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Tag: "replication" at biology news

Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever

...it the human body's own defenses to increase their replication may be both a blessing and curse, according to the...t incomplete immunity to the virus. Enhanced virus replication triggers a more deadly, hemorrhagic form of the disease. A study published in the online edition o...

Plant wounds trigger bacteria

...ng to see whether those bacteria also increase the replication of the genes necessary for disease." The bacteriu...on of a protein called RepC, which is required for replication of the plasmid. The extra copies of this DNA enhance the ability of the bacterium to cause tumors, w...

HIV inserts into human genome using a DNA-associated protein

...s part of the cellular apparatus necessary for HIV replication is important to the field of gene therapy. Controlling where gene-therapy vehicles insert in the human genome could help make the delivery of new therapeutic sequences safer. The new findings about LEDGF suggest that engineered tethering interactions...

DNA size a crucial factor in genetic mutations, study finds

... not the usual size. ''The idea was to see how DNA replication depends on size,'' Kool says. The researchers investigated it by offering bases of different sizes to the DNA polymerase I enzyme and measuring how accurately the enzyme made new DNA copies. About once every 10,000 to 100,000 times the enzyme will p...

Hepatitis C complicated by morphine withdrawal

...wn using cell culture that morphine enhances virus replication and inhibits IFN-alpha (a natural anti-viral factor produced by immune, as well as host cells, and the only one approved in recombinant form for treating HCV infection). To further these results, his lab has used a cell model system to determine the...

Drug resistant avian influenza viruses more common in Southeast Asia than North America

...at after it enters a cell-an essential step in the replication of the virus. Amantadine inhibits the function of the M2 protein and thus stops viral replication. "By analyzing the sequence of the transmembrane part of the M2 gene we were able to determine how frequently amantadine resistance occurs in avian in...

Discarded placentas deliver researchers promising cells similar to embryonic stem cells

...cells do not share the same capacity for unlimited replication as do embryonic stem cells, they still can double in population size about 20 times over without needing another cell type serving as a feeder cell layer. This is significant, because to replicate, the currently available embryonic stem cell lines re...

Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases

... reproduce in a cell.Disrupting Rab9 prevented the replication of four different viruses ?Marburg, Ebola, HIV-1, and measles viruses. "We believe that interfering with the Rab9 pathway interferes with the ability of the viruses to exit the cell, thereby dramatically decreasing the ability of the virus to spread...

Life's origins were easier than was thought

...in length as they would not be able to correct the replication errors (mutations). Therefore they were unable to ...maximum number of errors that may occur during the replication process of ribozymes without this affecting its functioning, is higher than was previously calculate...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

...Murine Leukemia Virus, has since become capable of replication in their patients. "At the outset, our primary objective was proving the safety of gene therapy, especially for a clinical application to a nonlethal disease, such as arthritis. Once we learned of the adverse events in the X-SCID trial, we decided i...

Clearing jams in copy machinery

...h the correct proteins are retrieved to enable DNA replication in the face of DNA damage. The replication machinery inside the cell's nucleus is made up of a collection of enzymes including DNA polymerases,...

Columbia scientists develop cancer terminator viruses

...next generation of therapeutic viruses that permit replication uniquely in cancer cells with simultaneous production of immune modulating and toxic genes. These viruses effectively eliminate primary tumors and distant tumors (metastases) without harming normal cells or tissues. Dr. Fisher's cancer research team...

UIC developing drug for SARS

...ty of Illinois at Chicago shows promise in slowing replication of the virus responsible for severe acute respirat...uses AIDS. "Data from SARS patients indicate that replication of the virus peaks 10 days after the onset of fever," said Michael Johnson, director of the Center f...

Researchers create infectious hepatitis C virus in a test tube

...us particles that can infect new cells, initiating replication in them and leading to the production of more virus particles." Although little is know about the HCV life cycle, researchers think that in humans the virus enters a liver cell and delivers its RNA and proteins into the cell cytoplasm. HCV carries i...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...logical and psychiatric disorders as well. Such a replication would make viral-mediated gene therapy for brain diseases a reality." Dr. Paul Greengard, Nobel Laureate, Vincent Astor Professor and Head of the Laboratory of Molecular and Cellular Neuroscience at Rockefeller University, and Chairman of the Neurol...

Elevated temperature enhances success of viral cancer therapy

...5 is a mutated adenovirus that undergoes selective replication in tumor cells until the cells become so full of v...an Francisco examined why ONYX-015 did not undergo replication in some cancer cells and if it might be possible to sensitize tumor cells to ONYX-015 therapy. The ...

Novel mechanism for DNA replication discovered

...on and Francis Crick in 1953, the paradigm for DNA replication has stated that the DNA itself codes for the appropriate pairings for replication. In other words, if a guanine base is on the original strand of DNA then its partner, a cytosine base, will pair to it on the replicated strand. In a study published i...

USC researchers determine mechanism of action of chemotherapy drug

...n other words, thioredoxin reductase is key to the replication and survival of cells, and its inhibition ultimately leads to cell death. "Our studies showed that MGd induces oxidative stress in cancer cells," says Hacia, who is a member of USC's Institute for Genetic Medicine, "and this leads to disruption of z...

Scientists take aim at virulent bacteria by decoding machinery of key control enzyme

... processes such as regulating gene expression, DNA replication and repair. In humans DNA methylation occurs on the C (cytosine) rather than the A (adenine) nucleotide. Recently scientists have discovered a new role for Dam methylation. Dam also is essential for regulating the expression of genes responsible for...

Bioinformatics reveals new gene regulation system

...system for regulating genes essential to bacterial replication ?and they did it solely by computer keystrokes and mouse clicks. Mikhail Gelfand, a Howard Hughes Medical Institute international research scholar at the Institute for Information Transmission Problems (IITP) in Moscow, and his postdoctoral fellow, ...

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