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Tag: "reverse" at biology news

Viral 'fitness' explains different resistance patterns to aids drugs

...e study results, Bangsberg said, "A non-nucleoside reverse transcriptase inhibitor (NNRTI), for example, can ... two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

Therapeutic prospects beyond Vioxx

...GES-1 actually elevated prostacyclin, the complete reverse of what was observed with COX-2 inhibitors. "Selective inhibitors of mPGES-1 may retain much of the benefit of drugs like Vioxx and Celebrex, while diminishing the risk of heart attack and stroke by having precisely the opposite effect on prostacycli...

Study shows that cells have a natural defense against HIV

... used antiretroviral drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). These drugs prevent HIV from making the cDNA copy of its RNA genetic material. The researchers exposed newly infected cells to the drugs and then measured changes in the amount of cDNA over time. These experiments...

Access to antiretrovirals unlikely to reduce HIV infection rates

...ntial part of any strategy if it is to contain and reverse the AIDS epidemic. The model presented here can support health policy makers in resource-poor settings in their difficult task of allocating limited amounts of antiretroviral drugs for the best outcome for their populations. ...

How 'hot' emotional brain interferes with 'cool' processing

...dder and all you see is bad news." "Our aim is to reverse that with drug treatment, so we're using these kinds of studies to determine whether particular antidepressants influence the response of that ventral system. And what is particularly exciting is that this method allows us to look directly at the neu...

Butterflies lose body fat during metamorphosis

...e energy would be required in hibernation, but the reverse must be true since a great deal of metabolic activity is occurring in the butterfly chrysalis." Because of this energy expenditure, Connor and his colleagues surmised that butterflies experience a great loss in body fat during metamorphosis. Using ...

Engineered mouse mimics cognitive aspects of schizophrenia

...exibility; they were less able than normal mice to reverse their association of a particular odor with a rewa...Importantly, found the researchers, they could not reverse these cognitive deficits by using the antibiotic to damp down the dopamine machinery. This finding s...

Stem cell study for patients with heart attack damage seeks to regenerate heart muscle

...from healthy donor bone marrow that might possibly reverse damage to heart tissue. A unique benefit of the stem cell product is that it is given to patients through a standard IV line. Other therapies require delivery to the site of the disease through catheterization or open surgical procedures, but this ...

Cancer cells suppress large regions of DNA by a reversible process that can be tackled

...eam also hope that new cancer therapies, which can reverse DNA methylation, will restore the cell's normal regulation and treat and prevent cancer. ...

DNA gene vaccine protects against harmful protein of Alzheimer's disease

...humans. The researchers also plan to see if it can reverse the size of established plaques in the brains of mice. ...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

... have been shown to proliferate, differentiate and reverse hyperglycemia in immunodeficient diabetic mice and allogeneic out-bred pigs. However, humans and Old World primates have naturally occurring antibodies that are directed against antigens that can cause hyperacute or acute humoral rejection. To comb...

Scientists directly view immune cells interacting to avert autoimmunity

...ory T cell-based therapy that can prevent and even reverse the course of autoimmune diabetes in mouse models, and this study begins to analyze how such protection occurs in vivo, she explained. "By understanding the interplay between pathogenic cells and protective cells, we hope to be able to refine the th...

From one cell, many possible cures

...bone . . . create new cartilage or skin . . . even reverse nerve damage. Human stem cells offer tremendous hope for the development of revolutionary medical treatments for these and a variety of other human health problems. Up until now, however, stem cell research has been slowed by ethical controversy -- ...

Recreating 'Flowers for Algernon' with a happy ending

... statins, a popular class of cholesterol drugs, to reverse the attention deficits linked to the leading genet...ilva. "Statins act on the root of the problem and reverse these deficits. This enables the process of learning to physically change the brain and create memo...

SLU researchers uncover direct evidence on how HIV invades healthy cells

...al to the infection's survival. The first protein, reverse transcriptase, converts the ribonucleic acid (RNA)...and drug combinations (cocktails) exist to inhibit reverse transcriptase and protease. As of yet, there are no drugs to counter integrase. By using a biophysi...

Genetic defenders protect crops from fungal disease

...ville said. "This suggests it might be possible to reverse engineer crops like wheat with Arabidopsis PEN genes to help control powdery mildew and other destructive diseases, thus minimizing the need for pesticides." ...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...d gene therapy and RNA interference to genetically reverse sickle cell disease (SCD) in human cells. This research is the first to demonstrate a way to genetically correct this debilitating blood disease using RNA interference technology. To prevent the production of the abnormal hemoglobin that causes sick...

Mammalian Transcriptome Mapped

...ed into antisense RNA, then the transcript has the reverse sequence as the original DNA sequence. Antisense RNA transcripts can exert function because they can bind to the RNA transcripts for which they are complementary messengers and modulate their expression into proteins. In fact, synthetic antisense mo...

HIV inserts into human genome using a DNA-associated protein

...nter a cell and convert RNA into DNA by the enzyme reverse transcriptase and then integrate that DNA copy into the DNA of the host, using the integrase enzyme. The new viral particles are made by transcription of the viral genome, as with any cellular genes. If the cell divides, the viral DNA is copied and i...

UK is first to administer new anti-clotting technology

...e time providing physicians the ability to rapidly reverse the effects of the blood thinner to help safeguard...teers as well as the antidote's ability to quickly reverse its effects. Although other new antithrombotics are undergoing testing in the U.S., this drug is bel...

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