is the hygiene hypothesis," Parker said. But this hypothesis has not been thoroughly tested in animal studies, he sa...

PTEN: the Treg's handbrake

... to treat autoimmune diseases such as diabetes and rheumatoid arthritis -- is hampered by problems generating sufficient cells to be therapeutically effective. This is because, unlike non-regulatory T cells, Tregs do not proliferate in vitro when stimulated through either their TCR or IL-2 receptor alone. No...

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(Date:10/18/2014)... 2014 Psychological stress and stress-related psychiatric disorders are ... but the molecular mechanisms underlying this relation ... to the development of targeted preventive strategies ... devastating diseases. This work is presented at ... Berlin., Now an international group of researchers ...
(Date:10/18/2014)... a sample of patients with undiagnosed, suspected genetic conditions, ... with a higher molecular diagnostic yield than traditional molecular ... JAMA . The study is being released to coincide ... , Exome sequencing, which sequences the protein­coding region of ... material present in a cell or organism), has been ...
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