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Tag: "reversed" at biology news

Chemical maps hint at drug's effects on schizophrenia

...n in the brain. These lipid changes were partially reversed in patients treated with antipsychotic medications, said Joseph McEvoy, M.D., associate professor of biological psychiatry and study co-investigator. "This technique allows us to identify the specific metabolic changes that are caused by the most ...

Left-right wiring determined by neural communication in the embryonic worm

...left -- appears to be random, with their positions reversed about 50 percent of the time. "What makes this an interesting puzzle to solve is understanding how the left and the right side become different from each other, and how they coordinate their activity so that every worm still has exactly one of each t...

3 proteins may play important role in nerve-cell repair

...he growth of the nerve extensions. The researchers reversed this effect by restoring either GPR3 or GPR12 in the cells. High levels of the three proteins were also linked to higher levels of cAMP, with GPR6 and GPR12 increasing the level twofold to threefold. "Taken together," Saeki says, "our finding...

Angelman syndrome deficits rescued in mice

...alleviated. Edwin Weeber, Ph.D., and colleagues reversed the neurological deficits in a mouse model of Angelman syndrome by preventing the inhibition of CaMKII, an enzyme highly expressed in brain regions affected by Angelman syndrome. The results, which appear in the March issue of Nature Neuroscience ...

Fighting to keep Darwin in the classroom

...n in his classroom. Though an appeals court later reversed his conviction on a technicality, the law lingered on the books, joined by later laws promoting "scientific creationism," and, most recently, "intelligent design." The battle to keep religiously based explanations of the history of life—especially h...

Clues to gene expression in cystic fibrosis will guide research

...are found in around 10% of CF patients. Gentamicin reversed stop codons in the Y122X gene, and helped restore the CFTR protein, improving patients?respiration. Gentamicin itself may not be an ideal drug option, as it may cause serious side effects for some patients, including ear and kidney damage. The aut...

Decoy pill saves brain cells

...rotective function. The decoy, developed by Xu, reversed the outcomes. By tricking calpain, it prevented damage to the receptor and allowed the beneficial reaction to continue. In addition, it interrupted the feedback loop that stoked calpain activation. "This is potentially a treatment for any conditio...

Prion disease treatable if caught early

...dicated that the effects of prion disease could be reversed if caught early enough. The researchers said that ...leagues found that early brain degeneration can be reversed if prions are depleted in neurons. In the new studies published in Neuron, they established that ...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

...hts the fact that 'end stage' heart failure can be reversed and that the heart has the capacity to regenerate itself. It therefore stimulates the search for other strategies and more therapeutic targets in this expanding field of regenerative therapy," he added. LVADs are currently mainly used in those pat...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...he lifespan of obese mice, and found that the drug reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets--some of which are associated with diabetes, heart disease, and other significant diseases related to obesity. The research, led by investigators at Harvard Med...

PET imaging shows young smokers quick benefit of quitting

...of coronary artery disease in young smokers can be reversed quickly if they choose to put out their cigarettes for good, according to a positron emission tomography (PET) imaging study in the December Journal of Nuclear Medicine. "I believe this is the first PET study that shows abnormal coronary function i...

New technology to speed up research into Huntington's disease

...chers also demonstrated that when the stimuli were reversed (so the stimulus that had previously been correct was now incorrect), HD mice struggled with the task although younger HD mice, who had not progressed as far in the disease, eventually learned it. When the mice were then presented with a new pair of...

'Erectile dysfunction' drugs heighten natural anti-cancer activity

... much like nitric oxide, and its production can be reversed by sildenafil. "Impotence drugs won’t cure cancer," Borello cautioned, "but could be used in addition to standard chemotherapy or immunotherapy treatments." The investigators are planning human studies to begin in the next year. ...

A new target for painkillers

...er the drug was given. The highest dose completely reversed the hypersensitivity caused by sciatica, with no a...ain reliever that "about 10 billionths of an ounce reversed the hypersensitivity to pain," McIntosh says. Vc1.1 had a similar effect ?replicating studies by ...

Gardenia fruit compound starting point for diabetes therapy

... addition of genipin to isolated pancreatic tissue reversed high glucose- and obesity-induced dysfunction of insulin-producing beta cells. A derivative of genipin that lacked the chemical's cross-linking activity continued to inhibit UCP2, they reported. That's a good sign for the therapeutic potential of ge...

Reversing 'hibernating' heart muscle focus of UB researchers

... for the adaptation to decreased blood flow can be reversed more completely. The ultimate goal of manipulating these pathways will be to restore full contractile function." Areas of hibernating myocardium are common in patients with heart failure arising from coronary artery disease, Canty noted. "Determin...

Scientists reverse evolution

...ining parts of both Hoxa1 and Hoxb1, he and Tvrdik reversed evolution. "What we have done is essentially go back in time to when Hox1 did what Hoxa1 and Hoxb1 do today," he says. "It gives a real example of how evolution works because we can reverse it." The hybrid Hoxa1-Hoxb1 gene is not fully identica...

Chromosomal abnormalities in sperm higher after vasectomy reversal

Men who have had a vasectomy reversed have a very much greater rate of chromosomal abnormalities in their sperm than do normal fertile men, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic on Wednesday 21 J...

Cycles of cell death, proliferation key to liver cancer

...NK1, prevented the development of liver cancer and reversed the tumor-enhancing effect caused by ablation of IKKƒÒ. "We found that long-term JNK activation leads to cell death; if activated briefly, it stimulates proliferation of pre-malignant and cancerous tumor cells," said Karin. Blocking JNK prevents li...

Study finds 60 new genes controlled by DNA snippet

...according to recent studies. Can cardiomyopathy be reversed by manipulating CArG-SRF? CArG sequences also appear near genes that direct the building of nerve cells and blood vessels, suggesting they may be involved in diseases affecting those tissues as well. In the larger picture, regulatory sequences may...

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