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Tag: "response" at biology news

NIAID Initiates Trial of Experimental Avian Flu Vaccine

...vaccine’s safety and ability to generate an immune response in 450 healthy adults aged 18 to 64. If the vaccine is shown to be safe in adults, there are plans to test it in other populations, such as the elderly and children. H5N1 avian influenza leads to severe disease in both birds and humans. Between Janu...

First real-time view of developing neurons reveals surprises, say Stanford researchers

... They expected to find that young neurons fire in response to a variety of different images, then refine their role over time so that in the adult fish the neurons only respond to images moving in a certain direction or near the left or right side of the visual field. What they found was a surprise. As soon...

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

...for androgens, the malehormone, can proliferate in response to BPA.“The results may have implications for men ...cell growth.“The results we see in cell culture in response to BPA are ready to bemoved to appropriate animal models next,?said Dr. Knudsen. The effectof the en...

The Bacteria's guide to survival

...e already known to regulate apoptosis and cellular response to stress, including mechanical strain on the membrane. Also, a majority of these genes were known to be induced by a family of proteins called mitogen-activated protein kinases, or MAPKs. The researchers showed that blocking MAPKs reduced the activi...

Influenza vaccine uses insect cells to speed development

...e virus, called hemagglutinin, to elicit an immune response against that specific strain of the virus. Wang a...safety and the ability to elicit a strong antibody response in humans. "Since all the media used here are chemically stable and commercially available, the pro...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...reduces the cell's ability to trigger apoptosis in response to relentless prodding by MYC to keep multiplying....nsisted of a complete elimination of the apoptotic response through loss of p53 function," Grosveld said. "In fact, all TEL2/MYC B-cell lymphomas had lost their...

Scientists solve structure of key protein in innate immune response

... proteins which initiate a strong pro-inflammatory response that stimulates host defenses. "Macrophages and monocytes can recognize distinct structural patterns in various molecules from pathogenic microorganisms," explains Dr. Jie-Oh Lee of the Korea Advanced Institute of Science and Technology. "LPS is the...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

...dicting disease susceptibility and an individual's response to drugs," said Patrick Kelly, European Site Manager and Vice President, Affymetrix. "This is what personalized medicine is all about -- enabling clinicians to detect diseases earlier and manage them more effectively. We are excited about the potenti...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

...l treatments; even after patients initially have a response to treatment, the disease almost always comes back and becomes more difficult to treat. Bexxar, whose chemical name is tositumomab and iodine I 131 tositumomab, combines an antibody that seeks out cancer cells, and a radioactive form of the element ...

World's largest rainforest drying experiment completes first phase

...drying, it is important to understand the forest's response to this scenario nonetheless. What types of trees will invade the forest that has now been "released" from its imposed drought? And are the trees that survived somehow damaged, and unable to respond to this release? Have the vessels that conduct wate...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...ecular basis for genetic differences in behavioral response to alcohol and may eventually lead to new therapeutic approaches for alcoholism," said Michael Miles, M.D., Ph.D., a professor in pharmacology, toxicology and neurology, who also has an appointment in VCU Life Sciences' Center for the Study of Biolog...

Sequencing of marine bacterium will help study of cell communication

...a bacterium changes its gene expression pattern in response to quorum sensing," she said. The genome sequence has allowed Stevens to begin exploring the connection between quorum sensing and other global regulatory networks through a combination of comparative genomics and experimental molecular biology. Oth...

International HapMap consortium expands mapping effort

...se, genetic variation has been shown to affect the response of people to therapeutic drugs, toxic substances and environmental factors, and the HapMap can assist in the identification of those variants. Since not all genetic variants are deleterious, the HapMap also may be used to help to pinpoint genetic var...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...roadly protective antibodies have not been made in response to currently tested HIV vaccines," said Barton Hay...tem category is adaptive B cell immunity, a slower response that creates powerful, pathogen-specific antibodies and provides lasting immunity. The body's normal...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...of the immune response. Because it spurs an immune response without live bacteria, LPS helps to reveal how the... these cytokines, or certain protein molecules, in response to germs. Prior research had suggested that higher IL-1BETA in the brain's hippocampus, a key memory...

Effective Cancer Treatments Follow The Clock

...asured the animals' body weight as an indicator of response to the anti-cancer drug. They discovered that Clock-mutant and Bmal1-knockout mice showed high sensitivity to the drug at any time it was administered ?as if the drug were administered early in the morning or late at night. In contrast, the Cryptochr...

Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy

...vant, a compound that stimulates the immunological response to a vaccine, which is essentially tricking the im... LICR Lausanne Branch. "The immune system mounts a response against the peptide antigen, the cancer-specific target, in the vaccine, and thus also against the a...

Yale researchers identify molecule for detecting parasitic infection in humans

...the parasite components that trigger a host immune response may facilitate the development of better vaccines." ...

NYU study reveals how brain's immune system fights viral encephalitis

...show the redundancy of the immune system--when one response fails to fight infection, others step in." The st...ns--proteins made by the body that are released in response to stimuli, notably infection--work in neurons and to determine if nerve cells' response to interfer...

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

...nd disease processes to drug development and early response to anticancer and gene therapy. In addition, small animal imaging significantly reduces the preclinical evaluation time for therapeutic pharmaceuticals, possibly speeding the way for innovative drugs to patients, said Welch. Since there is no public ...

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