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Tag: "retroviral" at biology news

Study reveals candidate targets for anti-retroviral therapeutics

...st ?elements) encode proteins that are homologs of retroviral proteins. The proteins encoded by Ty elements and the steps of the life cycle in yeast are similar to the proteins encoded by retroviruses and their life cycles in animal cells. Scientists believe that these simple elements in a single-celled organis...

Chimp genome reveals a retroviral invasion

...finished chimpanzee genome sequence for endogenous retroviral elements, and found one (called PTERV1) that does ...To further explore the evolutionary history of the retroviral elements, the authors compared the sequences of gag and pol, as well as the LTR sequences, for each ...

Retroviral resistance gene found

...tephen Goff and colleagues have identified a novel retroviral resistance gene, called FEZ1, that can mediate a p...ratory rat cell line caused a significant block to retroviral infection ?retroviruses were able to enter the host cells and synthesize the viral DNA, but were exc...

Crisis in African fish supplies looms, experts warn Africa leaders

...y infections while increasing the effectiveness of retroviral drugs. "Small fish ponds are a valuable addition to farms without substantially adding to the labour burden," says Daniel Jamu, the WorldFish Center's program director for southern Africa, adding that HIV and AIDS affected families in Malawi, includ...

Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice

...y infections while increasing the effectiveness of retroviral drugs. "Small fish ponds are a valuable addition to farms without substantially adding to the labour burden," says Daniel Jamu, the WorldFish Center's program director for southern Africa, adding that HIV and AIDS affected families in Malawi, includ...

HIV inserts into human genome using a DNA-associated protein

... the machinery that helps dictate the placement of retroviral integration sites within chromosomes," says Bushman. Bushman notes that finding that LEDGF is part of the cellular apparatus necessary for HIV replication is important to the field of gene therapy. Controlling where gene-therapy vehicles insert in t...

A clue from macaques yields evidence for impaired retroviral defense genes in humans

...n were responsible for this difference in battling retroviral infection. This prompted the Malik and Emerman gro... history corresponding to relatively low levels of retroviral infections may have allowed impaired versions of retroviral defense genes--such as the hobbled versi...

New human retrovirus originated in mice

...st really solid example of an authentic xenotropic retroviral infection in a human being," said Ganem. Accordin...RNASEL is an important part of the defense against retroviral infection. This is the first evidence in humans of findings that were previously made only in vitro....

Scientists discover new regulating mechanism in cells

...ause it has something important in common with the retroviral proteins. The mRNA in both cases does not pass through the processing step of the four-step protein-making process. Normally, that processing step also adds a signal to the mRNA that facilitates the final making of the protein. Because mRNAs like t...

Scientists resuscitate a 5 million-year-old retrovirus

...(HML2) family, an evolutionarily "young" family of retroviral elements. They aligned HERV-K(HML2) elements, det...' that may be responsible for the synthesis of the retroviral particles that can be observed in some human cancers such as germline tumors and melanomas," says He...

Researchers discover that sheep need retroviruses for reproduction

...retroviruses can be considered remnants of ancient retroviral infections, Spencer said. Many scientists believed these endogenous retroviruses were junk DNA, he said. "Indeed, these endogenous retroviruses are usually harmless and generally contain mutations that prevent them from producing infectious retr...

Cornell researcher helping develop quick, cheap HIV/AIDS test

...," explains Baeumner. "If they get the appropriate retroviral treatment, their life span can be increased by many years. CD4 counts assist in the decisions on when to initiate and when to stop the treatment, which makes this test so important. "While such testing is routine in Western countries -- and used re...

UCLA AIDS Institute researchers find a peptide that encourages HIV infection

...ty of HIV-1 to enter a broad range of human cells, retroviral vectors are currently being explored as vehicles f...rote. "In this area, at least, agents that enhance retroviral uptake could contribute to an emerging field of medicine." "So many people have tried to deliver...

Ancient retrovirus sheds light on modern pandemic

...r many millions of years, and so humans share many retroviral DNA fragments with their primate cousins. Such vestiges of primitive infection, rendered inactive by eons of genetic mutation, make up about 8 percent of the human genome. Innate protection against PtERV1 in humans could be credited, the researcher...

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