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Tag: "reverse" at biology news

Stem cell therapy successfully treats heart attack in animals

...evelop a widely applicable treatment to repair and reverse the damage done to heart muscle that has been infarcted, or destroyed, after losing its blood supply," says cardiologist Joshua Hare, M.D., professor of medicine at The Johns Hopkins University School of Medicine and its Heart Institute, and senior a...

UCLA cancer researchers shake loose hidden biomarker

...se in whom the cancer has spread. "The ability to reverse the polarity of PSMA from apical to the basolateral could have significant implications for the PSMA as a therapeutic target," the study states. Pairing treatments may be even more important for patients with advanced cancers, for whom few options a...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

...h a growth factor and then injected into the liver reverse a form of hemophilia in mice analogous to hemophilia B in humans, the new study shows. A report of the study appears in the journal Proceedings of the National Academy of Sciences today (Feb. 15). The genetically altered mice lack the clotting subst...

Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

...ics, the real work has only just begun--successful reverse engineering hinges on the ability to reproduce the mechanism of overproduction in new strains. Ideally, the exact sequence of base pairs causing the mutation could be found and then directly introduced into a new strain. Drug companies use chemicals...

New polysaccharide may help combat multidrug resistance in cancer

...tagonists, for example small hyaluronan oligomers, reverse the malignant properties of cancer cells, including proliferation, invasiveness, and drug resistance," explains Dr. Toole. "Hyaluronan oligomers are non-toxic, non-immunogenic, and readily applicable to several proliferative disease processes, especi...

Supercomputers to focus brains on AIDS dilemma

...ly been discovered." The other two HIV enzymes are reverse transcriptase, the target for AZT and other drugs, and protease, the target for the protease inhibitors that had proven so effective until the recent emergence of drug-resistant mutants. The new drug possibilities flow out of a long series of molecu...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

...lomerase RNA and a protein called human telomerase reverse transcriptase, which is related to the reverse transcriptase protein that is important for replicating the AIDS virus. Feigon's laboratory has been...

U-M team recovers ancient whale in Egyptian desert

...nically dead humans and our ability to induce ?and reverse ?metabolic quiescence in model organisms could have dramatic implications for medical care," Roth said. "In the end I suspect there will be clinical benefits and it will change the way medicine is practiced, because we will, in short, be able to buy ...

Buying Time Through Hibernation on Demand

...nically dead humans and our ability to induce ?and reverse ?metabolic quiescence in model organisms could have dramatic implications for medical care," Roth said. "In the end I suspect there will be clinical benefits and it will change the way medicine is practiced, because we will, in short, be able to buy ...

Norovirus, AIDS vaccine and Hepatitis Virus

...made noninfectious by removing the gene that makes reverse transciptase (a protein the virus requires to replicate). Four macaques were injected with the noninfectious vaccine, while two control animals remained unvaccinated. Both groups were challenged with SHIV. All four of the immunized macaques became in...

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

...performing cardiac studies that explore drugs that reverse the conditions of animals. The JNM articles on small animal imaging, with numerous SNM members as authors, are listed here. * Welch's co-author of "Preparation, Biodistribution and Small Animal PET of 45Ti-Transferrin" is Amy L. Vavere, Ph.D., ...

Gene therapy for Parkinson's disease moves forward in animals

... rats, researchers used gene therapy to completely reverse abnormal movements called dyskinesias in some of t...c dose would be better for you. As for efforts to reverse impaired movements in rats, scientists used 33 animals with severe dopamine depletion and transferre...

First real-time view of developing neurons reveals surprises, say Stanford researchers

... to indicate their activity. Moving the square the reverse direction triggered a different population of neurons to light up. "At first we felt like we let some air out of our own tires with this finding," said Smith. His previous work had supported the prevailing idea that neurons need a period of fine-tun...

Studies reveal methods viruses use to sidestep immune system

...s. Again they found that protease inhibitors could reverse the effects of NS3/4A, allowing this immune pathway to be restored to shut down HCV replication. Hepatitis C is a chronic disease that affects 4 million people in the United States, making it the nation's most common blood-borne infection. It is tra...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

... rats, researchers used gene therapy to completely reverse abnormal movements called dyskinesias in some of t...c dose would be better for you. As for efforts to reverse impaired movements in rats, scientists used 33 animals with severe dopamine depletion and transferre...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...herapy methods that specifically target muscle may reverse the symptoms of a rare form of muscular dystrophy,...of the enzyme. "Gene therapy has the potential to reverse the course of the disease with a single treatment," Koeberl said. The researchers delivered the gly...

Genome-wide mouse study yields link to human leukemia

... already have a drug, decitabine, that we know can reverse the effects of methylation," says Plass. "We are just beginning to figure out how it best works in humans, but simply knowing that we have a new target that may be meaningful in treating leukemia is a big step in the right direction." Grants from th...

Controversial drug shown to act on brain protein to cut alcohol use

...g treatment advocates impressed with itsability to reverse withdrawal symptoms and craving for alcohol andvarious drugs of abuse. It has been used outside of the U.S. to treataddiction by American and other clinicians. But its side effects,including hallucinations, which made it popular in the 1960s drugcult...

UAB scientists discover the origin of a mysterious physical force

... out the electric field, and on some occasions, to reverse it. This abnormal behaviour was discovered by the same researchers and published in Physical Review Letters in April 2004. The scientists have now discovered that this strange property is responsible for the hydration force that acts when water is s...

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