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Tag: "restriction" at biology news

Researchers find link between food odors and lifespan in fruit flies

...reverse the longevity-extending effects of dietary restriction in fruit flies. "Not only can they not have the...hat longer lifespans in those subjected to caloric restriction were not simply a result of slower metabolism. "A simple way to get a fruit fly to live longer is...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

...lass II human leukocyte antigen (HLA), serves as a restriction element for specific T cells. Researchers must clone this restriction element and other class II HLA and transfer them into recipient cells, along with the cDNA library. ...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...flies see none of the benefits from either calorie restriction or treatment by resveratrol. The mammalian version...downstream indicators of its activity. Calorie restriction and exercise have also been previously shown to increase the number of mitochondria in the liver. M...

Powerful genome ID method extended to humans

...to handle the massive amounts of data created by a restriction mapping technology known as "optical mapping." Res...e been divided into orderly fragments by so-called restriction enzymes. By imaging large numbers of an organism's DNA molecules, optical mapping can produce a m...

Air travel and flu: Post-9/11 restrictions delayed start of season

... of spread of flu. This does not prove that travel restriction would be effective in altering the course of a flu pandemic, but it does provide evidence that air travel plays a significant role in the annual spread of flu in the United States. The findings will help plan for the next flu pandemic. ...

Cutting calories slightly can reduce aging damage

...portance because it shows a mild degree of caloric restriction - just enough to prevent weight gain with advancing age - can have beneficial effects against aging. From a scientific perspective, he added, it is important to learn that RNA is a very good marker of aging damage. "I'd never really thought about RN...

Diabetes research takes wing thanks to long-lived fruit fly

...is also involved in determining life span. Caloric restriction ?limiting the calories an organism ingests ?generally increases lifespan in organisms ranging from worms to flies, and maybe humans. Somehow, JNK and the insulin receptor together seem to work in tandem to affect life span. "We're learning that an o...

Study supports 'urgent' need for worldwide ban on lead-based paint

...people. In Singapore, which enforces the same lead restriction on new paint as the United States, lead levels were significantly lower. "Paint manufacturers are aggressively marketing lead-based paints in countries without lead content restrictions," says Clark, professor of environmental health at UC. "In som...

How IVF could be causing genetic errors in embryos

...n 1 in 75,000 births (involves intrauterine growth restriction and subsequent poor growth). Gnas ?plays a role in cell signalling and is associated with McCune-Albright syndrome (involves bone, hormone and skin abnormalities), pseudohypoparathyroidism Ib (involves inadequate levels of calcium and excessive leve...

Thinner and younger

...aton Rouge is reporting that six months of calorie restriction reduces two key markers of aging: fasting insulin ...demonstrated that stringent and consistent caloric restriction increased the maximum lifespan in mice and rats by about 30 percent and protected them against ather...

UCLA paper examines how one disease may prevent another

...seases that benefit from severe caloric or protein restriction include kidney failure, type-II diabetes, inflammatory bowel disease and morbid obesity. Overall, Stiehm proposed that new evidence can be found for using certain viruses to treat diseases such as HIV, which do not respond to other medications. "T...

Losing sleep undoes the rejuvenating effects new learning has on the brain

...rkeley, and Stanford University. The paper, "Sleep restriction suppresses neurogenesis induced by hippocampus-dep...come from the task, the researchers noted. Sleep restriction prompts use of a secondary strategy On the other hand, the sleep-restricted rats that were require...

Do the Europeans turn ill sitting up so late?

...itute of Biomedicine. The objective of this sleep restriction research is to characterize the physiological and ...hift work, socio-economic constraints or voluntary restriction of sleep, due to life style. This can result in performance decrements, mood disorders, increased ac...

New technique multiplies life span in simple organisms

...- when the SIR2 deletion was combined with caloric restriction and/or a mutation in one or two genes, RAS2 and SCH9, that control the storage of nutrients and resistance to cell damage. Human cells with reduced SIR2 activity also appear to confirm that SIR2 has a pro-aging effect, Longo said, although those res...

New clues to the dark side of a key anti-tumor guardian

...suggesting that decreased p53 activity and calorie restriction may influence lifespan through a common molecular mechanism. Because neurons are less prone to tumor formation than other cell types, and because disruption of p53 activity in neurons was sufficient to extend lifespan in the fruit fly, the new findi...

Biotechnology's newest chemical tool

...erases will become a standard laboratory tool like restriction endonucleases. Earlier studies had suggested that the transfer of chemical groups larger than a methyl group would not be possible, in part because replacing AdoMet's methyl group lowered the chemical reactivity of the compound. To overcome this pro...

NHGRI expands effort to revolutionize sequencing technologies

... addition, they will use optical mapping to create restriction maps to help assemble the genome once it is sequenced. The group will then demonstrate how to combine the sequence and maps into distinct haplotype sequences. Gregory L. Timp, Ph.D., University of Illinois at Urbana-Champaign. $2.1 million (3 years)...

Researchers find how some antibiotics kill bacteria

...nt of bacterial resistance. "There is a voluntary restriction on the use of rifamycins in treating infections other than tuberculosis and meningitis due to the fear of spread of resistant mutations," said Vladimir Svetlov, a study co-author and a research associate in microbiology at Ohio State. "Those mutatio...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

...ne Bridge's Red/ET cloning system does not require restriction enzymes and allows the engineering of large DNA se...on and modification of DNA molecules regardless of restriction sites and is particularly useful for the rapid generation of targeting vectors, modification of BACs...

New lifespan extension genes found

... for all of the life-prolonging effects of caloric restriction in yeast, Lin said. In yeast, the effects of agin...ed sequences. The researchers showed that caloric restriction drastically reduces recombination of ribosomal DNA, and that deleting Hst2 and Sir2 blocks this effe...

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