How does Mycobacterium tuberculosis infect the lung?
... fight TB, a disease that is becoming increasingly resistant to existing therapies and for which new drugs are urgently needed. ...Compound from marine bacteria shows potential as multiple myeloma therapy
...d nerve pain. In some patients, the disease can be resistant or become resistant to bortezomib. Because NPI-0052 and bortezomib attack the same intracellular target in different wa...Genetic defenders protect crops from fungal disease
...ts use genes to fight infection. "Most plants are resistant to the majority of pathogens they encounter, but the basis for this resistance was unknown," Somerville said. "Identifying these genes has provided us with the first insight into how plants defend against multiple pathogens." Once a powdery mildew i...New technique multiplies life span in simple organisms
... hit them with heat," Longo said. "They are highly resistant to everything. What they're doing is basically saying, 'I cannot afford to age. I still have to generate offspring, but I don't have enough food to do it now." Longo predicted that as molecular geneticists master the levers of aging, they will be ab...Gene controls whether fear is a factor
...vival, memory for fear is easily established, very resistant to extinction, and normally lasts a lifetime, Shumyatsky said. In the laboratory, fear can be conditioned by linking a neutral stimulus, such as a light or sound, to something unpleasant or painful, such as an electric shock, he explained. That proc...HIV drug resistance increasing in UK and among highest in the world
...orld, prompting fears of a second wave epidemic of resistant virus, a new study claims in this week's BMJ. The...al drugs in total. Most of these people ?257 ?were resistant to drugs within one class only, 44 cases showed resistance to drugs within two classes and 34 showed...Plants have a double line of defence
...le to attack a plant, that means that the plant is resistant to it ?in other words, it cannot host the pathogen. This durable type of immunity of a plant to parasites is called nonhost resistance. Although, in nature, nonhost resistance stops almost all parasite attacks, it has been the subject of little rese...Plant gene related to cancer treatment may foster new oncology drugs
...the first time that proteins similar to multi-drug resistant proteins in humans move a plant growth hormone int...pe through something sticky." Both the multi-drug resistant PGPs in people and plants are part of a large family of proteins, called ATP-binding cassette (ABC) ......s ensure that the few pink bollworm moths that are resistant to Bt are most likely to mate with Bt-susceptible ... cotton, only pink bollworm caterpillars that were resistant to the Bt toxin would survive. If resistant pink bollworm moths mated with each other, their offspri...GM crop that holds on to its seeds offers higher yields
...s. Østergaard says that combining the new drought resistant varieties with his teams' plants that do not shatter their seeds could yield crops that are well suited for the warmer climates of most developing countries. Link to abstract of paper in Plant Biotechnology Journal Reference: Plant Biotechnolog...Researchers learn how blood vessel cells cope with their pressure-packed job
...cells that line arteries can make them healthy and resistant to vascular diseases. UCSD researchers stretched ...cells that line arteries can make them healthy and resistant to vascular diseases. Bioengineering researchers at UCSD's Jacobs School of Engineering will report...NC State researchers redesign life for Mars and beyond
... plants, we could potentially make the plants more resistant to extreme conditions such as drought and extreme temperatures that we have on Earth, but also to the extreme conditions that one might find on Mars." Now that the concept of inserting a single gene from an extremophile into a plant has been proven,...New antibody shows promise as cure for anthrax
...errorists might design a strain of anthrax that is resistant to antibiotics, but this antitoxin could eliminate those concerns by providing an effective treatment that doesn't require antibiotics." Anthrax infection is successfully treatable only in its early stages, when antibiotics can be used to kill anthr...Purdue researchers find key to rice blast fungus
...ial of being used to produce new fungicides or new resistant rice plants to hold this pathogen at bay. However, rice blast fungus is able to quickly evolve new tricks to tackle rice plants, apparently because the fungus and the grain developed side by side over centuries, according to genetic experts. To overc...Study findings offer potential new targets for antibiotics
... ahead of disease-causing bacteria that can become resistant to antibiotics. The secret lies in understanding the function of the ribosome, a tiny protein-making factory residing inside most cells. Many currently used antibiotics alter a ribosome's ability to make proteins, said Kurt Fredrick, a study co-aut...Drug resistant avian influenza viruses more common in Southeast Asia than North America
...o amantadine, while 16 percent of H7 isolates were resistant to this drug. "These data are clear and convincin...e on the M2 gene to acquire mutations that made it resistant to this antiviral drug. "H5N1 is now endemic-a permanent- resident- in Southeast Asia, including Ch...Metal-containing compounds show promise as HIV weapon
... be effective against HIV strains that have become resistant to that class. Dr. Pavlina Rezacova, postdoctoral researcher in biochemistry at UT Southwestern, also participated in the study, as did researchers from the Academy of Sciences of the Czech Republic; the Institute of Chemical Technology and Charle...Techniques available to detect soil that inhibits destructive soybean pest
...istance, including even plants that are bred to be resistant to the organisms." Westphal and his research team conducted a survey throughout Indiana to locate nematode-suppressive soils in an effort to make this tool more available and to further study the mechanisms that create its effectiveness against the ...UT Southwestern researchers discover master switch in cell death
...aking the tumor more likely to grow and perhaps be resistant to chemotherapy. Treatment might then focus on the biochemistry of Mule and Mcl-1, he said. “We might be able to see if there’s a problem with Mule, or perhaps we could screen beforehand,?Dr. Wang said. Other UT Southwestern researchers involved in...DDT-resistant insects have additional genetic advantage that helps resistance spread
...ed the study. "This suggests that by becoming DDT resistant the female flies are passing on some unknown advan...ves. "Experimenters looking at genetic fitness in resistant insects often only look at single character traits such as number of eggs laid, and often compare re...