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Tag: "repression" at biology news

'Insulator' helps silence genes in dormant herpes virus

... a gene from being influenced by the activation or repression of its neighbors. About a dozen different insulator elements have been identified in organisms as varied as yeast, fruit flies, and humans. Not simply passive barriers, insulators help organize and regulate gene activity by marking boundaries on c...

Reactivated gene shrinks tumors

...provides critical genetic evidence that continuous repression of a tumor suppressor gene is required for a tumor to survive," said Andrea Ventura, an Italian postdoctoral associate in the Center for Cancer Research and first author of the paper. In normal cells, p53 controls the cell cycle. In other words, w...

Novel regulatory mechanism identified for key tumor suppressor p53

...ve identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans. The new molecular pathway described in the study suggests intriguing approaches to diagnosing or intervening in the progression of many types of can...

miRNA-mediated silencing of mRNAs

...ression by at least two independent mechanisms: by repression of translation and/or by induction of mRNA degradation. This provides an explanation for changes in mRNA levels observed at least for a subset of miRNA targets." ...

Salk scientists get to the root of plant cell fate

... is produced," he explains. Since transcriptional repression plays such a key role in animal embryonic development, the finding that a co-repressor controls polarity in plants was surprising, says Long. "We thought that because plants and animals are believed to have largely developed independently from each o...

Study identifies new role for breast cancer susceptibility gene

... repressor, ZBRK1, released the gene for ANG1 from repression and promoted survival of neighboring blood vessel cells and formation of capillary-like structures. Further studies demonstrated that mouse mammary tumors deficient in BRCA1 display high levels of ANG1 expression, prominent vascularization, and accel...

Researchers map out networks that determine cell fate

...press macrophage counterparts. Such counteracting repression circuitry may be the key to understanding stem cell regulation in general, Singh said. "We think that if this property of mixed lineage transcriptional priming is shared amongst different kinds of stem cells, then resolving these mixed-lineage states...

Researchers discover new form of cancer gene regulation

...r events, these signals trigger gene activation or repression through action of transcription factors in the nucleus of the cell. The altered gene expression profile then results in cellular differentiation, cellular proliferation or cellular death as pattern formation proceeds. An important signal transduc...

Limiting the damage in stroke

...dditional mouse models, which allow the reversible repression or activation of IKK2 at any time in neurons. "The unique advantage of this system is that we can specifically induce or block this signaling pathway at virtually any time and selectively in neurons," Wirth emphasizes. Putting all of this expertise...

Signs of aging: Scientists evaluate genes associated with longevity

...ced age. "We speculate that the apparent metabolic repression in early and mid-life adults contributes substantially to the observed longevity of daf-2," says Dr. Julius Halaschek-Wiener, a researcher at the BC Cancer Agency's Genome Sciences Centre and first author on the study. Another notable observation wa...

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