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Tag: "retinal" at biology news

'Lucky 13' as new gene discovery offers further hope for childhood blindness

... the retina. Protein transport is essential within retinal photoreceptor cells as they are long, thin cells w...s being tested are specific for different kinds of retinal degeneration. All in all its an exciting time for eye research and a very promising one for people w...

Surprising origin of cell's internal highways

...the growing ("plus") ends of microtubules in human retinal epithelial cells with a fluorescent molecule, videotaped their growth and carefully followed the tracks back to their origin. "We show that not only the centrosome, but the Golgi also makes microtubules," Kaverina said. "And unlike centrosomal mi...

First clinical trial of gene therapy for childhood blindness

...ital amaurosis (LCA), which is a type of inherited retinal degeneration. This disease causes progressive dete...eading eye surgeon Mr James Bainbridge and leading retinal specialist Professor Tony Moore. Professor Ali said: "We have been developing gene therapy for ey...

MU researcher placing eye implants in cats to help humans see

...se, retinitis pigmentosa, that causes the death of retinal cells and, eventually, blindness," Narfstrom said....g the protection the implants might provide to the retinal cells that are dying due to disease progression with the hope that natural sight can be maintained m...

Gene therapy for blindness clears hurdle in mice

...dicine. "We work with rhodopsin, which is the main retinal protein. Without it, or if it is mutated, people simply won’t see." Mutated forms of the rhodopsin produce a toxic protein in the retina that kills cells that receive light. People with the disease usually notice symptoms between the ages of 10 an...

Stem cell therapy shows promise for rescuing deteriorating vision

...ose vision would typically be lost to degenerative retinal disease, the cells were shown to protect vision an...ision. "On their own, they were able to support retinal cells and keep them alive," says Lund, who has conducted pioneering studies of cell therapy for eye ...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

...potential for developing therapies for people with retinal and macular degenerative diseases that are untreat...ansplanted into three different types of mice with retinal degeneration caused by distinct genetic defects involving malfunctioning or degenerating rods. The t...

How ants find their way

... ants searched for the food at 20cm away where the retinal size of the landmark was the same." To analyse the ants' powers of recall an ambiguous situation was set up. Ants were trained to search for food between two cylinders of different sizes and then tested with the training cylinders replaced by two c...

Light-sensitive photoswitches could restore sight to those with macular degeneration

...e restored some light sensitivity to the remaining retinal cells. Isacoff, Kramer, Flannery and Trauner have now joined forces with 9 other researchers from UC Berkeley and LBNL, as well as from Stanford University, Scripps Institution of Oceanography and the California Institute of Technology, to perfect ...

Why mice don't get cancer of the retina

... the loss of activity of a gene critical to normal retinal development , according to results of a study by i...ests that Rb and p107 compensate for each other in retinal progenitor cells and prevent the deregulated proliferation of the cells that leads to retinoblastoma...

Study provides first look at the 'birth' of a retina cell

...ls of specific diseases, such as macular and other retinal degenerations. Gene profiling of rods and cones in disease models at various stages of pathogenesis could help scientists identify molecular targets for drug treatment. Swaroop is hopeful that his research group can use the fluorescent protein to i...

Bone marrow may restore cells lost in vision diseases

...ef that a cell layer vital for eyesight called the retinal pigment epithelium, or RPE, is a nonrenewable reso...lace cells lost to injury or disease. "In people, retinal pigment epithelium can become damaged with age," said Jeffrey Harris, a graduate student in the depa...

Neural stem cell gene plays crucial role in eye development

...ypes in the nervous system. In the developing eye, retinal neural stem cells differentiate to form the neuron...at, in mice, disruption of the SOX2 gene in neural retinal stem cells leads to a kind of abnormal development of the eye called microphtalmia, or small eye. Ap...

Schepens scientists are first to discover angiogenesis switch inside blood vessel cells

...can also nourish cancer tumors and damage delicate retinal tissues when uncontrolled. The angiogenic process is triggered by what the body perceives as a need for additional blood flow. In the case of disease, it is a mistaken need. In response, the body sends growth factors (such as VEGF) to blood vessel...

UF scientists restore sight to chickens with blinding disease

...ring therapy for children who suffer from blinding retinal diseases." Like people, chickens possess color vi...ve restored sight and slowed degeneration, but the retinal cells still degenerate. But Semple-Rowland thinks the time necessary to turn these research results...

'Prosthetic' retinal cells let blind mice see light

...thway to restoring vision in people with inherited retinal degeneration, researchers have engineered cells in...d a gene for a light-sensitive protein into "inner retinal neurons" in a strain of mice with photoreceptor deficiency that resembles the defect in such inherit...

A case of mistaken molecular identity

...micry can also upset the delicate machinery inside retinal cells. Levin and his team found that antibodies geared to attack T. cruzi also block rhodopsin, a molecule that converts light into electrical impulses sent to the brain. "Rhodopsin takes light and transforms it ?that's its function," said Levin. To...

Chemical signaling helps regulate sensory map formation in the brain

...p of axons ?the projections that grow out from the retinal neurons and into the brain. The wandering axons use these signals to locate their destinations in the map. Twenty years later, in 1983, Alfred Gierer developed computational models of this process. His models indicated that at least two counterbala...

New gene reduces retinal degeneration in fruit flies

...at alterations in this new gene greatly reduce the retinal degeneration caused by a different mutant. They named this new gene Lazaro after the novel Lazarillo de Tormes, in which the orphan boy Làzaro helps a blind man see. Of the molecules known to control TRP channels, a key player is diacylglycerol, kno...

Retinal scans eyed for New Mexico show cattle

... regional livestock fairs. Encinias used a $3,000 retinal scanner not much bigger than a small video camera ...he data to a computer database. In addition to the retinal image, the device records the date, time and a global positioning satellite coordinate of the locati...

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