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Tag: "researchers" at biology news

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...ll. In the Feb. 24 online version of Science, the researchers report that mice engineered to have a double dose ... many tumors as those with normal IGF2 levels, the researchers report. "Both clinically and scientifically, this discovery should expand attention in colon cancer...

Columbia research lifts major hurdle to gene therapy for cancer

...ngs of theNational Academy of Sciences (PNAS), the researchers demonstrated thatthe technique works by incorporat...ed on two moleculescalled PEA-3 and AP-1 that, the researchers found, are usually abundantinside cancer cells. Both of the molecules flip a switch (called PEG)that...

Dysentery uses 'sword and shield' to cause infection

...lecule that acts as a shield on its surface." The researchers found that shigella, the bacteria causing dysentery uses a Type III secretion system to inject proteins into human cells. This causes the cells to become inflamed, resulting in symptoms of dysentery, such as bloody diarrhoea. At the same time, the LP...

Topical treatment shown to inhibit HIV and herpes simplex virus infection

Mount Sinai School of Medicine researchers demonstrated that a gel applied in the vagina prov...ays a major role in the sexual spread of HIV. The researchers conducted a prospective, randomized, double blind, placebo-controlled study among 20 HIV-infected wo...

Priming embryonic stem cells to fulfill their promise

Bioengineering researchers at the Universityof California, San Diego have inv...standardized laboratory machinery. "We think other researchers couldeasily use this technique with any other tissue in mouse, or human, orany other species," said ...

Growth in the sea comes down to a struggle for iron

...destination in mind. Work by Japanese and Canadian researchers has already shown that the consequences of iron additions may vary from the eastern to the western North Pacific. Even with additional iron, large phytoplankton cells in the east do not appear to grow as readily. Since prevailing winds tend to blow i...

New, automated tool successfully classifies and relates proteins in unprecedented way

For the first time, researchers haveautomatically grouped fluorescently tagged proteins fromhigh-resolution images of cells. This technical feat opens a new way toidentify disease proteins and drug targets by helping to show whichproteins cluster together inside a cell.The approach...

New binding target for oncogenic viral protein

... published in the Journal of Biological Chemistry, researchers at the Fred Hutchinson Cancer Research Center report the discovery of an additional target for T antigen--a protein called Fbw7. The Fbw7 gene is located in a chromosomal region that is deleted in up to 30% of human tumors. "Fbw7 is itself an import...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

... 2 diabetes later in life. In studies of mice, the researchers found that poor prenatal nutrition impairs the pan...ng type 2 diabetes. To understand the reason, the researchers designed a series of experiments. Using ordinary mice that were not inbred or genetically altered in...

Controversial drug shown to act on brain protein to cut alcohol use

...ears afterbreaking the habit.In this analysis, the researchers provided alcohol to rats until theyhad become "experienced" daily drinkers. They then withheld alcohol fortwo weeks, which normally leads to greatly increased drinking when whenalcohol is again available. When they administered Ibogaine, they foundth...

Neuronal 'traffic jam' marks early Alzheimer's disease

... human brain samples from people with the disease, researchers observed a characteristic breakdown in neurons tha... leading to their failure and eventual death. The researchers said their findings could provide information that might be used to develop drugs to preserve the mo...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...anuary 23, 2005 in the journal NatureMedicine, the researchers found that human embryonic stem cells,including th...do not expressNeu5Gc*. In a 2003 study**, the UCSD researchers found that humans havenaturally occurring antibodies that are directed against Neu5Gc. In thecurrent...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

...of the referenced documents in the ads. However, researchers could only obtain 20 percent of the data-on-file d...erence documents, 99 percent were available. UCLA researchers also checked the funding sources of the original research cited in all the ads and of a random sampl...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...ody for years at a time. Such information may help researchers find better means to harness the immune system to ...ientists say the E. histolytica sequence will help researchers develop new tools to predict which of the millions of people who ingest amoeba cysts in contaminated...

Anti-bacterial additive widespread in U.S. waterways

...lf a century, according to ananalysis conducted by researchers at the Johns Hopkins Bloomberg Schoolof Public Hea...a on the environmentaloccurrence of triclosan, the researchers predicted triclocarbanconcentrations for 85 U.S. streams. The study results suggest that theantimicr...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...r therapies that involve tissue regeneration. The researchers found that Pax3, a gene critical in embryonic development of melanocytes ?cells that make and store the pigments in the skin and hair ?is also expressed in adult stem cells in the skin. "Our findings told us that a recapitulation of an embryonic pro...

Timing is everything: First step in protein building revealed

... begin."To monitor what was happening to eIF1, the researchers tagged it and arelated part of the ribosome with d... the color of the emitted light changesas well.The researchers successfully used this phenomenon, known asfluorescence resonance energy transfer or FRET, to monito...

Plants, animals share molecular growth mechanisms

...ions involved in this process eventually may allow researchers to design plants better able to protect themselves...laments are askew and causing altered growth. The researchers previously had learned that a large protein complex, known as WAVE, activated ARP2/3, but they didn'...

Researchers Uncover Key Step In Manufacture of Memory Protein

...eeded for long-term memory, according to a team of researchers led by scientists at the National Institute of Chi...factor. In an earlier study, another team of NICHD researchers had shown that mBDNF is essential for the formation of long-term memory, the ability to remember thi...

Plants respond similarly to signals from friends, enemies

...n Proceedings of the National Academy of Sciences, researchers at North Carolina State University have found that...onal study in living cells over time, the NC State researchers discovered that the model legume Lotus japonicus responded similarly to signals from both rhizobia, ...

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