Marine sponge yields nanoscale secrets
...d how this glass is made biologically." The newly reported research describes an important step forward in tr...micals requiring costly remediation. Although the reported research marks an important step forward, Morse believes that the use of these biological methods to...NIAID begins clinical trial of West Nile virus vaccine
...ningitis. In 2004, 2,470 cases of WNV disease were reported in the United States, resulting in 88 deaths. Currently, no WNV vaccine is licensed for use in humans. The experimental vaccine is composed of a small, circular piece of DNA--called a DNA plasmid--that contains genes that code for two key surface pr...UCSD research reveals mechanism involved with type of fatal epilepsy
...tration of the protein laforin. These findings are reported in the current issue of Proceedings of the National Academy of Sciences (PNAS). Lafora disease is characterized by normal development for the first decade of life, followed by an initial seizure in the second decade, progressively worsening seizures...Protein prevents detrimental immune effects of bacterial sepsis
...fects of severe inflammatory response syndrome, as reported by researchers at Barts and the London, Queen Mary's School of Medicine and Dentistry. The paper by Damazo et al., "Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation," appears in the June issue of The A...Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
...ll division, Ueno and his colleagues have recently reported that increased activity of CDK1 correlated with a cell's sensitivity to Taxol. The CDK enzyme plays a role in cell division, and researchers believe that it functions in part as a monitor of cell cycle activity. Ueno theorizes that if something goes...Activation of thermoreceptors mediates raw garlic's burning pungency
...in thermoreceptors in the mouth. The findings are reported in the May 24 issue of Current Biology by a team led by Ardem Patapoutian of The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation. Despite garlic's popularity, the compounds responsible for its pungency, as w...Study reveals candidate targets for anti-retroviral therapeutics
...plication of a model retrovirus. Their results are reported in the May issue of Genome Research. Many organisms harbor mobile genetic elements that are non-pathogenic molecular relatives of retroviruses. In budding yeast, these mobile elements (called Ty ?or transposable yeast ?elements) encode proteins that...Signs of aging: Scientists evaluate genes associated with longevity
... as their wild-type counterparts. Daf-2 was first reported as a critical aging-associated gene in 1993, but since that time, scientists have identified dozens of additional genes that are crucial for longevity. "Aging is a complex process," explains Dr. Brooks-Wilson. "It is commonly believed that a variety ...After a time-shift, mixed signals from the circadian clock
...ght schedule at two different speeds. The work is reported in the May 24 issue of Current Biology by a research team led by Johanna H. Meijer of Leiden University Medical Center in The Netherlands. The researchers studied clock-resetting behavior in rats that were exposed to a six-hour delay of the light sc...The lopsided brain: Attention bias is shared by humans and birds
...le aspects of their environment. The findings are reported in the May 24 issue of Current Biology by Bettina Diekamp (now at Johns Hopkins University) and colleagues at Ruhr University, Bochum, Germany; the University of Padova, Italy; and The University of Trieste, Italy. It has been known for some time th...Supercomputers to focus brains on AIDS dilemma
...d bind to the integrase enzyme. The most recently reported of these simulations is in an article by Julie Schames, Richard Henchman, Jay Siegel, Christoph Sotriffer, Haihong Ni, and McCammon in the Journal of Medicinal Chemistry of April 8, 2004. These simulations revealed that a "trench" opens intermittentl...Basis for DNA ejection from single phage particles
...sure inside a bottle of champagne. In the new work reported this week, researchers have evaluated whether the energy thus stored is sufficient to permit phage DNA ejection, or only to initiate that process. The researchers used fluorescently labeled phage DNA to investigate in real time (and with a resolutio...Gladstone investigators discover how resting T cells avoid HIV infection
...rget of HIV -- to thwart the virus. The discovery, reported on April 13 in the online version of Nature, could open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology D...Conserved amino acids play both structural and mechanistic roles in sandwich-like protein
...rs at Rice University in Houston. This discovery, reported in today's issue of the Proceedings of the National Academy of Sciences, could benefit future research on treatments for diseases related to misfolded proteins, such as Alzheimer's and Huntington's. The Rice scientists studied azurin ?a copper-conta...Unchecked DNA replication drives earliest steps toward cancer
...otein called 53BP1, the critical role of which was reported by the same Wistar group in Nature last year, senses the DNA breaks caused by replication stress and activates the p53 pathway. That pathway shuts down the replication process, thus limiting further DNA damage. In some circumstances, p53 may even for...Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
...terials and Nanosystems.?The findings also will be reported in a forthcoming edition of the American Chemical Society’s journal Nano Letters. Lindsay’s team reports achieving an experimental result that physicists have been trying to detect for a long time: negative differential resistance in a single molecu...AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
... York City Department of Health and Mental Hygiene reported a highly resistant strain of rapidly progressive H...resident. The patient is a male in his mid-40s who reported multiple male sex partners and unprotected sex, often while using crystal methamphetamine. At the d...Important discovery about second most fatal cancer
.... The findings of Dr. Jass and his colleagues are reported in the March 2005 edition of Clinical Gastroenterology and Hepatology, published by the American Gastroenterological Association. ...Wake Forest scientists find new combination vaccine effective against plague
...t dangerous form of the plague ?pneumonic plague," reported Mizel, professor and chairman of the Department of Microbiology and Immunology at the School of Medicine, part of Wake Forest University Baptist Medical Center in Winston-Salem. Pneumonic plague occurs when an individual breathes in plague bacteria....Radio-tracking associated with 'dramatic shift' in water vole sex ratio
...er vole populations." Skewed sex ratios have been reported in stressed and malnourished females of various species, including water voles. The ecologists suggest this could be explained in terms of the local resource competition hypothesis, which predicts that mothers with access to poor resources will produ...