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Tag: "restore" at biology news

Common cancer gene sends death order to tiny killer

...non, the work could lead to treatments that aim to restore the missing microRNA to cancer cells. ...

Cells re-energize to come back from the brink of death

... might represent the time it takes for the cell to restore enough mitochondria to allow the cell to function normally.” The discovery that GAPDH appears to save cells from CICD suggests that blocking this enzyme would kill abnormal cells that lack caspase activation and cannot undergo apoptosis. That st...

'Lucky 13' as new gene discovery offers further hope for childhood blindness

...jecting genes into the eye of patients with LCA to restore their sight. The finding of the new LCA gene, base...en a tenth of the missing protein may be enough to restore vision. So our findings, together with the recently announced clinical trials, hold great promise." ...

Prey not hard-wired to fear predators

...roduction isn’t simply to save a species; it is to restore the natural functions of wild places. When the predator-prey relationship comes back into balance, impacts ripple through the system. For example, when wolves returned to the Yellowstone region, they caused a cascade of events including a change in...

Mice with a migraine show signs of brain damage

...racious demand for energy as the organ attempts to restore the delicate chemical balance that is lost in the ...ous appetite for oxygen as it works frantically to restore the proper chemical balance. Oxygen-rich blood pours into the area to allow brain tissue to work ove...

First clinical trial of gene therapy for childhood blindness

...ally. Restoring the activity in these cells should restore vision. The operation delivers the normal genes to the retina, using a harmless virus or "vector" to carry the gene into the cells. The vector has been manufactured for this trial by Targeted Genetics, Seattle, USA. Previous work using animal mod...

Fat screen delivers plant-derived chemical with antidiabetic effects

...s, work through a counterintuitive mechanism: they restore insulin sensitivity by activating a central promot...positive effect on fat" that ultimately appears to restore insulin response without some of the side effects attributed to TZDs, Tontonoz said. The findings...

In obesity, brain becomes 'unaware' of fat

...efore bypass leptin resistance in obese animals to restore energy balance, according to the researchers. In most adults, body weight is relatively constant despite large variations in daily food intake and energy expenditure, Cowley explained. Energy balance is regulated by neural and hormonal signals tha...

Study shows isolation of stem cells may lead to a treatment for hearing loss

...potential to regenerate the damaged hair cells and restore normal hearing. The team has already begun animal studies to explore the use of cochlear stem cells in well-established hair cell ablation models and in deaf mouse mutants with predictable patterns of early hair cell loss. This line of research wil...

Better assessment of transfusions could save blood

...r of red blood cell (RBC) transfusions in order to restore proper hemoglobin levels. New research shows that alternative treatments may lead to fewer transfusions, conserving critical blood supplies in hospitals. The report is published in Seminars in Dialysis. Phlebotomy, the removing of blood from the bo...

OHSU surgeon implants donated tissue allografts

...atients. The opportunity to correct disability and restore joint function offers the patients the chance to return to a healthy, pain-free and productive life. Crawford said the collaboration between CTS, JRF and OHSU "has been exciting and I am delighted I could be an integral part of bringing this part...

How appetite-stimulating brain cells work overtime during fasting

... program, including hunger, to preserve energy and restore fat levels, he said. Now, "a series of studies, including those reported in this issue of Cell Metabolism by [Diano and colleagues] have elegantly demonstrated that hypothalamic responses to food deprivation involve at least three hormones, two c...

Hybrid molecule causes cancer cells to self-destruct

...stem by symbiotic bacteria that feed on fiber, can restore healthy cell functioning. Efforts to use butyrate as a general drug for tumors elsewhere in the body, however, have been hindered by the high doses of the compound needed to effectively eradicate cancer. To get around this problem, scientists hav...

Misclassified for centuries, medicinal leeches found to be 3 distinct species

...or use as a prescription medical device that helps restore blood flow following cosmetic and reconstructive surgery, Hirudo verbana has not been approved by the FDA and has no special conservation status. "This study is a great example of why the field of taxonomy [the science of classification of organis...

UW launches study testing adult stem cells for heart damage repair

...isability to the patient. While cardiologists can restore blood flow in some cases, the heart muscle can be irreversibly damaged, leading to significant disability, progressive heart failure and often death. ...

Gene therapy for blindness clears hurdle in mice

...ne to the retina, will show whether we are able to restore vision in this model or not." If both steps are perfected, scientists plan to study the treatment in a larger animal model and then possibly move to a human clinical trial....

Amur leopard still on the brink of extinction, scientists say

...n is not completely depressed and is still able to restore itself. But for long-term survival, at least 100 animals are needed. "Conservation of large predators needs vast territories with minimal anthropogenic changes, which is difficult," said Dr. Dmitry Pikunov, the coordinator of the 2007 leopard cens...

Stem cells decrease ischemic injury and restore brain function

...rder to protect the brain from ischemic injury and restore brain functions. Their presence in brain tissue is sufficient to induce a protective reaction." Various cells are involved in this reaction, among which the microglia, which has always been thought to have a toxic and inflammatory role. "Instead, ...

How to manage forests in hurricane impact zones

...ge effects," says Stanturf. "The infrastructure to restore access and communication should be put into place before the storm hits to meet both the short-term goals of salvage and fire prevention and the long-term goal of reforestation and ecological recovery." Stanturf and fellow authors use the case stu...

Are scientists making progress in being able to regenerate bone tissue?

...y has been the number one choice for attempting to restore function. But there are major problems with such grafts—for example, removing bone from a different part of the body can lead to post-operative pain, infection, and abnormal sensations at the removal site. An alternative is to use bone given by a d...

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