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Tag: "required" at biology news

New drug shows promise as powerful anticancer agent

... block the function of a critical molecule that is required by a tumor cell to complete cell division," explains lead author Dr. E. Premkumar Reddy from Temple University School of Medicine. "One such molecule appears to be Plk1." Dr. Reddy and colleagues examined the effects of Plk1 inhibitor ON01910 on tum...

Microbial forensics: The next great forensic challenge

...ient, but rather a 'multivariate approach' will be required that is tailored to the threat encountered and situation to be addressed. In any case, the scientific and investigative processes must be closely coupled and mutually supportive," Murch said. There have been numerous national responses to bioterrori...

Researchers uncover sequence of major rice pathogen

... his co-authors shed some light on the adaptations required by a fungus to cause disease. The researchers iden... gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, inclu...

Some Brain Cells 'Change Channels' To Fine-tune The Message

...etermined that the PICK1 and NSF proteins are both required for the calcium-forbidding channel to move into place at the synapse. Exactly how they help the channels move is still unknown, as is why the cells change their channels. Part of the answer is likely to be self-preservation: Too much calcium inside ...

Same-Sex Mating Discovered in a Toxic Fungus

...rmore, the team showed, strains lacking components required for mating -- including pheromones, pheromone receptors and other genes with known roles in mating -- exhibited a defect in fruiting. The newly described mating strategy might allow a single mating strain to expand rapidly by cell division, yet reta...

Medical whistleblowers speak out

...less they have to - meaning basically that they're required by a regulator - and that rarely happens." The industry researcher explained that the studies that are the basis for regulatory approval are too small and are conducted over too brief a period to properly assess safety. There are "blockbuster drugs"...

Study reveals new technique for fingerprinting environmental samples

...genome's worth of data to understand the functions required of the organisms living in a particular setting. Rather, the genes present and their abundances in the EGT data reflect the demands of the setting and, accordingly, can tell us about what's happening in an environment without knowing the identities o...

A puzzle piece found in unraveling the wiring of the brain

...hta and Hiesinger found a gene named sec15 that is required for nerve cells to make appropriate choices of tar...protein complex (the exocyst) which is known to be required for secretion (or exocytosis) of vesicular compartments in yeast. Vesicular compartments are small o...

New tumor-suppressor gene discovered

...al experiments also revealed that the mats gene is required for normal differentiation of eye cells during the development of the fly's eye. Lai's team also tackled the tough challenge of discovering how the mats gene is able to suppress the growth of tumors. "We did not find many clues when we compared the ...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...to facilitate the degradation and that microRNA is required as well. They believe that the microRNA and protein form a large complex of molecules, though they do not know exactly how many proteins and other molecules are involved. The article, "Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instabi...

Shutting down the HIV assembly line

... important part in that each step along the way is required to make an infectious viral particle." Spearman's team has focused on a protein called "Gag," the major HIV structural protein. In recent years, Spearman said, it has become apparent that Gag moves to a compartment in the cell called the multivesicu...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

...or more specificity and potency so as to lower the required dose for efficacy." The study was a collaborative effort between the laboratory of Timothy J. Triche, at Children's Hospital of Los Angeles; and the laboratory of Mark E. Davis, at the Caltech. Also participating in the study were Jeremy D. Heidel a...

Protein helps regulate the genes of embryonic stem cells

...In the study, eed is the first protein shown to be required for the addition of a single methyl group to histo...irth defects, he added. The discovery that eed is required to modify histone H3 in a unique way opens up new lines of investigation into the role eed might pla...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

...on." The structure reveals a "pseudoknot" that is required for telomerase activity, at whose core three strands of RNA come together to form a triple helix. All vertebrate animals investigated so far have nearly the identical sequence of nucleotides through the triple helix, Theimer said. "The triple helical...

Marine sponge yields nanoscale secrets

... incompatible with the high electronic performance required for today's device applications. Instead, the scientists expect that by learning the fundamental mechanism used in nature, that mechanism could be translated into a practical and low-cost manufacturing method. Such a "biomimetic" approach will event...

Study reveals candidate targets for anti-retroviral therapeutics

... antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a potential source of such novel targets, but relatively few appropriate target genes have been identified in animal cells thus far. A new study, conducted by Dr. Suzanne Sandmeyer and colleagues at the Universit...

Disease progression model of pancreatic cancer developed by Penn researchers

...ingorani. "In trying to understand what events are required to create and support invasive and metastatic disease, we hope to translate our findings into better therapies," states Hingorani. The study was funded in part by the National Institutes of Health, the National Cancer Institute, the National Pancrea...

Researchers make surprise discovery that some neurons can transmit three signals at once

...ey be able to depolarize a cell, both of which are required for NMDA receptor activation. But, as if by design, during the exact period when the auditory brain is undergoing refinement, the GABA and glycine neurotransmitters can produce depolarizations, a process that normally can only be achieved by excitato...

Master gene controls healing of skin in fruit flies and mammals

.... "The discovery that grainyhead-like factors are required for the response to injury opens up new avenues of research in the field of wound healing," said Kimberly Mace, the first author of the UCSD paper. "It also opens new avenues for cancer research, since many cancer cells activate genes normally involv...

Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics

...e solution. According to Lindsay, the solution is required to make the process work because, without it, the initial insulating property of the molecule prevents the first electron from ever jumping on to the molecule, a kind of “Catch-22.?Ions in the solution “jiggle?the molecule enough to bring about an un...

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