Hirsute Or Hairless? Two Proteins May Spell The Difference
...analyze the timing of external signals against the response of targeted cells to determine how targeted cells translate signals into changes in cell adhesion and remodeling, proliferation, and differentiation—the agents of most types of organogenesis. Since Snail, a protein that impedes the transcription of ...Programmable cells: Engineer turns bacteria into living computers
...bacteria to emit red or green fluorescent light in response to a signal emitted from another set of E. coli. In one experiment, the cells glowed green when they sensed a higher concentration of the signal chemical and red when they sensed a lower concentration. In a Petri dish, they formed a bull's-eye patter...Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients
...portion of patients show a reduced response, or no response at all. Given the variability of the disease and t...nal model that can predict a patient's therapeutic response to interferon based on their gene expression profiles. Immune cells typically secrete interferons t...PET/MRI scans may help unravel mechanisms of prenatal drug damage
...nique that could also be used to monitor a fetus's response to therapeutic drugs--using sophisticated, noninvasive medical imaging tools. Scientists at the U.S. Department of Energy's Brookhaven National Laboratory, whose findings are reported in the February issue of the Society of Nuclear Medicine's Journal...Chemists identify immune system mechanism for methamphetamine binges
...s to it. "Antibodies are usually produced only in response to large molecule invaders such as proteins, not t...lerance refers to the capacity to have a decreased response to a drug after prolonged use. Increased drug tolerance raises the likelihood that a person will bec...HIV vaccine trial breaks ground for future research
...hors suggest that biological differences in immune response or genetic markers of resistance to infection coul...participants, and, in general, those with a higher response had a lower rate of infection than the placebo group. In an editorial accompanying the two papers, B...Robot-based system developed at Carnegie Mellon detects life in Chile's Atacama desert
... in 2005. Zoë, a brand new robot, was developed in response to what was learned in 2003. In the final year of the project, plans call for Zoë, equipped with a full array of scientific instruments, to operate autonomously as it travels 50 kilometers over a two-month period. The science team, led by Cabrol, is...Discovery Promises Simpler Therapy for Sickle Cell Disease
...o constrict when oxygen levels drop, they found, a response which would further exacerbate the oxygen deficiency. Treatment of red blood cells with nitric oxide reversed that effect, they reported. "Our results suggest that abnormal blood vessel control by red blood cells contributes to the vessel obstructio...Researchers discover chemical compounds that affect plant growth
...ty of plants to alter their direction of growth in response to gravity, a phenomenon known as gravitropism. The researchers screened a library of 10,000 small molecules, the practice is known as chemical genomics, to identify those that could positively or negatively affect gravity's effect on plant growth, ...Stem cells from brain transformed to produce insulin at Stanford
...cells that could produce insulin and release it in response to sugar added to the environment. These cells don't perfectly mimic human islet cells. Kim's cells made some, but not all, proteins normally made by islet cells, and they continued to make some proteins found in neurons. Nonetheless, the fact that ...New component of the 'brakes' on nerve regeneration found
...nfunctional version of TAJ/TROY abolished neurons' response to the "braking" molecules produced by myelin and ...eficial to regeneration or recovery--in regulating response to injury. "Further characterization of the underlying mechanisms of these findings and their relati...Scientists discover how plants disarm the toxic effects of excessive sunlight
...tself from this toxic substance. He notes that the response mechanism is likely highly conserved across species from microbes to plants and humans - and therefore very applicable to other fields of study. For example, too much sunlight can actually be harmful to plants, because the heightened photosynthetic ...Gene Therapy Cures Inherited Liver Disease In Rats
...see one developed that minimizes the body's immune response to it immediately right after it is injected into the body. "Fifteen years ago, the goal was to get some correction of the problem," he said. "Most effects were transient. Now with these vectors, long-term correction with no long-term toxicity is po...Multi-purpose protein regulates new protein synthesis and immune cell development
...o acids, which are deposited in the ER membrane in response to coded instructions from genes. Chaperone protei...vent this, the cell activates the unfolded protein response (UPR). "The UPR has three main aspects," Kaufman explains. "First, it signals the nucleus to stop s...Light therapy may combat fungal infections, new evidence suggests
...C2, that is also required for C. neoformans normal response to both blue and ultraviolet light. Moreover, the researchers found, mice inoculated with C. neoformans lacking either of the light-sensing genes remained healthy 30 days later, while those infected with the normal fungus died by day 30. The findin...Computational Method Speeds Mapping of Cell Signaling Networks
... to perform a variety of tasks--such as growing in response to hormones, moving towards a source of nutrients,...ere along the pathway T-cell components changed in response to signals. An increase in the amount of the molecules indicated spots where they were most active. ...Marburg haemorrhagic fever in Angola update
...il. Assessment of the outbreak The international response to the outbreak in Angola began one month ago, on ... the Ministry of Health in Angola. The operational response began the following day. As known from extensive experience with outbreaks of other viral haemorrhag...Microbial forensics: The next great forensic challenge
...and has been a leader in this area of our national response since then. "An effective program requires relevant, exploitative, fully validated methods and uses in all aspects of the forensic investigative process," Murch said. "This ranges from sample collection to interpretation of results, while achieving ...Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
...consequences." Diverse emotions occur, but reward response primary "It's a stark reminder that the mind trul...ed, "even love-at-first-sight is a basic mammalian response that developed in other animals and our ancestors inherited in order to speed up the mating process....Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
...lls found in leukemia from undergoing apoptosis in response to chemotherapy or radiation. This makes the leukemia cells resistant to treatments designed to damage the cell so it undergoes apoptosis." Opferman is continuing his studies of Mcl-1 at St. Jude to better understand the role this protein plays in bo...