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Tag: "retinoblastoma" at biology news

Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors

...ancer Institute quantifies the risk of hereditary retinoblastoma survivors developing specific subtypes of soft tis... this risk persists for decades after the original retinoblastoma diagnosis. The findings emphasize the importance of regular medical surveillance for these patients,...

Tumor-suppressor gene is critical for placenta development

.... Those conclusions come from a new study of the retinoblastoma (Rb) gene in mice. In humans, this gene, when mutated, raises the risk of a rare cancer of the eye called retinoblastoma. Two decades ago, it was identified as the first tumor-suppressor gene, a class of genes that protects cells from becoming cancer...

St. Jude announces breakthrough in eye cancer treatment

... new, locally applied treatment for the eye cancer retinoblastoma that not only greatly reduces the size of the tumo...mpler, more effective and less-toxic treatment for retinoblastoma that would eliminate the need for the current, complex therapy, according to senior author Michael D...

Why mice don't get cancer of the retina

... are more susceptible to developing the eye cancer retinoblastoma than mice because, unlike humans, mice can compensate for the loss of activity of a gene critical to normal retinal development , according to results of a study by investigators at St. Jude Children's Research Hospital. The study, published today in...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...e UTMB group discovered that the tumor-suppressing retinoblastoma protein is present at markedly reduced levels in c...ntify a protein known as NS5B that attaches to the retinoblastoma protein, a critical tumor suppressor, and accelerates its breakdown," Lemon said. He continued: "The...

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

... nuclear antigen)--mediates the degradation of the retinoblastoma protein, an important molecular brake for cell pro...edings of the National Academy of Sciences. The retinoblastoma protein (Rb) is a major regulator of several genes in charge of cell proliferation and cell-cycle re...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...omas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with ...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...omas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with ...

Engineered skin offers clues to melanoma development

...omas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with ...

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