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Scientists identify new model Of NK cell development

...ances ?T cells and dendritic cells ?just happen to reside in lymph nodes, too." Freud also makes the provocative observation that lymph nodes, while full of CD56 bright cells, are significantly lacking in their counterparts, the CD56 dim cells. "Our next goal is to determine if there is some developmental...

Researchers uncover sequence of major rice pathogen

...he toxin molecules," he says. Some of these genes reside in clusters, Dean says, so one focus will be to take apart the clusters and learn more about toxins and their production. "The primary mission is to uncover the organism's weaknesses. You do that by building up an arsenal of information of what gene...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

...of the genes already known to be involved in NSCLC reside within the abnormal regions identified by the Dana-Farber team. "This is compelling evidence that we're on the right track," says the study's other first author, Kwok-Kin Wong, MD, PhD, of Dana-Farber. "It's likely that the genetic mutations already...

Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

...en before. The key to Orf2’s flexibility seems to reside in the active site, the region of the enzyme where the small aromatic molecules bind. In many enzymes, the structure of the active site only allows one specific molecule to interact with it, like a key fitting into a lock. But the scientists found th...

Stem cell training program to make its Stanford debut

...en before. The key to Orf2’s flexibility seems to reside in the active site, the region of the enzyme where the small aromatic molecules bind. In many enzymes, the structure of the active site only allows one specific molecule to interact with it, like a key fitting into a lock. But the scientists found th...

Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors

...ry demonstrates for the first time that stem cells reside in the cerebellum and provides us with a starting point for identifying the cells and genes involved in many medulloblastomas." The researchers hypothesize that tumors could arise when stem cells in the cerebellum become inappropriately activated an...

Bitter or sweet? The same taste bud can tell the difference

... differentiate between sweet and bitter tastes may reside in the same taste bud cells, a new study reports. The study explains the discovery of a chemical messenger called neuropeptide Y (NPY) in taste bud cells. Though researchers have long known that NPY is active in the brain and gut, this is the first ...

Engineered skin offers clues to melanoma development

...nocytes, the pigment-producing cells that normally reside in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a sample of human skin that was grafted onto laboratory mice. The mice were observed for u...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...nocytes, the pigment-producing cells that normally reside in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a sample of human skin that was grafted onto laboratory mice. The mice were observed for u...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...nocytes, the pigment-producing cells that normally reside in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a sample of human skin that was grafted onto laboratory mice. The mice were observed for u...

Modification of program enables prediction of gene transcription

...s. Some of the signals that regulate transcription reside right near the transcription site. There is a huge amount of biology to be discovered there, and the appreciation of this area is growing daily." While genomics researchers 15 years ago paid little attention to parts of the genome outside the coding...

Study hints at role of stem cell genes in testicular, breast cancers

...ts, in fact, that genes in adult stem cells ?which reside in many tissues of the body ?cause some leukemias, and that they may cause gliomas, the most common form of brain tumor (UCSF - Nature, Feb. 19, 2004 ; UCSF - New England Journal of Medicine, Aug. 25, 2005). The current study evolved from ongoing re...

Islands in the Genome Promote Speciation

...ture work focusing on the 67 genes hypothesized to reside in the divergent regions should yield interesting clues to the identity of genes that drive speciation, and the mechanism by which they do so. This is a significant finding in the field of speciation research: in terms of methodology, this study sho...

Adult stem cells aid recovery in animal model of cerebral palsy

...ture work focusing on the 67 genes hypothesized to reside in the divergent regions should yield interesting clues to the identity of genes that drive speciation, and the mechanism by which they do so. This is a significant finding in the field of speciation research: in terms of methodology, this study sho...

Finding the mind's eye

...f the brain related to visual perception appear to reside exclusively in the occipital lobe (at the back of the head.) Tse's team concluded that, "the neural correlates of conscious visual visibility for masking stimuli lie in the occipital lobe, but after visual area 2." ...

Scientists develop protein-sequence analysis tool

...e -- it can be applied to studies of proteins that reside in the cell membrane, for which it is notoriously difficult to determine a molecular structure. ...

'Accelerated evolution' converts RNA enzyme to DNA enzyme in vitro

...information and catalytic function were thought to reside only in RNA. In our study, the evolutionary transition from an RNA to a DNA enzyme represents a genuine change, rather than a simple expansion, of the chemical basis for catalytic function. This means that similar evolutionary pathways may exist betw...

Clues to breast cancer hidden inside stem cells

...Perhaps it is not surprising then, that stem cells reside in this compartment. In 2002, Thorarinn Gudjonsson, successfully isolated cells from the human breast with stem cell properties. Gudjonsson immortalised these cells and grew them in three dimensional matrix that mimics the real, living tissue. Biol...

Cancer cells suppress large regions of DNA by a reversible process that can be tackled

...What we've found is that non-methylated genes that reside in a particular suburb near methylated genes are also silenced. Their physical proximity to the methylated genes affects their ability to function. It's a case of being in the wrong neighbourhood at the wrong time", says Assoc. Professor Clark. The ...

Novel molecular 'signature' marks DNA of embryonic stem cells

...cting the dual nature of its design. These domains reside in the sections of chromatin that control the most evolutionarily conserved portions of DNA, particularly the key regulatory genes for embryonic development. "These signatures appear frequently in ES cells, but largely disappear once the cells choos...

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