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Tag: "replacement" at biology news

Gene therapy converts dead bone graft to new, living tissue

...s cancers or injuries whose treatment involves the replacement of large sections of bone. Cancers such as osteosarcoma, one of the most common types of bone cancers, or tumors that occur adjacent to bones, often must be treated by removing the diseased section of bone and replacing it with the only alternative a...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...r dystrophies presents a unique challenge, because replacement of deficient, therapeutic proteins invokes an immu...pe disease. The Duke team earlier developed enzyme replacement therapy, in which a normal version of the faulty enzyme in those with the disease is infused weekly....

Scientists rid stem cell culture of key animal cells

... Unexpectedly, Xu found that the presence of serum replacement promoted stem cell differentiation. Digging deeper, he found that serum replacement mimics the activity of bone morphogenetic protein (BMP), a molecule known to kick-start embryonic de...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...throughout life," they said. "Growth hormone/IGF-1 replacement in older animals reverses the age-related decline in cognitive function." The group also found that "cartilage degeneration that normally accompanies aging is accelerated by the absence of growth hormone." The researchers concluded that cancer risk...

NC State scientist finds soft tissue in T. rex bones

...ntially transformed into "rocks" through a gradual replacement of all organic material by minerals. New research by a North Carolina State University paleontologist, however, could literally turn that theory inside out. Dr. Mary Schweitzer, assistant professor of paleontology with a joint appointment at the N.C...

Tiny scaffolding allows stem cells to become working fat cells

...ile waiting for a donor organ, or even providing a replacement organ." Along with Xihai Kang and Yubing Xie, both postdoctoral fellows in his laboratory, Kniss built a fabric-like carpet of polyethylene terephathalene (PET), or Dacron, fibers that served as scaffolding upon which new fat cells were grown. In c...

PCRM develops world's first cruelty-free insulin assay

...n-vitro, or test-tube, procedure using a synthetic replacement for the fetal calf serum used as a culturing mediu..., peptide- and protein-free, media supplement as a replacement for calf serum--basically a synthetic formula with cofactors and trace elements that promote cell gr...

PGA on a tour under the skin

...er of infections in people with prosthetic joints, replacement heart valves, and intravenous catheters, and antibiotic resistance makes it tough to battle. Moreover, the mechanism through which the organism becomes so pathogenic once the protective barrier of the skin is removed remains unclear. In their study ...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...tor neurons, the Swiss researchers designed a gene replacement technology that allows the knock-down of all mutant SOD1 forms while permitting the expression of a normal type SOD1 protein that is resistant to RNA interference-based silencing. Both these effects are expressed long-term via delivery by a single le...

One gene links newborn neurons with those that die in diseases such as Alzheimer's

...n to those that are related to the choreography of replacement itself." "In addition, because we study birds that learn their songs, the story relates to a fascinating, learned behavior, so it offers the opportunity to show how integration at different levels of biology can be made to pay," Nottebohm says. "It ...

UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

...tear can generate micrometer-sized particles. "As replacement joints are becoming increasingly common in aging populations, our results explain how such devices fail and suggest that improvements should be made in artificial joint design," said the study's senior author K.L. Paul Sung, Ph.D., UCSD professor of ...

Too much water may be as dangerous as too little during long-distance athletic events

...wever, that fixed global recommendations for fluid replacement may not be optimal for individual athletes of different body types and with varying degrees of training and heat acclimatization. ...

Bush, Cheney and Rumsfeld are now species of slime-mold beetles -- but strictly in homage

...wever, that fixed global recommendations for fluid replacement may not be optimal for individual athletes of different body types and with varying degrees of training and heat acclimatization. ...

New design : complete

...wever, that fixed global recommendations for fluid replacement may not be optimal for individual athletes of different body types and with varying degrees of training and heat acclimatization. ...

Scientists use manufacturing methods to reconstruct mastodon

...development, for instance, or manually sculpting a replacement bone, based on measurements and comparisons with t...eleton. Next, technicians in the UM3D lab made the replacement bones with a rapid prototyping system that converts a digital representation back into a three-dimen...

Stem cells in bone marrow replenish mouse ovaries

...ause and could represent an alternative to hormone replacement therapy. Finally, the researchers would like to find out whether these stem cells could be coaxed to produce eggs in the laboratory, potentially providing a new source of eggs for therapeutic cloning. Johnson et al.: "Oocyte Generation in Adult Mamm...

Fungus-farming termites descend from an African rain forest Eve

...er-gatherers, or, and probably more often, through replacement of local hunter-gatherers by farmers. The agricultural lifestyle has allowed both humans and their domesticated organisms to exploit unfavourable areas more effectively and to reach far higher population densities than each of their non-agricultural ...

New method shows it is possible to grow bone for grafts within a patient's body

...ous bone disease, it may even be possible to grown replacement bone at an early stage and freeze it so it can be used when it is needed, says Prasad. Despite the fact that living bone is continually growing and reshaping, the numerous attempts to coax it to grow bone outside of the body--in vitro--have all fail...

Arthritis: What Wnt wrong?

...oint tissue from patients who underwent total knee replacement for rheumatoid arthritis (RA), osteoarthritis (OA), or non-arthritic injury. Using several molecular methods, Wakitani's group identified Wnt-7b and -10a as genes that were significantly upregulated in the arthritic knee tissues. However, protein ex...

New complete muscle grown in the lab

...ide the "seed" cells for a person's own engineered replacement muscle. For example, the lab-grown muscles could replace tissue lost to severe trauma such as burns, or build up muscle that has weakened or wasted away in diseases like AIDS. Until now, most scientists have not attempted to provide engineered tissu...

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