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Tag: "reverse" at biology news

Study uncovers a lethal secret of 1918 influenza virus

... the tissues of victims of the great pandemic in a reverse genetics process that enables scientists to make fully functioning viruses. "In 1918, the existence of viruses had barely been recognized. In fact, the influenza virus wasn't identified until 1933. Thanks to recent technological advancements, we ...

Pregnancy hormone key to repairing nerve cell damage

...epresents a new insight of how we might be able to reverse some of the effects of the disease and improve the quality of life for those who live under its influence." ...

Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu

...nuated viruses, but the new focus is on the use of reverse genetics techniques to combat emerging bird flu pandemic threats. To that end, researchers intend to: Characterize the function of the influenza viruses using a structure-based approach; Develop simulations of the molecular dynamics involving...

Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates

...lly replicated in other hospitals in an attempt to reverse the rapid increase in CDI in the NHS. This finding is especially important because CDI rates are rising rapidly in the UK and a new more virulent strain has recently been identified2 A 2005 study by the Healthcare Commission3 found that 38% of NHS ...

Reactivated gene shrinks tumors

...ot been known whether such activity would actually reverse tumor growth in primary tumors. The new MIT study shows that re-activating p53 in mouse tumors dramatically reduces the size of the tumors, in some cases by 100 percent. "This study provides critical genetic evidence that continuous repression...

Turning a cellular sentinel into a cancer killer

...genetically engineered the mice so that they could reverse p53 inactivation by giving the animals the antibiotic doxycycline. They suppressed p53 protein levels by using RNA interference (RNAi) that had been modified so that RNAi could be switched off by the antibiotic. The RNA interference technology was de...

Reversing cancer cells to normal cells

...ll types and the ability to inhibit Nodal and thus reverse the melanoma cell back toward a normal skin cell provide a previously unknown target for regulating tumor progression and metastasis. Dr. Hendrix’s distinguished lecture is part of a session titled the cell microenvironment in development and ca...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

... Patients were treated with drugs which encourage reverse remodelling of the heart, prevent atrophy and prevent the heart from shrinking beyond its desirable size. The drugs used were lisinopril, carvedilol, spironolactone and losartan in the first stage of treatment and bisoprolol and clenbuterol in the se...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...earch team also wanted to see if resveratrol could reverse the changes in gene expression patterns triggered by high calorie diets. Using liver tissue of five mice at 18 months of age from each group, the team performed a whole-genome microarray and identified which genes were turned on or off. The research...

Proteins may predict lung transplant rejection

...hronic rejection appear, it is usually too late to reverse it, she said. If doctors can predict which patients are beginning to reject the transplanted organ, they could try to head it off, she said. The study, "Proteomic biomarkers of chronic lung allograft rejection," was carried out by Wendt, Tereza Ce...

Signal protein shows promise for blocking tumor promoters in skin cells

...archers will determine whether Srcasm can actually reverse tumor formation in skin. Seykora's team has already prepared an adenovirus and mice with the tumor-forming Src kinases expressed in their skin. Within six months, the group expects to know whether Srcasm can decrease squamous cell carcinoma formation...

Mutant gene causes severe kidney disease in infants

...s of plce1, they hope to identify drugs that could reverse the damage to podocytes and the glomerulus caused by the disease. "Because PLCE1 is an enzyme, we have a much better chance of finding ways to modify its activity," Hildebrandt explains. "Using the zebrafish model, we can do high-throughput screen...

Researchers seek to design first treatment for neuroAIDS

...firm that MLK and GSK-3b inhibitors are can indeed reverse nerve damage in cell cultures. CNND researchers will test the compounds in mice with HAD to determine that they work in a living system genetically similar to humans. If these tests are successful, human studies will proceed with an existing MLK3 inh...

Cracking the egg

...ragments of mouse egg cDNA. The cDNA fragments are reverse coded from messenger RNA and therefore indicate which genes are being expressed. They identified 5,400 active genes in the fully grown egg, about a tenth of which are unique to egg cells. Interestingly, the process of getting ready for fertilization ...

Neural networking nanotubes

...lm to the nerve cells. The net effect is a kind of reverse amplification of the applied voltage that stimulates the nerve cells without damaging them. Kotov and his colleagues report that such devices might find use in pain management, for instance, where nerve cells involved in the pain response might b...

'Erectile dysfunction' drugs heighten natural anti-cancer activity

... foreign material. The impotence drugs seem to reverse this process, stopping the production of nitric oxide by MDSCs thereby allowing other immune cells to "see" the cancer and attack it, says Paolo Serafini, Ph.D., a research fellow in Borrello’s laboratory and lead author on the paper. Nitric oxide...

Protein splicing upsets the DNA colinearity paradigm

...an also splice the peptide fragments together in a reverse order to that encoded by the protein's DNA sequence template. This takes the possible number of antigens from any one protein into potentially thousands of sequence configurations. The sequence of the first human cancer-specific antigen, which was...

Novel regulatory mechanism identified for key tumor suppressor p53

...d, the site we found cannot be methylated. But the reverse is not the case." ...

U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication

...ar signalling pathways. To do this, they are using reverse genetics technology, where researchers begin with a gene and figure out its function. These studies will allow the team to identify the genes that enable the virus to cause disease, laying the groundwork for antiviral drug development. "Increa...

Special chip provides better picture of salmon health

...onservation of wild salmon, offering the chance to reverse the decline in Britain's salmon population." ...

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