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Tag: "responses" at biology news

Depression model leaves mice with molecular scar

... source of vulnerability to future depression-like responses to stress. Imipramine reversed the suppressed BDNF gene expression by triggering a compensatory mechanism, acetylation, in which molecular activators attach themselves to the gene and overcome the silencer molecules. Imipramine turned off an enzyme...

Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool

... cells normally divide (the cell cycle) and immune responses to disease and infection. "Ultimately, we think that the addition of this method to standard DNA microarray analysis will make it more accurate and cost-effective," Bar-Joseph added. "While DNA microarrays are very powerful, they present a sampling...

The reason why antiviral therapy can't annihilate HIV infection, and what to do about it

...ted, most likely as a result of normal immunologic responses to various antigens and cytokines. In turn, virions released during the reactivation process may spread to neighboring resting as well as activated CD4+ T cells; direct cell-to-cell spread in the absence of virion release may also occur. The study ...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

...rs) criteria ?a group of standards used to measure responses to treatment in solid tumors. Of the 65 evaluable patients, 10 partial responses were confirmed at the 4th cycle assessment. Twenty-one patients had stable disease (SD). In treatmen...

Langerhans cells regulate immune reactions in the skin

... required and, in fact, inhibit or modulate immune responses in the skin. Daniel H. Kaplan, M.D., and Mark J. ...ans cells are thus not required to generate immune responses in the skin and more profoundly, they actually regulate immune responses in the skin." According to...

Phenolic compounds may explain Mediterranean diet benefits

...earchers used Doppler laser to measure endothelial responses to sudden changes in blood flow, which were produced by inflating and then deflating a blood pressure cuff. The response is known as ischemic reactive hyperemia. Poor responsiveness to this sort of blood flow test is considered an early warning sign ...

New malaria vaccine shows promise in early clinical trial

...g, specific, and in some cases long-lasting immune responses against the MSP3 protein. However, as researche...ials, the crucial question is whether these immune responses mean that vaccinated people are actually protected against malaria. The straightforward way to test ...

The brain is broadly wired for reproduction

...al stimulus. They found that pheromones triggered responses in neurons upstream of GnRH neurons in both odor and pheromone relay areas. "This suggests that there is a redundancy in pheromone detection, with at least some pheromone information being conveyed by both the main and accessory systems," said Buck. ...

Cancer support cells may evolve, fuel tumor growth, study shows

...tanding the signals, their pathways and the cells' responses was needed. They said their findings underscore the dynamic complexity of cell-to-cell interactions and the changing selective microenvironment that drives cancer development. ...

Algal protein in worm neurons allows remote control of behavior by light

...chers have been able to elicit specific behavioral responses by simply illuminating animals with blue light. The work paves the way for better understanding of how neurons communicate with each other, and with muscles, to regulate behavior in intact, living organisms. Generally speaking, detailed information a...

Cord blood cells may widen treatment window for stroke

...tudy to determine the timing of brain inflammatory responses in acute stroke patients. Researchers working with Dr. Willing were Jennifer Newcomb, Ted Ajmo, Lisa Collier, Cyndy Davis Sanberg, PhD; Keith Pennypacker, PhD; and Paul R. Sanberg, PhD, DSc. The USF study was conducted with Saneron CCEL Therapeutics...

Federal grant funds research on novel HIV therapy

...animal model experiments to establish pharmacology responses and the human trials designed to assess safety and activity. The basic science projects of this four-year grant are already providing data, building on existing investigations of NK-1R antagonists. The animal model studies and clinical trials are i...

Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method

...sts and clinicians better evaluate specific immune responses to disease, making diagnosis and treatment more pr...ective makes it possible to see critical ancillary responses in addition to the specific cellular battles of the immune system at the site of a tumor, for exampl...

PET imaging reveals the immune system at work

...sts and clinicians better evaluate specific immune responses to disease, making diagnosis and treatment more pr...ective makes it possible to see critical ancillary responses in addition to the specific cellular battles of the immune system at the site of a tumor, for exampl...

The dangerous legacy of lead

...oid suppressor cells, which control runaway immune responses ?may also be disrupted by lead exposure in mice. The next step is to understand how this applies to humans. Already, scientists know that lead is toxic to the nervous system and certain regions of the brain. This latest research underscores the burd...

Neurons generated in the adult brain learn to respond to novel stimuli

...y responding to those smells. "These contrasting responses suggest that adult-born olfactory neurons have a unique role in the brain, becoming linked to new smells while the older neurons essentially step out of the way. And since adult-born neurons are continually being generated, there is always a group o...

Brain activity related to processing faces is similar in people with, without autism

...gh complex information, selecting task-appropriate responses or inhibiting inappropriate ones, take place. "In other words, these tasks require high levels of cognitive control," Belger said. "We wanted to find out if these executive functions of particular brain regions that are critical for the appropriate ...

Plants have a double line of defence

...chers in Cologne have now shown that active immune responses make a key contribution to nonhost resistance ?for example, the transport of PEN2 to the place of infection. In further studies, the researchers hope to try to identify materials that are built up via PEN2 at the place of infection. They surmise tha...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

... time, and might also be used to monitor treatment responses in breast cancer patients. The approach might be useful for other cancers, such as colon, lung, and ovarian, as well as for melanoma and non-Hodgkin's lymphoma. The next step is to design a more efficient complex. "Right now we saturated the nanop...

Male elephants woo females with precise chemistry

... that alterations in those ratios elicit different responses in not only female elephants, but also other male ...with its easily observable and countable olfactory responses involving its trunk. We can't do this in any other mammalian species." Rasmussen added: "All of the...

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